{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361981470547996160.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1146/annurev-biochem-062917-012405"}},{"identifier":{"@type":"URI","@value":"https://www.annualreviews.org/doi/pdf/10.1146/annurev-biochem-062917-012405"}}],"dc:title":[{"@value":"Translesion and Repair DNA Polymerases: Diverse Structure and Mechanism"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p> The number of DNA polymerases identified in each organism has mushroomed in the past two decades. Most newly found DNA polymerases specialize in translesion synthesis and DNA repair instead of replication. Although intrinsic error rates are higher for translesion and repair polymerases than for replicative polymerases, the specialized polymerases increase genome stability and reduce tumorigenesis. Reflecting the numerous types of DNA lesions and variations of broken DNA ends, translesion and repair polymerases differ in structure, mechanism, and function. Here, we review the unique and general features of polymerases specialized in lesion bypass, as well as in gap-filling and end-joining synthesis. </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381981470547996160","@type":"Researcher","foaf:name":[{"@value":"Wei Yang"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA;"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981470547996161","@type":"Researcher","foaf:name":[{"@value":"Yang Gao"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA;"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00664154"},{"@type":"EISSN","@value":"15454509"}],"prism:publicationName":[{"@value":"Annual Review of Biochemistry"}],"dc:publisher":[{"@value":"Annual Reviews"}],"prism:publicationDate":"2018-06-20","prism:volume":"87","prism:number":"1","prism:startingPage":"239","prism:endingPage":"261"},"reviewed":"false","url":[{"@id":"https://www.annualreviews.org/doi/pdf/10.1146/annurev-biochem-062917-012405"}],"createdAt":"2018-03-01","modifiedAt":"2021-10-05","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360005519217511424","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The DNA polymerases of\n                    <i>Drosophila melanogaster</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1360290617876291968","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Pold4, the fourth subunit of replicative polymerase δ, suppresses gene conversion in the immunoglobulin-variable gene in avian DT40 cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360853567778658688","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Error-prone bypass patch by a low-fidelity variant of DNA polymerase zeta in human cells"}]},{"@id":"https://cir.nii.ac.jp/crid/2051433317024392832","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The in vivo role of Rev1 in mutagenesis and carcinogenesis"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1146/annurev-biochem-062917-012405"},{"@type":"CROSSREF","@value":"10.1080/19336934.2019.1710076_references_DOI_VBnFd9DGrBdnGF9PTOefyBOdsaN"},{"@type":"CROSSREF","@value":"10.1016/j.dnarep.2021.103056_references_DOI_VBnFd9DGrBdnGF9PTOefyBOdsaN"},{"@type":"CROSSREF","@value":"10.1186/s41021-020-0148-1_references_DOI_VBnFd9DGrBdnGF9PTOefyBOdsaN"},{"@type":"CROSSREF","@value":"10.1016/j.dnarep.2021.103052_references_DOI_VBnFd9DGrBdnGF9PTOefyBOdsaN"}]}