{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361981471065327104.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1186/1471-2105-9-392"}},{"identifier":{"@type":"URI","@value":"https://link.springer.com/content/pdf/10.1186/1471-2105-9-392.pdf"}}],"dc:title":[{"@value":"PredGPI: a GPI-anchor predictor"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title>\n          <jats:sec>\n            <jats:title>Background</jats:title>\n            <jats:p>Several eukaryotic proteins associated to the extracellular leaflet of the plasma membrane carry a Glycosylphosphatidylinositol (GPI) anchor, which is linked to the C-terminal residue after a proteolytic cleavage occurring at the so called ω-site. Computational methods were developed to discriminate proteins that undergo this post-translational modification starting from their aminoacidic sequences. However more accurate methods are needed for a reliable annotation of whole proteomes.</jats:p>\n          </jats:sec>\n          <jats:sec>\n            <jats:title>Results</jats:title>\n            <jats:p>Here we present PredGPI, a prediction method that, by coupling a Hidden Markov Model (HMM) and a Support Vector Machine (SVM), is able to efficiently predict both the presence of the GPI-anchor and the position of the ω-site. PredGPI is trained on a non-redundant dataset of experimentally characterized GPI-anchored proteins whose annotation was carefully checked in the literature.</jats:p>\n          </jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion</jats:title>\n            <jats:p>PredGPI outperforms all the other previously described methods and is able to correctly replicate the results of previously published high-throughput experiments. PredGPI reaches a lower rate of false positive predictions with respect to other available methods and it is therefore a costless, rapid and accurate method for screening whole proteomes.</jats:p>\n          </jats:sec>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381981471065327105","@type":"Researcher","foaf:name":[{"@value":"Andrea Pierleoni"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981471065327104","@type":"Researcher","foaf:name":[{"@value":"Rita Casadio"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981471065327106","@type":"Researcher","foaf:name":[{"@value":"Pier Luigi Martelli"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"14712105"},{"@type":"PISSN","@value":"https://id.crossref.org/issn/14712105"}],"prism:publicationName":[{"@value":"BMC Bioinformatics"}],"dc:publisher":[{"@value":"Springer Science and Business Media LLC"}],"prism:publicationDate":"2008-09-23","prism:volume":"9","prism:number":"1","prism:startingPage":"392"},"reviewed":"false","url":[{"@id":"https://link.springer.com/content/pdf/10.1186/1471-2105-9-392.pdf"}],"createdAt":"2008-09-23","modifiedAt":"2021-09-01","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050001338815139968","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"CD109: a multifunctional GPI‐anchored protein with key roles in tumor progression and physiological homeostasis"},{"@value":"CD109: a multifunctional GPI-anchored protein with key roles in tumor progression and physiological homeostasis"}]},{"@id":"https://cir.nii.ac.jp/crid/1050850247205875072","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Novel Babesia bovis exported proteins that modify properties of infected red blood 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article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Complex transcriptional regulation and independent evolution of fungal-like traits in a relative of animals"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004234495788032","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"GPI-anchor synthesis is indispensable for the germline development of the nematode<i>Caenorhabditis elegans</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004236938824192","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Food Intake Affects Sperm-Egg Fusion Through the GIP/PSG17 Axis in Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360022305562048384","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Naturally acquired antibody kinetics against\n                  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