{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362257544078723712.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.3389/fnins.2019.00905"}},{"identifier":{"@type":"URI","@value":"https://www.frontiersin.org/article/10.3389/fnins.2019.00905/full"}},{"identifier":{"@type":"PMID","@value":"31555076"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Leucine-Rich Repeat Kinase 2 Is Associated With Activation of the Paraventricular Nucleus of the Hypothalamus and Stress-Related Gastrointestinal Dysmotility"}],"description":[{"notation":[{"@value":"Leucine-rich repeat kinase 2 (LRRK2) is a molecule associated with familial and sporadic Parkinson's disease. It regulates many central neuronal functions, such as cell proliferation, apoptosis, autophagy, and axonal extension. Recently, it has been revealed that LRRK2 is related to anxiety/depression-like behavior, implying an association between LRRK2 and stress. In the present study, we investigated for the first time the stress pathway and its relationship to gastrointestinal motility in LRRK2-knockout (KO) mice. The mice were subjected to acute restraint stress, and analyzed for activation of the paraventricular nucleus of the hypothalamus (PVN) using an immunohistochemical approach. Phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2) was assessed by Western blotting. The KO mice showed a lower number of c-Fos-positive cells and disruption of the ERK signaling pathway in the PVN in the presence of restraint stress. Stress responses in terms of both upper and lower gastrointestinal motility were alleviated in the mice, accompanied by lower c-Fos immunoreactivity in enteric excitatory neurons. Our present findings suggest that LRRK2 is a newly recognized molecule regulating the stress pathway in the PVN, playing a role in stress-related gastrointestinal dysmotility."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420564276184337024","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"30647673"},{"@type":"NRID","@value":"1000030647673"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/maekawa_t"}],"foaf:name":[{"@value":"Tatsunori Maekawa"}]},{"@id":"https://cir.nii.ac.jp/crid/1382257544078723462","@type":"Researcher","foaf:name":[{"@value":"Hiromichi Tsushima"}]},{"@id":"https://cir.nii.ac.jp/crid/1420564276164126080","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"50511896"},{"@type":"NRID","@value":"1000050511896"},{"@type":"NRID","@value":"9000261040562"},{"@type":"NRID","@value":"9000253182827"},{"@type":"NRID","@value":"9000005116344"},{"@type":"NRID","@value":"9000005125458"},{"@type":"NRID","@value":"9000410628479"},{"@type":"NRID","@value":"9000389551843"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/kawakami82"}],"foaf:name":[{"@value":"Fumitaka Kawakami"}]},{"@id":"https://cir.nii.ac.jp/crid/1420001326234943360","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"70392389"},{"@type":"NRID","@value":"1000070392389"},{"@type":"NRID","@value":"9000005459733"},{"@type":"NRID","@value":"9000270285593"},{"@type":"NRID","@value":"9000408777161"},{"@type":"NRID","@value":"9000410628482"},{"@type":"NRID","@value":"9000017225352"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/reikawashima"}],"foaf:name":[{"@value":"Rei Kawashima"}]},{"@id":"https://cir.nii.ac.jp/crid/1382257544078723723","@type":"Researcher","foaf:name":[{"@value":"Masaru Kodo"}]},{"@id":"https://cir.nii.ac.jp/crid/1382257544078723718","@type":"Researcher","foaf:name":[{"@value":"Motoki Imai"}]},{"@id":"https://cir.nii.ac.jp/crid/1382257544078723586","@type":"Researcher","foaf:name":[{"@value":"Takafumi Ichikawa"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"1662453X"}],"prism:publicationName":[{"@value":"Frontiers in Neuroscience"}],"dc:publisher":[{"@value":"Frontiers Media SA"}],"prism:publicationDate":"2019-08-29","prism:volume":"13","prism:startingPage":"905"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://creativecommons.org/licenses/by/4.0/"],"url":[{"@id":"https://www.frontiersin.org/article/10.3389/fnins.2019.00905/full"}],"createdAt":"2019-08-29","modifiedAt":"2019-08-29","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=stress","dc:title":"stress"},{"@id":"https://cir.nii.ac.jp/all?q=signaling/signaling%20pathway","dc:title":"signaling/signaling pathway"},{"@id":"https://cir.nii.ac.jp/all?q=gut%20dysmotility","dc:title":"gut dysmotility"},{"@id":"https://cir.nii.ac.jp/all?q=paraventricular","dc:title":"paraventricular"},{"@id":"https://cir.nii.ac.jp/all?q=LRRK2","dc:title":"LRRK2"},{"@id":"https://cir.nii.ac.jp/all?q=Neurosciences.%20Biological%20psychiatry.%20Neuropsychiatry","dc:title":"Neurosciences. Biological psychiatry. Neuropsychiatry"},{"@id":"https://cir.nii.ac.jp/all?q=RC321-571","dc:title":"RC321-571"},{"@id":"https://cir.nii.ac.jp/all?q=Neuroscience","dc:title":"Neuroscience"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782004292864","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"18K15374"},{"@type":"JGN","@value":"JP18K15374"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K15374/"}],"notation":[{"@language":"ja","@value":"パーキンソン病原因分子LRRK2の変異による腸管神経障害機構の解明"},{"@language":"en","@value":"The role of LRRK2 in dysfunction of enteric nervous system"}]},{"@id":"https://cir.nii.ac.jp/crid/1040000782019262336","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"19K08379"},{"@type":"JGN","@value":"JP19K08379"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K08379/"}],"notation":[{"@language":"ja","@value":"アミノ酸トランスポーターに着眼した腸管粘膜の炎症マーカーとしての可能性"},{"@language":"en","@value":"Potential of amino acid transporter as a marker for inflammation of intestinal mucosa"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282256891694976","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"16K09323"},{"@type":"JGN","@value":"JP16K09323"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K09323/"}],"notation":[{"@language":"ja","@value":"小腸を対象としたヒスタミンH2受容体の傷害制御"},{"@language":"en","@value":"Regulation of the injury via the histamine H2 receptor pathway in the small intestine"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282256945058688","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"17K09392"},{"@type":"JGN","@value":"JP17K09392"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K09392/"}],"notation":[{"@language":"ja","@value":"病態依存的に変動する腸管ムチンの水分保持機構の解明"},{"@language":"en","@value":"Mechanisms of the water retention into the intestinal mucin that fluctuates depending on the pathological condition"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004235804109952","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Enteric glial cells are associated with stress‐induced colonic