{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361981471408909952.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1006/abbi.2000.2123"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0003986100921234?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0003986100921234?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"11368329"}}],"dc:title":[{"@value":"Efficiency of Absorption and Metabolic Conversion of Quercetin and Its Glucosides in Human Intestinal Cell Line Caco-2"}],"description":[{"notation":[{"@value":"The efficiency of intestinal absorption and metabolic conversion of quercetin aglycone and its glucosides, quercetin-4'-O-beta-D-glucoside (Q4'G), quercetin-3-O-beta-D-glucoside (Q3G), and quercetin-3,4'-di-O-beta-D-glucoside (Q3,4'G), was estimated by using Caco-2 cell monolayers as an intestinal epithelial cell model. Aglycone was significantly lost from the apical side, resulting in the appearance of free and conjugated forms of quercetin and those of isorhamnetin in the cellular extracts. In the basolateral solution, the conjugated form of quercetin was predominant and increased with the elapse of incubation. As compared with quercetin aglycone, none of the quercetin glucosides were absorbed efficiently from apical side. However, Q4'G yielded conjugated quercetin and isorhamnetin in basolateral solution at higher amounts than Q3G or Q3,4'G. Lipophilicity of Q4'G was found to be higher than that of Q3G or Q3,4'G. This suggests that lipophilicity contributes to the relatively efficient absorption of Q4'G. It is likely that the occurrence of hydrolysis enhances the efficiency of intestinal absorption and metabolic conversion of dietary quercetin glucosides."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381981471408909954","@type":"Researcher","foaf:name":[{"@value":"Kaeko Murota"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981471408909953","@type":"Researcher","foaf:name":[{"@value":"Sumie Shimizu"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981471408909956","@type":"Researcher","foaf:name":[{"@value":"Hitomi Chujo"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981471408909952","@type":"Researcher","foaf:name":[{"@value":"Jae-Hak Moon"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981471408909955","@type":"Researcher","foaf:name":[{"@value":"Junji Terao"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00039861"}],"prism:publicationName":[{"@value":"Archives of Biochemistry and Biophysics"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2000-12","prism:volume":"384","prism:number":"2","prism:startingPage":"391","prism:endingPage":"397"},"reviewed":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S0003986100921234?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S0003986100921234?httpAccept=text/plain"}],"createdAt":"2002-09-16","modifiedAt":"2019-12-16","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Extracts","dc:title":"Cell Extracts"},{"@id":"https://cir.nii.ac.jp/all?q=Flavonols","dc:title":"Flavonols"},{"@id":"https://cir.nii.ac.jp/all?q=Intestinal%20Absorption","dc:title":"Intestinal Absorption"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Polarity","dc:title":"Cell Polarity"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Quercetin","dc:title":"Quercetin"},{"@id":"https://cir.nii.ac.jp/all?q=Caco-2%20Cells","dc:title":"Caco-2 Cells"},{"@id":"https://cir.nii.ac.jp/all?q=Intestinal%20Mucosa","dc:title":"Intestinal Mucosa"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050867133849018496","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"8-Prenylnaringenin tissue distribution and pharmacokinetics in mice and its binding to human serum albumin and cellular uptake in human embryonic kidney cells"},{"@value":"8‐Prenylnaringenin tissue distribution and pharmacokinetics in mice and its binding to human serum albumin and cellular uptake in human embryonic kidney cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004230227214464","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Plasma metabolites of dietary flavonoids after combination meal consumption with onion and tofu in humans"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285708554367744","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Immunomodulatory activity of enzymatically synthesized glycogen and its digested metabolite in a co-culture system consisting of differentiated Caco-2 cells and RAW264.7 macrophages"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565167232325504","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Flavonoid metabolism: the interaction of metabolites and gut microbiota"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567181889352832","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Lymphatic