{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361981470631361024.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1183/09031936.00186214"}},{"identifier":{"@type":"URI","@value":"https://syndication.highwire.org/content/doi/10.1183/09031936.00186214"}}],"dc:title":[{"@value":"Influenza virus-induced lung injury: pathogenesis and implications for treatment"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>The influenza viruses are some of the most important human pathogens, causing substantial seasonal and pandemic morbidity and mortality. In humans, infection of the lower respiratory tract of can result in flooding of the alveolar compartment, development of acute respiratory distress syndrome and death from respiratory failure. Influenza-mediated damage of the airway, alveolar epithelium and alveolar endothelium results from a combination of: 1) intrinsic viral pathogenicity, attributable to its tropism for host airway and alveolar epithelial cells; and 2) a robust host innate immune response, which, while contributing to viral clearance, can worsen the severity of lung injury. In this review, we summarise the molecular events at the virus–host interface during influenza virus infection, highlighting some of the important cellular responses. We discuss immune-mediated viral clearance, the mechanisms promoting or perpetuating lung injury, lung regeneration after influenza-induced injury, and recent advances in influenza prevention and therapy.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381981470631361026","@type":"Researcher","foaf:name":[{"@value":"Susanne Herold"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981470631361024","@type":"Researcher","foaf:name":[{"@value":"Christin Becker"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981470631361027","@type":"Researcher","foaf:name":[{"@value":"Karen M. Ridge"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981470631361025","@type":"Researcher","foaf:name":[{"@value":"G.R. Scott Budinger"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"09031936"},{"@type":"EISSN","@value":"13993003"}],"prism:publicationName":[{"@value":"European Respiratory Journal"}],"dc:publisher":[{"@value":"European Respiratory Society (ERS)"}],"prism:publicationDate":"2015-03-18","prism:volume":"45","prism:number":"5","prism:startingPage":"1463","prism:endingPage":"1478"},"reviewed":"false","url":[{"@id":"https://syndication.highwire.org/content/doi/10.1183/09031936.00186214"}],"createdAt":"2015-03-20","modifiedAt":"2025-02-24","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004235935049600","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Premedication with Clarithromycin Is Effective against Secondary Bacterial Pneumonia during Influenza Virus Infection in a Pulmonary Emphysema Mouse Model"}]},{"@id":"https://cir.nii.ac.jp/crid/1360009142707938432","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Immunopathogenesis of SARS-CoV-2-induced pneumonia: lessons from influenza virus infection"}]},{"@id":"https://cir.nii.ac.jp/crid/1360016862131896320","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Teleost swim bladder, an ancient air-filled organ that elicits mucosal immune responses"}]},{"@id":"https://cir.nii.ac.jp/crid/1360572092393879552","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Growth capability of epidemic influenza viruses in Japan since the 2009 H1N1 pandemic"}]},{"@id":"https://cir.nii.ac.jp/crid/1360869855126783872","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Seasonal fluctuation of serum Krebs von den Lungen‐6 levels in systemic sclerosis‐associated interstitial lung disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1361694371448614272","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Linear ubiquitin assembly complex regulates lung epithelial–driven responses during influenza infection"}]},{"@id":"https://cir.nii.ac.jp/crid/1390300910355778176","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"A Case of COVID-19-associated Pulmonary <i>Aspergillosis</i> Diagnosed after Hemoptysis"},{"@language":"ja","@value":"喀血を契機に診断されたCOVID-19関連肺アスペルギルス症の1例"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1183/09031936.00186214"},{"@type":"CROSSREF","@value":"10.1124/jpet.116.233932_references_DOI_Y37DHFkYttDyLzThhcy7FETbLza"},{"@type":"CROSSREF","@value":"10.1186/s41232-020-00148-1_references_DOI_Y37DHFkYttDyLzThhcy7FETbLza"},{"@type":"CROSSREF","@value":"10.1038/s41421-022-00393-3_references_DOI_Y37DHFkYttDyLzThhcy7FETbLza"},{"@type":"CROSSREF","@value":"10.11150/kansenshogakuzasshi.e23030_references_DOI_Y37DHFkYttDyLzThhcy7FETbLza"},{"@type":"CROSSREF","@value":"10.1007/s00705-021-04976-5_references_DOI_Y37DHFkYttDyLzThhcy7FETbLza"},{"@type":"CROSSREF","@value":"10.1111/1756-185x.15254_references_DOI_Y37DHFkYttDyLzThhcy7FETbLza"},{"@type":"CROSSREF","@value":"10.1172/jci128368_references_DOI_Y37DHFkYttDyLzThhcy7FETbLza"}]}