{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362257544103894784.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.3390/cancers12051135"}},{"identifier":{"@type":"URI","@value":"https://www.mdpi.com/2072-6694/12/5/1135/pdf"}},{"identifier":{"@type":"PMID","@value":"32369927"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Prospects for Comprehensive Analyses of Circulating Tumor Cells in Tumor Biology"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>The comprehensive analysis of biological and clinical aspects of circulating tumor cells (CTCs) has attracted interest as a means of enabling non-invasive, real-time monitoring of cancer patients and enhancing our fundamental understanding of tumor metastasis. However, CTC populations are extremely small when compared to other cell populations in the blood, limiting our comprehension of CTC biology and their clinical utility. Recently developed proteomic and genomic techniques that require only a small amount of sample have attracted much interest and expanded the potential utility of CTCs. Cancer heterogeneity, including specific mutations, greatly impacts disease diagnosis and the choice of available therapeutic strategies. The CTC population consists primarily of cancer stem cells, and CTC subpopulations are thought to undergo epithelial–mesenchymal transition during dissemination. To better characterize tumor cell populations, we demonstrated that changes in genomic profiles identified via next-generation sequencing of liquid biopsy samples could be expanded upon to increase sensitivity without decreasing specificity by using a combination of assays with CTCs and circulating tumor DNA. To enhance our understanding of CTC biology, we developed a metabolome analysis method applicable to single CTCs. Here, we review―omics studies related to CTC analysis and discuss various clinical and biological issues related to CTCs.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382257544103894528","@type":"Researcher","foaf:name":[{"@value":"Masahiko Aoki"}],"jpcoar:affiliationName":[{"@value":"Department of Biomarkers for Early Detection of Cancer, National Cancer Center Research Institute, Tokyo 104-0045, Japan"},{"@value":"Gastrointestinal Medical Oncology Division, National Cancer Center Hospital, Tokyo 104-0045, Japan"},{"@value":"Internal Medicine (II), Osaka Medical College, Osaka 569-8686, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1420564276175517056","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"50765568"},{"@type":"NRID","@value":"1000050765568"},{"@type":"NRID","@value":"9000399770103"}],"foaf:name":[{"@value":"Hirokazu Shoji"}],"jpcoar:affiliationName":[{"@value":"Gastrointestinal Medical Oncology Division, National Cancer Center Hospital, Tokyo 104-0045, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1382257544103894657","@type":"Researcher","foaf:name":[{"@value":"Ayumi Kashiro"}],"jpcoar:affiliationName":[{"@value":"Department of Biomarkers for Early Detection of Cancer, National Cancer Center Research Institute, Tokyo 104-0045, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1382257544103894786","@type":"Researcher","foaf:name":[{"@value":"Keiko Takeuchi"}],"jpcoar:affiliationName":[{"@value":"Department of Biomarkers for Early Detection of Cancer, National Cancer Center Research Institute, Tokyo 104-0045, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1382257544103894912","@type":"Researcher","foaf:name":[{"@value":"Yoshihiro Shimizu"}],"jpcoar:affiliationName":[{"@value":"RIKEN Center for Biosystems Dynamics research (BDR), Osaka 565-0874, 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Honda"}],"jpcoar:affiliationName":[{"@value":"Department of Biomarkers for Early Detection of Cancer, National Cancer Center Research Institute, Tokyo 104-0045, Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"20726694"}],"prism:publicationName":[{"@value":"Cancers"}],"dc:publisher":[{"@value":"MDPI 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