{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361981471243374208.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.molimm.2004.09.011"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0161589004003451?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0161589004003451?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"15607821"}}],"dc:title":[{"@value":"c-fos Overexpression in splenic B cells augments development of marginal zone B cells"}],"description":[{"notation":[{"@value":"Marginal zone (MZ)-B cells participate in very early immune responses and play a pivotal role in the first-line of defense against blood-borne Ags including bacterial LPS. Since splenic B cells from c-fos transgenic (H2-c-fos) mice are hyper-sensitive to LPS stimulation, we examined LPS-sensitivity of MZ-B cells in the spleen of H2-c-fos mice. Here, we show that proliferation of MZ-B cells from H2-c-fos mice stimulated with LPS was larger than that from control mice. Proliferation and IgM production of the H2-c-fos MZ-B cells were also larger than those of splenic follicular (FO)-B cells from the H2-c-fos mice, suggesting that c-fos overexpression augments LPS-sensitivity of MZ-B cells more than that of FO-B cells. Furthermore, the number of MZ-B cells but not that of FO-B cells in the spleen of H2-c-fos mice was two- to three-fold larger than that in control littermates. The number of transitional type II (T2)-B cells in H2-c-fos mice was also larger than that of control littermates. However, the number of transitional type I (T1)-B cells in the spleen of H2-c-fos mice was not larger than that of control mice. Moreover, this c-fos effect on differentiation of MZ-B cells was intrinsic in B cells by the competitive repopulation assay with hematopoietic stem cells of H2-c-fos and control mice. These results suggest that c-fos overexpression in B cells augments differentiation and accumulation of MZ-B cells."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380298343658425344","@type":"Researcher","foaf:name":[{"@value":"Kimihiro Yamashita"}]},{"@id":"https://cir.nii.ac.jp/crid/1380298343658425346","@type":"Researcher","foaf:name":[{"@value":"Akemi Sakamoto"}]},{"@id":"https://cir.nii.ac.jp/crid/1380298343658425473","@type":"Researcher","foaf:name":[{"@value":"Yusuke Ohkubo"}]},{"@id":"https://cir.nii.ac.jp/crid/1380298343658425347","@type":"Researcher","foaf:name":[{"@value":"Masafumi Arima"}]},{"@id":"https://cir.nii.ac.jp/crid/1380298343658425472","@type":"Researcher","foaf:name":[{"@value":"Masahiko Hatano"}]},{"@id":"https://cir.nii.ac.jp/crid/1380298343658425348","@type":"Researcher","foaf:name":[{"@value":"Yoshikazu Kuroda"}]},{"@id":"https://cir.nii.ac.jp/crid/1380298343658425345","@type":"Researcher","foaf:name":[{"@value":"Takeshi Tokuhisa"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"01615890"}],"prism:publicationName":[{"@value":"Molecular Immunology"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2005-03","prism:volume":"42","prism:number":"5","prism:startingPage":"617","prism:endingPage":"625"},"reviewed":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","https://www.elsevier.com/legal/tdmrep-license"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S0161589004003451?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S0161589004003451?httpAccept=text/plain"}],"createdAt":"2004-11-12","modifiedAt":"2025-09-27","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Lipopolysaccharides","dc:title":"Lipopolysaccharides"},{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Knockout","dc:title":"Mice, Knockout"},{"@id":"https://cir.nii.ac.jp/all?q=B-Lymphocytes","dc:title":"B-Lymphocytes"},{"@id":"https://cir.nii.ac.jp/all?q=DNA,%20Complementary","dc:title":"DNA, Complementary"},{"@id":"https://cir.nii.ac.jp/all?q=Base%20Sequence","dc:title":"Base Sequence"},{"@id":"https://cir.nii.ac.jp/all?q=Genes,%20fos","dc:title":"Genes, fos"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Differentiation","dc:title":"Cell Differentiation"},{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Transgenic","dc:title":"Mice, Transgenic"},{"@id":"https://cir.nii.ac.jp/all?q=In%20Vitro%20Techniques","dc:title":"In Vitro Techniques"},{"@id":"https://cir.nii.ac.jp/all?q=DNA-Binding%20Proteins","dc:title":"DNA-Binding Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Inbred%20C57BL","dc:title":"Mice, Inbred C57BL"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Spleen","dc:title":"Spleen"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Proliferation","dc:title":"Cell Proliferation"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360848656930552832","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Notch2 regulates the development of marginal zone B cells through Fos"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1016/j.molimm.2004.09.011"},{"@type":"OPENAIRE","@value":"doi_dedup___::008b9facdcdbfa43f9c206c1dd985a77"},{"@type":"CROSSREF","@value":"10.1016/j.bbrc.2012.01.082_references_DOI_WNC9sVslZLXWoSoPYyedy2ejGWV"}]}