metabolites of quercetin after intestinal administration of quercetin-3-glucoside and its aglycone in rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846641537317248","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Absorption and Metabolism of Luteolin and Its Glycosides from the Extract of<i>Chrysanthemum morifolium</i>Flowers in Rats and Caco-2 Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848662495510528","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Quercetin Represses Apolipoprotein B Expression by Inhibiting the Transcriptional Activity of C/EBPβ"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848664681856384","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Prenylation Enhances Quercetin Uptake and Reduces Efflux in Caco-2 Cells and Enhances Tissue Accumulation in Mice Fed Long-Term"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204457787904","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Differential Effects of Cyanidin and Cyanidin-3-glucoside on Human Cell Lines"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001206325579264","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Absorption of Dietary Licorice Isoflavan Glabridin to Blood Circulation in Rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001206326417408","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Caffeine-Stimulated Intestinal Epithelial Cells Suppress Lipid Accumulation in Adipocytes"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001288085091840","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Inhibitory effect of catecholic colonic metabolites of rutin on fatty acid hydroperoxide and hemoglobin dependent lipid peroxidation in Caco-2 cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679397937024","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"フラボノイド類の血中代謝物と局所における有効性"},{"@language":"en","@value":"Circulating conjugated flavonoids and the sites of their metabolic activation"},{"@language":"ja-Kana","@value":"フラボノイドルイ ノ ケッチュウ タイシャブツ ト キョクショ ニ オケル ユウコウセイ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282681270535040","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Integrated Studies on the Action Mechanism of Oxidative Stress-regulating Food Bioactives"},{"@language":"ja","@value":"酸化ストレスを制御する食品機能成分の活性発現機構に関する統合研究"},{"@value":"酸化ストレスを制御する食品機能成分の活性発現機構に関する統合研究(平成26年度日本栄養・食糧学会学会賞受賞)"},{"@language":"ja-Kana","@value":"サンカ ストレス オ セイギョ スル ショクヒン キノウ セイブン ノ カッセイ ハツゲン キコウ ニ カンスル トウゴウ ケンキュウ(ヘイセイ 26ネンド ニホン エイヨウ ・ ショクリョウ ガッカイ ガッカイショウ ジュショウ)"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282681449999104","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Effect of Quercetin and Its Conjugated Metabolite on the Hydrogen Peroxide-induced Intracellular Production of Reactive Oxygen Species in Mouse Fibroblasts."}]},{"@id":"https://cir.nii.ac.jp/crid/2050025942007635584","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Estrogen- and stress-induced DNA damage in breast cancer and chemoprevention with dietary flavonoid"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1006/abbi.2000.2123"},{"@type":"OPENAIRE","@value":"doi_dedup___::bcd68a38bb49fd88353aa7f411fb2b9b"},{"@type":"CROSSREF","@value":"10.1002/mnfr.201300234_references_DOI_ShvamGM7bzKigJqKe5vcM2cWQzB"},{"@type":"CROSSREF","@value":"10.3164/jcbn.18-38_references_DOI_ShvamGM7bzKigJqKe5vcM2cWQzB"},{"@type":"CROSSREF","@value":"10.1039/c3fo60035a_references_DOI_ShvamGM7bzKigJqKe5vcM2cWQzB"},{"@type":"CROSSREF","@value":"10.3177/jnsv.53.358_references_DOI_ShvamGM7bzKigJqKe5vcM2cWQzB"},{"@type":"CROSSREF","@value":"10.1080/09168451.2018.1444467_references_DOI_ShvamGM7bzKigJqKe5vcM2cWQzB"},{"@type":"CROSSREF","@value":"10.1186/s41021-016-0071-7_references_DOI_ShvamGM7bzKigJqKe5vcM2cWQzB"},{"@type":"CROSSREF","@value":"10.1271/bbb.66.1015_references_DOI_ShvamGM7bzKigJqKe5vcM2cWQzB"},{"@type":"CROSSREF","@value":"10.1371/journal.pone.0121784_references_DOI_ShvamGM7bzKigJqKe5vcM2cWQzB"},{"@type":"CROSSREF","@value":"10.3945/jn.113.176818_references_DOI_ShvamGM7bzKigJqKe5vcM2cWQzB"},{"@type":"CROSSREF","@value":"10.1021/acs.jafc.5b00232_references_DOI_ShvamGM7bzKigJqKe5vcM2cWQzB"},{"@type":"CROSSREF","@value":"10.1016/j.abb.2018.03.024_references_DOI_ShvamGM7bzKigJqKe5vcM2cWQzB"},{"@type":"CROSSREF","@value":"10.3123/jems.26.241_references_DOI_ShvamGM7bzKigJqKe5vcM2cWQzB"},{"@type":"CROSSREF","@value":"10.3136/fstr.17.515_references_DOI_ShvamGM7bzKigJqKe5vcM2cWQzB"},{"@type":"CROSSREF","@value":"10.4327/jsnfs.68.3_references_DOI_ShvamGM7bzKigJqKe5vcM2cWQzB"},{"@type":"CROSSREF","@value":"10.1002/fsn3.2733_references_DOI_ShvamGM7bzKigJqKe5vcM2cWQzB"},{"@type":"CROSSREF","@value":"10.3177/jnsv.63.331_references_DOI_ShvamGM7bzKigJqKe5vcM2cWQzB"}]}