{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362257544070728832.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.3389/fmicb.2019.01326"}},{"identifier":{"@type":"URI","@value":"https://www.frontiersin.org/article/10.3389/fmicb.2019.01326/full"}},{"identifier":{"@type":"PMID","@value":"31275264"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Middle East Respiratory Syndrome Coronavirus in Dromedaries in Ethiopia Is Antigenically Different From the Middle East Isolate EMC"}],"description":[{"notation":[{"@value":"Middle East respiratory syndrome (MERS) is an emerging respiratory disease caused by the MERS coronavirus (MERS-CoV). MERS has been endemic to Saudi Arabia since 2012. The reservoir of MERS-CoV is the dromedary camel, suggesting that MERS is primarily a zoonotic disease. MERS-CoV is common in dromedaries throughout the Middle East, North Africa, and East Africa as evidenced by neutralizing antibodies against MERS-CoV; however, human cases have remained limited to the Middle East. To better understand the cause of this difference, the virological properties of African camel MERS-CoV were analyzed based on the spike (S) protein in Ethiopia. Nasal swabs were collected from 258 young dromedaries (≤ 2 years old) in the Afar region of Ethiopia, of which 39 were positive for MERS-CoV, as confirmed by genetic tests. All positive tests were exclusive to the Amibara woreda region. Using next-generation sequencing, two full-length genomes of Amibara isolates were successfully decoded; both isolates belonged to the C2 clade based on phylogenetic analysis of full-length and S protein sequences. Recombinant EMC isolates of MERS-CoV, in which the S protein is replaced with those of Amibara isolates, were then generated to test the roles of these proteins in viral properties. Amibara S recombinants replicated more slowly in cultured cells than in EMC S recombinants. In neutralizing assays, Amibara S recombinants were neutralized by lower concentrations of sera from both Ethiopian dromedaries and EMC isolate (wild-type)-immunized mouse sera, relative to the EMC S recombinants, indicating that viruses coated in the Amibara S protein were easier to neutralize than the EMC S protein. Neutralization experiments performed using S1/S2 chimeric recombinants of the EMC and Amibara S proteins showed that the neutralization profile was dependent on the S1 region of the S protein. These results suggest that the slower viral replication and the ease of neutralization seen in the Ethiopian MERS-CoV are due to strain-specific differences in the S protein and may account for the absence of human MERS-CoV cases in Ethiopia."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420282801197249792","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"40415477"},{"@type":"NRID","@value":"1000040415477"},{"@type":"NRID","@value":"9000413778259"},{"@type":"NRID","@value":"9000409645213"},{"@type":"NRID","@value":"9000411259397"},{"@type":"NRID","@value":"9000391901595"},{"@type":"NRID","@value":"9000412664935"},{"@type":"NRID","@value":"9000323830599"},{"@type":"NRID","@value":"9000015699145"},{"@type":"NRID","@value":"9000324651657"},{"@type":"NRID","@value":"9000410268220"},{"@type":"NRID","@value":"9000410874484"},{"@type":"NRID","@value":"9000414955185"},{"@type":"NRID","@value":"9000016885368"},{"@type":"NRID","@value":"9000005460239"},{"@type":"NRID","@value":"9000409028859"},{"@type":"NRID","@value":"9000291602217"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0103126"}],"foaf:name":[{"@value":"Kazuya Shirato"}]},{"@id":"https://cir.nii.ac.jp/crid/1382257544070729089","@type":"Researcher","foaf:name":[{"@value":"Simenew Keskes Melaku"}]},{"@id":"https://cir.nii.ac.jp/crid/1382257544070728965","@type":"Researcher","foaf:name":[{"@value":"Kengo Kawachi"}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751146705152","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"00781741"},{"@type":"NRID","@value":"1000000781741"},{"@type":"NRID","@value":"9000411259398"},{"@type":"NRID","@value":"9000259821861"},{"@type":"NRID","@value":"9000311069182"},{"@type":"NRID","@value":"9000404344460"},{"@type":"NRID","@value":"9000397945630"},{"@type":"NRID","@value":"9000378070982"},{"@type":"NRID","@value":"9000410268221"},{"@type":"NRID","@value":"9000340953639"},{"@type":"NRID","@value":"9000375912653"},{"@type":"NRID","@value":"9000244879587"},{"@type":"NRID","@value":"9000365496713"},{"@type":"NRID","@value":"9000318141831"},{"@type":"NRID","@value":"9000409028860"},{"@type":"NRID","@value":"9000375921547"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/54782569594485"}],"foaf:name":[{"@value":"Naganori Nao"}]},{"@id":"https://cir.nii.ac.jp/crid/1382257544070728969","@type":"Researcher","foaf:name":[{"@value":"Naoko Iwata-Yoshikawa"}]},{"@id":"https://cir.nii.ac.jp/crid/1382257544070729103","@type":"Researcher","foaf:name":[{"@value":"Miyuki Kawase"}]},{"@id":"https://cir.nii.ac.jp/crid/1382257544070729093","@type":"Researcher","foaf:name":[{"@value":"Wataru Kamitani"}]},{"@id":"https://cir.nii.ac.jp/crid/1382257544070728833","@type":"Researcher","foaf:name":[{"@value":"Shutoku Matsuyama"}]},{"@id":"https://cir.nii.ac.jp/crid/1382257544070729101","@type":"Researcher","foaf:name":[{"@value":"Tesfaye Sisay Tessema"}]},{"@id":"https://cir.nii.ac.jp/crid/1382257544070728967","@type":"Researcher","foaf:name":[{"@value":"Hiroshi Sentsui"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"1664302X"}],"prism:publicationName":[{"@value":"Frontiers in Microbiology"}],"dc:publisher":[{"@value":"Frontiers Media SA"}],"prism:publicationDate":"2019-06-19","prism:volume":"10"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://creativecommons.org/licenses/by/4.0/"],"url":[{"@id":"https://www.frontiersin.org/article/10.3389/fmicb.2019.01326/full"}],"createdAt":"2019-06-19","modifiedAt":"2021-01-06","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=dromedary","dc:title":"dromedary"},{"@id":"https://cir.nii.ac.jp/all?q=Middle%20East%20respiratory%20syndrome","dc:title":"Middle East respiratory syndrome"},{"@id":"https://cir.nii.ac.jp/all?q=antigenicity","dc:title":"antigenicity"},{"@id":"https://cir.nii.ac.jp/all?q=Ethiopia","dc:title":"Ethiopia"},{"@id":"https://cir.nii.ac.jp/all?q=neutralization","dc:title":"neutralization"},{"@id":"https://cir.nii.ac.jp/all?q=Microbiology","dc:title":"Microbiology"},{"@id":"https://cir.nii.ac.jp/all?q=Middle%20East%20respiratory%20syndrome%20coronavirus","dc:title":"Middle East respiratory syndrome coronavirus"},{"@id":"https://cir.nii.ac.jp/all?q=QR1-502","dc:title":"QR1-502"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000781958096256","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"17H04642"},{"@type":"JGN","@value":"JP17H04642"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17H04642/"}],"notation":[{"@language":"ja","@value":"エチオピアにおけるヒトコブラクダの中東呼吸器症候群コロナウイルスの調査"},{"@language":"en","@value":"Studies on the Middle East Respiratory Coronavirus in dromedary camels in Ethiopia"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004235985894400","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Middle East Respiratory Syndrome Coronavirus Spike Protein Is Not Activated Directly by Cellular Furin during Viral Entry into Target Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283691171263104","@type":"Article","resourceType":"学術雑誌論文(journal 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