hyper‐contraction in maternally separated rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011144186131712","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Genomewide Association Study of Leprosy"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011144545405312","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Nonmotor Symptoms in LRRK2 G2019S Associated Parkinson’s Disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145131728000","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Leucine-rich repeat kinase 2 controls protein kinase A activation state through phosphodiesterase 4"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145633867904","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"RAB7L1 Interacts with LRRK2 to Modify Intraneuronal Protein Sorting and Parkinson’s Disease Risk"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011146399787648","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Ca\n                    <sub>v</sub>\n                    3.2 T-Type Ca\n                    <sup>2+</sup>\n                    Channel-Dependent Activation of ERK in Paraventricular Thalamus Modulates Acid-Induced Chronic Muscle Pain"}]},{"@id":"https://cir.nii.ac.jp/crid/1360025430632087552","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Biphenotypic Cells and α-Synuclein Accumulation in Enteric Neurons of Leucine-Rich Repeat Kinase 2 Knockout Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360282588975426304","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A new locus for Parkinson's disease (<i>PARK8</i>) maps to chromosome 12p11.2–q13.1"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285707275230464","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Leucine-rich repeat kinase 2 is a regulator of B cell function, affecting homeostasis, BCR signaling, IgA production, and TI antigen responses"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285711791188480","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Leucine-rich repeat kinase 2 (LRRK2) regulates α-synuclein clearance in microglia"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619268571136","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cyto‐ and chemoarchitecture of the hypothalamic paraventricular nucleus in the C57BL/6J male mouse: A study of immunostaining and multiple fluorescent tract tracing"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619553128192","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"LRRK2 is expressed in B-2 but not in B-1 B cells, and downregulated by cellular activation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619880548480","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Stress modulates intestinal secretory immunoglobulin A"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620853443200","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292621427738752","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574093475288192","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"An early endosome regulator, Rab5b, is an LRRK2 kinase substrate"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095578709248","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cross-talk between LRRK2 and PKA: implication for Parkinson's disease?"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855567868857088","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570616484352","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"LRRK2 Controls an EndoA Phosphorylation Cycle in Synaptic Endocytosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360857593779982336","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Oxytocin antagonist induced visceral pain and corticotropin-releasing hormone neuronal activation in the central nucleus of the amygdala during colorectal distention in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045180789888","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"LRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activity"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418518390374016","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"LRRK2 functions as a scaffolding kinase of ASK1-mediated neuronal cell death"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519187928704","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Neuroendocrinology of Stress: A Never Ending Story"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519294229504","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Linkage disequilibrium and haplotype tagging polymorphisms in the Tau H1 haplotype"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699993482940672","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Enteric <scp>GFAP</scp> expression and phosphorylation in Parkinson's disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994441367936","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Ghrelin Regulates Glucose and Glutamate Transporters in Hypothalamic Astrocytes"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994454568832","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Distribution of PINK1 and LRRK2 in rat and mouse brain"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994661936768","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Parkinson disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995660596864","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Enteric Glia: Identity and Functions"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469319654272","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Comprehensive characterization and optimization of anti-LRRK2 (leucine-rich repeat kinase 2) monoclonal antibodies"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469734804096","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Characterization of Corticotropin-Releasing Hormone neurons in the Paraventricular Nucleus of the Hypothalamus of Crh-IRES-Cre Mutant Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981470642010240","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262946080022912","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"LRRK2 G2019S Induces Anxiety/Depression-like Behavior before the Onset of Motor Dysfunction with 5-HT<sub>1A</sub>Receptor Upregulation in Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544418866467712","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Phosphorylation of LRRK2: from kinase to substrate"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419424905472","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Gastric motor dysfunctions in Parkinson's disease: Current pre-clinical evidence"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419716318208","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Regulation