{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361981471179791104.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1038/sj.leu.2402665"}},{"identifier":{"@type":"URI","@value":"https://www.nature.com/articles/2402665.pdf"}},{"identifier":{"@type":"URI","@value":"https://www.nature.com/articles/2402665"}},{"identifier":{"@type":"PMID","@value":"12399976"}}],"dc:title":[{"@value":"A novel infant acute lymphoblastic leukemia cell line with MLL-AF5q31 fusion transcript"}],"description":[{"notation":[{"@value":"Infant acute lymphoblastic leukemia (ALL) is characterized by the presence of the proB phenotype (CD10(-)/CD19(+)), poor prognosis and frequent rearrangement of the mixed lineage leukemia (MLL) gene. The most frequent rearrangement is t(4;11)(q21;q23), the role of whose product, the MLL-AF4 fusion transcript, has been extensively studied in leukemogenesis. In a cell line of infant leukemia with MLL rearrangement denoted KP-L-RY, panhandle PCR amplification of cDNA revealed the presence of a fusion transcript, MLL-AF5q31, indicating that AF5q31 is also a partner gene of MLL. In this fusion transcript the MLL exon 6 is fused in frame to the 5' side of the putative transactivation domain of AF5q31. The AF5q31 protein is a member of the AF4/LAF4/FMR2-related family of proteins, which have been suggested to play a role in hematopoietic cell growth and differentiation. The MLL-AF5q31 fusion transcript, although probably rare, appears to be associated with the pathogenesis of infant ALL like MLL-AF4. Co-expression of HoxA9 and Meis1 genes in the KP-L-RY cell line indicated possible functional similarity between MLL-AF4 and MLL-AF5q31. Further understanding of the function of AF5q31 as well as the specific leukemogenic mechanism of MLL-AF5q31 awaits future studies."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381981471179791114","@type":"Researcher","foaf:name":[{"@value":"T Imamura"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981471179791107","@type":"Researcher","foaf:name":[{"@value":"A Morimoto"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981471179791113","@type":"Researcher","foaf:name":[{"@value":"S Ikushima"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981471179791105","@type":"Researcher","foaf:name":[{"@value":"N Kakazu"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981471179791111","@type":"Researcher","foaf:name":[{"@value":"S Hada"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981471179791104","@type":"Researcher","foaf:name":[{"@value":"Y Tabata"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981471179791108","@type":"Researcher","foaf:name":[{"@value":"T Yagi"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981471179791109","@type":"Researcher","foaf:name":[{"@value":"T Inaba"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981471179791110","@type":"Researcher","foaf:name":[{"@value":"S Hibi"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981471179791106","@type":"Researcher","foaf:name":[{"@value":"T Sugimoto"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981471179791112","@type":"Researcher","foaf:name":[{"@value":"S Imashuku"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"08876924"},{"@type":"EISSN","@value":"14765551"}],"prism:publicationName":[{"@value":"Leukemia"}],"dc:publisher":[{"@value":"Springer Science and Business Media LLC"}],"prism:publicationDate":"2002-10-28","prism:volume":"16","prism:number":"11","prism:startingPage":"2302","prism:endingPage":"2308"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://www.springer.com/tdm","https://www.springer.com/tdm"],"url":[{"@id":"https://www.nature.com/articles/2402665.pdf"},{"@id":"https://www.nature.com/articles/2402665"}],"createdAt":"2002-11-07","modifiedAt":"2023-04-25","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Oncogene%20Proteins,%20Fusion","dc:title":"Oncogene Proteins, Fusion"},{"@id":"https://cir.nii.ac.jp/all?q=Polymerase%20Chain%20Reaction","dc:title":"Polymerase Chain Reaction"},{"@id":"https://cir.nii.ac.jp/all?q=Translocation,%20Genetic","dc:title":"Translocation, Genetic"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Line","dc:title":"Cell Line"},{"@id":"https://cir.nii.ac.jp/all?q=Biomarkers,%20Tumor","dc:title":"Biomarkers, Tumor"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Myeloid%20Ecotropic%20Viral%20Integration%20Site%201%20Protein","dc:title":"Myeloid Ecotropic Viral Integration Site 1 Protein"},{"@id":"https://cir.nii.ac.jp/all?q=In%20Situ%20Hybridization,%20Fluorescence","dc:title":"In Situ Hybridization, Fluorescence"},{"@id":"https://cir.nii.ac.jp/all?q=DNA%20Primers","dc:title":"DNA Primers"},{"@id":"https://cir.nii.ac.jp/all?q=Homeodomain%20Proteins","dc:title":"Homeodomain Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Chromosomes,%20Human,%20Pair%2011","dc:title":"Chromosomes, Human, Pair 11"},{"@id":"https://cir.nii.ac.jp/all?q=Chromosome%20Mapping","dc:title":"Chromosome Mapping"},{"@id":"https://cir.nii.ac.jp/all?q=Infant","dc:title":"Infant"},{"@id":"https://cir.nii.ac.jp/all?q=DNA,%20Neoplasm","dc:title":"DNA, Neoplasm"},{"@id":"https://cir.nii.ac.jp/all?q=Exons","dc:title":"Exons"},{"@id":"https://cir.nii.ac.jp/all?q=Precursor%20Cell%20Lymphoblastic%20Leukemia-Lymphoma","dc:title":"Precursor Cell Lymphoblastic Leukemia-Lymphoma"},{"@id":"https://cir.nii.ac.jp/all?q=Artificial%20Gene%20Fusion","dc:title":"Artificial Gene Fusion"},{"@id":"https://cir.nii.ac.jp/all?q=Neoplasm%20Proteins","dc:title":"Neoplasm Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Blotting,%20Southern","dc:title":"Blotting, Southern"},{"@id":"https://cir.nii.ac.jp/all?q=Acute%20Disease","dc:title":"Acute Disease"},{"@id":"https://cir.nii.ac.jp/all?q=Chromosomes,%20Human,%20Pair%204","dc:title":"Chromosomes, Human, Pair 4"},{"@id":"https://cir.nii.ac.jp/all?q=Myeloid-Lymphoid%20Leukemia%20Protein","dc:title":"Myeloid-Lymphoid Leukemia Protein"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004232000606976","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"All-trans retinoic acid combined with 5-Aza-2′-deoxycitidine induces C/EBPα expression and growth inhibition in MLL-AF9-positive leukemic cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360017282437074944","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Characterization of <i>KMT2A::MATR3</i> fusion in a patient with acute lymphoblastic leukemia and monitoring of minimal residual disease by nanoplate digital PCR"}]},{"@id":"https://cir.nii.ac.jp/crid/1360294643740601984","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The CDK4/6-UCHL5-BRD4 axis confers resistance to BET inhibitors in MLL-rearranged leukemia cells by suppressing BRD4 protein degradation"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1038/sj.leu.2402665"},{"@type":"OPENAIRE","@value":"doi_dedup___::7b6accc0ed3fa6f1e4328126ddcdea3e"},{"@type":"CROSSREF","@value":"10.1002/pbc.30120_references_DOI_aCT8yROMWPiKZJJIvgeICWjMX7S"},{"@type":"CROSSREF","@value":"10.1016/j.bbrc.2021.12.063_references_DOI_aCT8yROMWPiKZJJIvgeICWjMX7S"},{"@type":"CROSSREF","@value":"10.1016/j.bbrc.2012.09.131_references_DOI_aCT8yROMWPiKZJJIvgeICWjMX7S"}]}