{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361981471240929280.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.bmc.2009.01.064"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0968089609001102?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0968089609001102?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"19223184"}}],"dc:title":[{"@value":"Penicilliols A and B, novel inhibitors specific to mammalian Y-family DNA polymerases"}],"description":[{"notation":[{"@value":"Penicilliols A (1) and B (2) are novel 5-methoxy-3(2H)-furanones isolated from cultures of a fungus (Penicillium daleae K.M. Zalessky) derived from a sea moss, and their structures were determined by spectroscopic analyses. These compounds selectively inhibited activities of eukaryotic Y-family DNA polymerases (pols) (i.e., pols eta, iota and kappa), and compound 1 was a stronger inhibitor than compound 2. Among mammalian Y-family pols, mouse pol iota activity was most strongly inhibited by compounds 1 and 2, with IC(50) values of 19.8 and 32.5 microM, respectively. On the other hand, activities of many other pols, such as A-family (i.e., pol gamma), B-family (i.e., pols alpha, delta and epsilon) or X-family (i.e., pols beta, lambda and terminal deoxynucleotidyl transferase), and some DNA metabolic enzymes, such as calf primase of pol alpha, human immunodeficiency virus type-1 (HIV-1) reverse transcriptase, human telomerase, T7 RNA polymerase, mouse IMP dehydrogenase (type II), human topoisomerases I and II, T4 polynucleotide kinase or bovine deoxyribonuclease I, are not influenced by these compounds. In conclusion, this is the first report on potent inhibitors of mammalian Y-family pols."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381981471240929281","@type":"Researcher","foaf:name":[{"@value":"Takuma Kimura"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981471240929282","@type":"Researcher","foaf:name":[{"@value":"Toshifumi Takeuchi"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981471240929153","@type":"Researcher","foaf:name":[{"@value":"Yuko Kumamoto-Yonezawa"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981471240929285","@type":"Researcher","foaf:name":[{"@value":"Eiji Ohashi"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981471240929283","@type":"Researcher","foaf:name":[{"@value":"Haruo Ohmori"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981471240929154","@type":"Researcher","foaf:name":[{"@value":"Chikahide Masutani"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981471240929286","@type":"Researcher","foaf:name":[{"@value":"Fumio Hanaoka"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981471240929152","@type":"Researcher","foaf:name":[{"@value":"Fumio Sugawara"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981471240929280","@type":"Researcher","foaf:name":[{"@value":"Hiromi Yoshida"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981471240929284","@type":"Researcher","foaf:name":[{"@value":"Yoshiyuki Mizushina"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"09680896"}],"prism:publicationName":[{"@value":"Bioorganic & Medicinal Chemistry"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2009-03","prism:volume":"17","prism:number":"5","prism:startingPage":"1811","prism:endingPage":"1816"},"reviewed":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","https://www.elsevier.com/legal/tdmrep-license"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S0968089609001102?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S0968089609001102?httpAccept=text/plain"}],"createdAt":"2009-02-02","modifiedAt":"2025-10-18","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Penicillium","dc:title":"Penicillium"},{"@id":"https://cir.nii.ac.jp/all?q=DNA-Directed%20DNA%20Polymerase","dc:title":"DNA-Directed DNA Polymerase"},{"@id":"https://cir.nii.ac.jp/all?q=Inhibitory%20Concentration%2050","dc:title":"Inhibitory Concentration 50"},{"@id":"https://cir.nii.ac.jp/all?q=Kinetics","dc:title":"Kinetics"},{"@id":"https://cir.nii.ac.jp/all?q=Lactones","dc:title":"Lactones"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Cattle","dc:title":"Cattle"},{"@id":"https://cir.nii.ac.jp/all?q=Enzyme%20Inhibitors","dc:title":"Enzyme Inhibitors"},{"@id":"https://cir.nii.ac.jp/all?q=Nucleic%20Acid%20Synthesis%20Inhibitors","dc:title":"Nucleic Acid Synthesis Inhibitors"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004229919760640","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Carbonylation of Propargyl Carbamates with Palladium(II) Bisoxazoline Catalysts: Efficient Synthesis of 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