Adaptive Molecular Evolution for 13,000 Phage Generations

DOI PDF 被引用文献3件
  • Holly A Wichman
    Department of Biological Sciences and Initiative for Bioinformatics and Evolutionary Studies, University of Idaho, Moscow, Idaho 83844-3051
  • Jack Millstein
    Department of Biological Sciences and Initiative for Bioinformatics and Evolutionary Studies, University of Idaho, Moscow, Idaho 83844-3051
  • J J Bull
    Department of Integrative Biology and Institute of Cellular and Molecular Biology, University of Texas, Austin, Texas 78712-1023

説明

<jats:title>Abstract</jats:title> <jats:p>Bacteriophage φX174 was evolved on a continuous supply of sensitive hosts for 180 days (∼13,000 phage generations). The average rate of nucleotide substitution was nearly 0.2% (11 substitutions)/20 days, and, surprisingly, substitutions accumulated in a clock-like manner throughout the study, except for a low rate during the first 20 days. Rates of silent and missense substitutions varied over time and among genes. Approximately 40% of the 71 missense changes and 25% of the 58 silent changes have been observed in previous adaptations; the rate of parallel substitution was highest in the early phase of the evolution, but 7% of the later changes had evolved in previous studies of much shorter duration. Several lines of evidence suggest that most of the changes were adaptive, even many of the silent substitutions. The sustained, high rate of adaptive evolution for 180 days defies a model of adaptation to a constant environment. We instead suggest that continuing molecular evolution reflects a potentially indefinite arms race, stemming from high levels of co-infection and the resulting conflict among genomes competing within the same cell.</jats:p>

収録刊行物

  • Genetics

    Genetics 170 (1), 19-31, 2005-05-01

    Oxford University Press (OUP)

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