{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362262943427016192.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.neures.2006.11.004"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0168010206002987?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0168010206002987?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"17156878"}}],"dc:title":[{"@value":"Change with age in muscular mechanical hyperalgesia after lengthening contraction in rats"}],"description":[{"notation":[{"@value":"To determine whether there is any change by aging in mechanical hyperalgesia (delayed onset muscle soreness) after lengthening contraction (LC, also termed as eccentric contraction), we applied LC to the dorsi-flexors of the hind legs in young (7-week-old) and aged (130-week-old) rats and examined the change in mechanical withdrawal threshold of the exercised muscle with a Randall-Selitto apparatus and by c-Fos expression in the dorsal horn. The baseline mechanical withdrawal threshold did not differ among two age groups. One day after LC the withdrawal threshold started to decrease in both age groups, however, the duration of decreased withdrawal threshold was different: young rats had their withdrawal threshold lowered only for 3 days after LC while that of aged rats remained lowered two more days, showing delayed recovery in aged rats. Induction of c-Fos expression in the spinal dorsal horn by compression of the muscle was examined in aged animals 3 days after LC. Significantly larger numbers of c-Fos positive neurons was observed in the superficial dorsal horn than the control animals (no treatment). This increase was observed not only in L4 but also in L5, a wider distribution than in young animals (L4 only) in our previous report [Taguchi, T., Matsuda, T., Tamura, R., Sato, J., Mizumura, K., 2005a. Muscular mechanical hyperalgesia revealed by behavioural pain test and c-Fos expression in the spinal dorsal horn after eccentric contraction in rats."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382262943427016194","@type":"Researcher","foaf:name":[{"@value":"Toru Taguchi"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943427016193","@type":"Researcher","foaf:name":[{"@value":"Teru Matsuda"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943427016192","@type":"Researcher","foaf:name":[{"@value":"Kazue Mizumura"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"01680102"}],"prism:publicationName":[{"@value":"Neuroscience Research"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2007-03","prism:volume":"57","prism:number":"3","prism:startingPage":"331","prism:endingPage":"338"},"reviewed":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","https://www.elsevier.com/legal/tdmrep-license"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S0168010206002987?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S0168010206002987?httpAccept=text/plain"}],"createdAt":"2006-12-07","modifiedAt":"2025-09-29","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Pain%20Threshold","dc:title":"Pain Threshold"},{"@id":"https://cir.nii.ac.jp/all?q=Afferent%20Pathways","dc:title":"Afferent Pathways"},{"@id":"https://cir.nii.ac.jp/all?q=Aging","dc:title":"Aging"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Count","dc:title":"Cell Count"},{"@id":"https://cir.nii.ac.jp/all?q=Rats","dc:title":"Rats"},{"@id":"https://cir.nii.ac.jp/all?q=Up-Regulation","dc:title":"Up-Regulation"},{"@id":"https://cir.nii.ac.jp/all?q=Posterior%20Horn%20Cells","dc:title":"Posterior Horn Cells"},{"@id":"https://cir.nii.ac.jp/all?q=Rats,%20Sprague-Dawley","dc:title":"Rats, Sprague-Dawley"},{"@id":"https://cir.nii.ac.jp/all?q=Hyperalgesia","dc:title":"Hyperalgesia"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Muscle,%20Skeletal","dc:title":"Muscle, Skeletal"},{"@id":"https://cir.nii.ac.jp/all?q=Proto-Oncogene%20Proteins%20c-fos","dc:title":"Proto-Oncogene Proteins c-fos"},{"@id":"https://cir.nii.ac.jp/all?q=Biomarkers","dc:title":"Biomarkers"},{"@id":"https://cir.nii.ac.jp/all?q=Muscle%20Contraction","dc:title":"Muscle Contraction"},{"@id":"https://cir.nii.ac.jp/all?q=Pain%20Measurement","dc:title":"Pain Measurement"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360002215499387392","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Delayed onset muscle soreness: Involvement of neurotrophic factors"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285710799718400","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Decreased nerve growth factor upregulation is a mechanism for reduced mechanical hyperalgesia after the second bout of exercise in rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1360299458341080064","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Neurochemical mechanism of muscular pain: Insight from the study on delayed onset muscle soreness"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848657046291328","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Augmented mechanical response of muscular thin‐fiber receptors in aged rats recorded <i>in vitro</i>"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1016/j.neures.2006.11.004"},{"@type":"OPENAIRE","@value":"doi_dedup___::198d5fc27568bda632bdf532fb81a90d"},{"@type":"CROSSREF","@value":"10.1007/s12576-015-0397-0_references_DOI_ROo4EosDrLEcT5HSqDwytgZ45AJ"},{"@type":"CROSSREF","@value":"10.1111/sms.12013_references_DOI_ROo4EosDrLEcT5HSqDwytgZ45AJ"},{"@type":"CROSSREF","@value":"10.1186/s12576-023-00896-y_references_DOI_ROo4EosDrLEcT5HSqDwytgZ45AJ"},{"@type":"CROSSREF","@value":"10.1016/j.ejpain.2010.08.007_references_DOI_ROo4EosDrLEcT5HSqDwytgZ45AJ"}]}