{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361981471221543552.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1038/42506"}},{"identifier":{"@type":"URI","@value":"http://www.nature.com/articles/42506.pdf"}},{"identifier":{"@type":"URI","@value":"http://www.nature.com/articles/42506"}},{"identifier":{"@type":"URI","@value":"http://www.nature.com/doifinder/10.1038/42506"}},{"identifier":{"@type":"PMID","@value":"9177352"}},{"identifier":{"@type":"NAID","@value":"80009665407"}}],"dc:title":[{"@value":"A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis"}],"description":[{"notation":[{"@value":"Leukotriene B4 (LTB4) is a potent chemoattractant that is primarily involved in inflammation, immune responses and host defence against infection. LTB4 activates inflammatory cells by binding to its cell-surface receptor (BLTR). LTB4 can also bind and activate the intranudear transcription factor PPAR alpha, resulting in the activation of genes that terminate inflammatory processes. Here we report the cloning of the complementary DNA encoding a cell-surface LTB4 receptor that is highly expressed in human leukocytes. Using a subtraction strategy, we isolated two cDNA clones (HL-1 and HL-5) from retinoic acid-differentiated HL-60 cells. These two clones contain identical open reading frames encoding a protein of 352 amino acids and predicted to contain seven membrane-spanning domains, but different 5'-untranslated regions. Membrane fractions of Cos-7 cells transfected with an expression construct containing the open reading frame of HL-5 showed specific LTB4 binding, with a K(d) (0.154nM) comparable to that observed in retinoic acid-differentiated HL-60 cells. In CHO cells stably expressing this receptor, LTB4 induced increases in intracellular calcium, D-myo-inositol-1,4,5-triphosphate (InsP3) accumulation, and inhibition of adenylyl cyclase. Furthermore, CHO cells expressing exogenous BLTR showed marked chemotactic responses towards low concentrations of LTB4 in a pertussis-toxin-sensitive manner. Our findings, together with previous reports, show that LTB4 is a unique lipid mediator that interacts with both cell-surface and nuclear receptors."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381981471221543556","@type":"Researcher","foaf:name":[{"@value":"Takehiko Yokomizo"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981471221543553","@type":"Researcher","foaf:name":[{"@value":"Takashi Izumi"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981471221543552","@type":"Researcher","foaf:name":[{"@value":"Kyungho Chang"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981471221543554","@type":"Researcher","foaf:name":[{"@value":"Yoh Takuwa"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981471221543555","@type":"Researcher","foaf:name":[{"@value":"Takao Shimizu"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00280836"},{"@type":"EISSN","@value":"14764687"},{"@type":"PISSN","@value":"https://id.crossref.org/issn/00280836"}],"prism:publicationName":[{"@value":"Nature"}],"dc:publisher":[{"@value":"Springer Science and Business Media LLC"}],"prism:publicationDate":"1997-06","prism:volume":"387","prism:number":"6633","prism:startingPage":"620","prism:endingPage":"624"},"reviewed":"false","dc:rights":["http://www.springer.com/tdm"],"url":[{"@id":"http://www.nature.com/articles/42506.pdf"},{"@id":"http://www.nature.com/articles/42506"},{"@id":"http://www.nature.com/doifinder/10.1038/42506"}],"createdAt":"2002-07-26","modifiedAt":"2023-05-18","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=DNA,%20Complementary","dc:title":"DNA, Complementary"},{"@id":"https://cir.nii.ac.jp/all?q=Sequence%20Homology,%20Amino%20Acid","dc:title":"Sequence Homology, Amino Acid"},{"@id":"https://cir.nii.ac.jp/all?q=Chemotaxis","dc:title":"Chemotaxis"},{"@id":"https://cir.nii.ac.jp/all?q=Molecular%20Sequence%20Data","dc:title":"Molecular Sequence Data"},{"@id":"https://cir.nii.ac.jp/all?q=Receptors,%20Leukotriene%20B4","dc:title":"Receptors, Leukotriene B4"},{"@id":"https://cir.nii.ac.jp/all?q=HL-60%20Cells","dc:title":"HL-60 Cells"},{"@id":"https://cir.nii.ac.jp/all?q=Tretinoin","dc:title":"Tretinoin"},{"@id":"https://cir.nii.ac.jp/all?q=Leukotriene%20B4","dc:title":"Leukotriene B4"},{"@id":"https://cir.nii.ac.jp/all?q=GTP-Binding%20Proteins","dc:title":"GTP-Binding Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=COS%20Cells","dc:title":"COS Cells"},{"@id":"https://cir.nii.ac.jp/all?q=Leukocytes","dc:title":"Leukocytes"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Cloning,%20Molecular","dc:title":"Cloning, Molecular"},{"@id":"https://cir.nii.ac.jp/all?q=Cells,%20Cultured","dc:title":"Cells, Cultured"},{"@id":"https://cir.nii.ac.jp/all?q=Signal%20Transduction","dc:title":"Signal Transduction"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050001335791556224","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"In vivo imaging reveals PKA regulation of ERK activity during neutrophil recruitment to inflamed intestines."}]},{"@id":"https://cir.nii.ac.jp/crid/1050871070867478912","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Expression of leukotriene B_4 receptor 1 defines functionally distinct DCs that control allergic skin inflammation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360002216123231360","@type":"Article","resourceType":"学術雑誌論文(journal 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Injury"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004237628529152","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Role of the high-affinity leukotriene B4 receptor signaling in fibrosis after unilateral ureteral obstruction in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360005519731687552","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Leukotriene B\n                    <sub>4</sub>\n                    receptor 1 exacerbates inflammation following myocardial infarction"}]},{"@id":"https://cir.nii.ac.jp/crid/1360009142687054976","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Eicosanoids in Skin Wound Healing"}]},{"@id":"https://cir.nii.ac.jp/crid/1360009142730800256","@type":"Article","resourceType":"学術雑誌論文(journal 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glomerulonephritis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360022304970942080","@type":"Article","resourceType":"preprint","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Role of the high-affinity leukotriene B\n                  <sub>4</sub>\n                  receptor signaling in fibrosis after unilateral ureteral obstruction in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360025429428244096","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Traveling-wave chemotaxis of neutrophil-like HL-60 cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283691612240640","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Leukotriene Receptors"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283691835617408","@type":"Article","resourceType":"学術雑誌論文(journal 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healing by accelerating keratinocyte migration via the BLT2 receptor"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565167634237184","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"AML1 enhances the expression of leukotriene B\n                    <sub>4</sub>\n                    type‐1 receptor in leukocytes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565168592561280","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Lipid Mediators in Health and Disease: Enzymes and Receptors as Therapeutic Targets for the Regulation of Immunity and Inflammation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567181888764032","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"A high-affinity monoclonal antibody against the FLAG tag useful for G-protein-coupled receptor 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leukotriene B<sub>4</sub> receptor <scp>BLT</scp>2 protects barrier function via actin polymerization with phosphorylation of myosin phosphatase target subunit 1 in human keratinocytes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567186742525056","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Critical role of leukotriene B4 receptor signaling in mouse 3T3-L1 preadipocyte differentiation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567186747393408","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Expression of Leukotriene Receptors in the Rat Dorsal Root Ganglion and the Effects on Pain Behaviors"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567186787917824","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Leukotriene Enhances NMDA-Induced Inward Currents in 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