{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361981471185822720.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1146/annurev.biochem.73.011303.073823"}},{"identifier":{"@type":"URI","@value":"https://www.annualreviews.org/doi/pdf/10.1146/annurev.biochem.73.011303.073823"}},{"identifier":{"@type":"NAID","@value":"30022175539"}}],"dc:title":[{"@value":"Intermediate Filaments: Molecular Structure, Assembly Mechanism, and Integration Into Functionally Distinct Intracellular Scaffolds"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>▪ Abstract  The superfamily of intermediate filament (IF) proteins contains at least 65 distinct proteins in man, which all assemble into ∼10 nm wide filaments and are principal structural elements both in the nucleus and the cytoplasm with essential scaffolding functions in metazoan cells. At present, we have only circumstantial evidence of how the highly divergent primary sequences of IF proteins lead to the formation of seemingly similar polymers and how this correlates with their function in individual cells and tissues. Point mutations in IF proteins, particularly in lamins, have been demonstrated to lead to severe, inheritable multi-systemic diseases, thus underlining their importance at several functional levels. Recent structural work has now begun to shed some light onto the complex fine tuning of structure and function in these fibrous, coiled coil forming multidomain proteins and their contribution to cellular physiology and gene regulation.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381981471185822721","@type":"Researcher","foaf:name":[{"@value":"Harald Herrmann"}],"jpcoar:affiliationName":[{"@value":"Department of Cell Biology, German Cancer Research Center, D-69120 Heidelberg, Germany;"},{"@value":"Maurice E. Müller Institute for Structural Biology, Biozentrum, CH-4056 Basel, Switzerland;"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981471185822720","@type":"Researcher","foaf:name":[{"@value":"Ueli Aebi"}],"jpcoar:affiliationName":[{"@value":"Department of Cell Biology, German Cancer Research Center, D-69120 Heidelberg, Germany;"},{"@value":"Maurice E. Müller Institute for Structural Biology, Biozentrum, CH-4056 Basel, Switzerland;"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00664154"},{"@type":"EISSN","@value":"15454509"},{"@type":"PISSN","@value":"http://id.crossref.org/issn/00664154"}],"prism:publicationName":[{"@value":"Annual Review of Biochemistry"}],"dc:publisher":[{"@value":"Annual Reviews"}],"prism:publicationDate":"2004-06","prism:volume":"73","prism:number":"1","prism:startingPage":"749","prism:endingPage":"789"},"reviewed":"false","url":[{"@id":"https://www.annualreviews.org/doi/pdf/10.1146/annurev.biochem.73.011303.073823"}],"createdAt":"2004-06-09","modifiedAt":"2023-04-28","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004230142384384","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"New insights into roles of intermediate filament phosphorylation and progeria 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