of the Hypothalamic‐Pituitary‐Adrenocortical Stress Response"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419889931648","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Corticotropin‐Releasing Factor and the Brain‐Gut Motor Response to Stress"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420910631296","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The effect of LRRK2 mutations on the cholinergic system in manifest and premanifest stages of Parkinson's disease: a cross-sectional PET study"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895996185472","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825896133244928","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cross Talk between ERK and PKA Is Required for Ca2+ Stimulation of CREB-Dependent Transcription and ERK Nuclear Translocation"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107368459585792","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Local Corticotropin-Releasing Factor Signaling in the Hypothalamic Paraventricular Nucleus"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107368624378240","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Roles of the Drosophila LRRK2 homolog in Rab7-dependent lysosomal positioning"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107368662190080","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cloning of the Gene Containing Mutations that Cause PARK8-Linked Parkinson's Disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107369684471552","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Disruption of Maternal Parenting Circuitry by Addictive Process: Rewiring of Reward and Stress Systems"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107370836276096","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Development of the HPA axis: Where and when do sex differences manifest?"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107370961031296","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Effects of repeated restraint stress on gastric motility in rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388843250380672","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Role of LRRK2 in the regulation of dopamine receptor trafficking"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844842241920","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The effect of single or repeated restraint stress on several signal molecules in paraventricular nucleus, arcuate nucleus and locus coeruleus"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388845509501952","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"cAMP-dependent Protein Kinase Induces cAMP-response Element-binding Protein Phosphorylation via an Intracellular Calcium Release/ERK-dependent Pathway in Striatal Neurons"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388845685330816","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Regulation of the Transcriptional Activity of c-Fos by ERK"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388846251783680","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Expression and localization of Parkinson's disease‐associated leucine‐rich repeat kinase 2 in the mouse brain"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670318548766848","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Relationship of functional gastrointestinal disorders and psychiatric disorders: Implications for treatment"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670319275115008","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Wild-type LRRK2 but not its mutant attenuates stress-induced cell death via ERK pathway"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670319402697344","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Leucine‐rich repeat kinase 2 regulates Sec16A at\n                    <scp>ER</scp>\n                    exit sites to allow\n                    <scp>ER</scp>\n                    –Golgi export"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320149392512","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"LRRK2, a puzzling protein: Insights into Parkinson's disease pathogenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320511113856","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"LRRK2 is expressed in areas affected by Parkinson's disease in the adult mouse brain"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951794119452160","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Enteric Glial Cells: Recent Developments and Future Directions"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951794179970560","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Phenotype in parkinsonian and nonparkinsonian\n            <i>LRRK2</i>\n            G2019S mutation carriers"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951794406908160","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The RIP kinases: crucial integrators of cellular stress"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233268320783872","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Tonic, But Not Phasic Corticosterone, Constrains Stress ActivatedExtracellular-Regulated-Kinase 1/ 2 Immunoreactivity Within the Hypothalamic Paraventricular Nucleus"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233269095135360","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"LRRK2 Inhibition Attenuates Microglial Inflammatory Responses"}]},{"@id":"https://cir.nii.ac.jp/crid/1372257544078723328","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Stress and the gut: pathophysiology, clinical consequences, diagnostic approach and treatment options."}]},{"@id":"https://cir.nii.ac.jp/crid/1372257544078723339","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Neural pathways of stress integration: relevance to alcohol abuse."}]},{"@id":"https://cir.nii.ac.jp/crid/1372257544078723585","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"LRRK2: an emerging new molecule in the enteric neuronal system that quantitatively regulates neuronal peptides and iga in the gut."}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.3389/fnins.2019.00905"},{"@type":"KAKEN","@value":"PRODUCT-22647043"},{"@type":"KAKEN","@value":"PRODUCT-23101151"},{"@type":"KAKEN","@value":"PRODUCT-22739295"},{"@type":"KAKEN","@value":"PRODUCT-23032184"},{"@type":"OPENAIRE","@value":"doi_dedup___::86c8e928eeba3a94b96edc2c988c7b72"},{"@type":"CROSSREF","@value":"10.1007/s10620-024-08494-7_references_DOI_7kVztqRYp20hPesYeMJUo6eVP72"},{"@type":"CROSSREF","@value":"10.1016/j.neures.2021.04.011_references_DOI_7kVztqRYp20hPesYeMJUo6eVP72"}]}