{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361981471300580992.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1177/153537020122600603"}},{"identifier":{"@type":"URI","@value":"http://journals.sagepub.com/doi/pdf/10.1177/153537020122600603"}}],"dc:title":[{"@value":"Mesenchymal Stem Cells"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Within the bone marrow stroma there exists a subset of nonhematopoietic cells referred to as mesenchymal stem or mesenchymal progenitor cells. These cells can be ex vivo expanded and induced, either in vitro or in vivo, to terminally differentiate into osteoblasts, chondrocytes, adipocytes, tenocytes, myotubes, neural cells, and hematopoietic-supporting stroma. The multipotential of these cells, their easy isolation and culture, as well as their high ex vivo expansive potential make these cells an attractive therapeutic tool. In this work we will review the information dealing with the biology of mesenchymal progenitors as it has been revealed mainly by ex vivo studies performed with bone marrow-derived cells. The discussed topics include, among others, characteristics of mesenchymal progenitors, evidence for the existence of a vast repertoire of uncommitted and committed progenitors both in the bone marrow and in mesenchymal tissues, a diagram for their proliferative hierarchy, and comments on mobilization, microenvironment, and clinical use of mesenchymal progenitors. Despite the enormous data available at molecular and cellular levels, it is evident that a number of fundamental questions still need to be resolved before mesenchymal progenitors can be used for safe and effective clinical applications in the context of both cell and gene therapies.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381981471300580864","@type":"Researcher","foaf:name":[{"@value":"José J. Minguell"}],"jpcoar:affiliationName":[{"@value":"Unidad de Biología Celular, INTA, Universidad de Chile, Santiago, Chile"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981471300580992","@type":"Researcher","foaf:name":[{"@value":"Alejandro Erices"}],"jpcoar:affiliationName":[{"@value":"Unidad de Biología Celular, INTA, Universidad de Chile, Santiago, Chile"},{"@value":"Laboratorio de Trasplante de Médula Osea, Clínica Las Condes, Santiago, Chile"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981471300580865","@type":"Researcher","foaf:name":[{"@value":"Paulette Conget"}],"jpcoar:affiliationName":[{"@value":"Unidad de Biología Celular, INTA, Universidad de Chile, Santiago, Chile"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"15353702"},{"@type":"EISSN","@value":"15353699"}],"prism:publicationName":[{"@value":"Experimental Biology and Medicine"}],"dc:publisher":[{"@value":"Frontiers Media SA"}],"prism:publicationDate":"2001-06","prism:volume":"226","prism:number":"6","prism:startingPage":"507","prism:endingPage":"520"},"reviewed":"false","dc:rights":["http://journals.sagepub.com/page/policies/text-and-data-mining-license"],"url":[{"@id":"http://journals.sagepub.com/doi/pdf/10.1177/153537020122600603"}],"createdAt":"2017-07-20","modifiedAt":"2025-04-07","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360002215826766720","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The effect of decellularized bone/bone marrow produced by high-hydrostatic pressurization on the osteogenic differentiation of mesenchymal stem cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565169361420928","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Characterization of Spontaneous Bone Marrow Recovery after Sublethal Total Body Irradiation: Importance of the Osteoblastic/Adipocytic Balance"}]},{"@id":"https://cir.nii.ac.jp/crid/1360580232151791232","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Knee meniscus regeneration using autogenous injection of uncultured adipose tissue-derived regenerative cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846643127956224","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"New insights into osteoporosis: the bone–fat connection"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848657214010240","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The Potential of Muse Cells for Regenerative Medicine of Skin: Procedures to Reconstitute Skin with Muse Cell-Derived Keratinocytes, Fibroblasts, and Melanocytes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848664553997696","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Bone Marrow-Derived Conventional, But Not Cloned, Mesenchymal Stem Cells Suppress Lymphocyte Proliferation and Prevent Graft-Versus-Host Disease in Rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205103675392","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Adipose Tissue or Bone Marrow, Store for Purchasing Mesenchymal Stem Cells?"},{"@language":"ja","@value":"Gene and protein expression analysis of mesenchymal stem cells derived from rat adipose tissue and bone marrow"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001206427898368","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Spontaneous Differentiation of Adult Rat Marrow Stromal Cells in a Long-Term Culture"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680189286400","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Expression of Platelet-Derived Growth Factor Receptor Beta in Dog Mandible by Beta-Tricalcium Phosphate"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1177/153537020122600603"},{"@type":"CROSSREF","@value":"10.1292/jvms.69.95_references_DOI_Fneru7iNddO93w63t9DjUc5hi4"},{"@type":"CROSSREF","@value":"10.5466/ijoms.9.190_references_DOI_Fneru7iNddO93w63t9DjUc5hi4"},{"@type":"CROSSREF","@value":"10.1371/journal.pone.0030818_references_DOI_Fneru7iNddO93w63t9DjUc5hi4"},{"@type":"CROSSREF","@value":"10.1016/j.jid.2017.06.021_references_DOI_Fneru7iNddO93w63t9DjUc5hi4"},{"@type":"CROSSREF","@value":"10.1016/j.reth.2022.09.003_references_DOI_Fneru7iNddO93w63t9DjUc5hi4"},{"@type":"CROSSREF","@value":"10.1111/j.1365-2796.2012.02564.x_references_DOI_Fneru7iNddO93w63t9DjUc5hi4"},{"@type":"CROSSREF","@value":"10.1253/circj.cj-11-0246_references_DOI_Fneru7iNddO93w63t9DjUc5hi4"},{"@type":"CROSSREF","@value":"10.3727/096368911x605510_references_DOI_Fneru7iNddO93w63t9DjUc5hi4"},{"@type":"CROSSREF","@value":"10.1016/j.biomaterials.2011.06.008_references_DOI_Fneru7iNddO93w63t9DjUc5hi4"}]}