{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362262943501531776.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1111/all.13749"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/all.13749"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/full-xml/10.1111/all.13749"}},{"identifier":{"@type":"PMID","@value":"31095767"}},{"identifier":{"@type":"HANDLE","@value":"10807/171589"}},{"identifier":{"@type":"HANDLE","@value":"11570/3143581"}}],"dc:title":[{"@value":"<scp>EAACI</scp> Guidelines on Allergen Immunotherapy: House dust mite‐driven allergic asthma"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:p>Allergen immunotherapy (<jats:styled-content style=\"fixed-case\">AIT</jats:styled-content>) has been in use for the treatment of allergic disease for more than 100 years. Asthma treatment relies mainly on corticosteroids and other controllers recommended to achieve and maintain asthma control, prevent exacerbations, and improve quality of life. <jats:styled-content style=\"fixed-case\">AIT</jats:styled-content> is underused in asthma, both in children and in adults. Notably, patients with allergic asthma not adequately controlled on pharmacotherapy (including biologics) represent an unmet health need. The European Academy of Allergy and Clinical Immunology has developed a clinical practice guideline providing evidence‐based recommendations for the use of house dust mites (<jats:styled-content style=\"fixed-case\">HDM</jats:styled-content>) <jats:styled-content style=\"fixed-case\">AIT</jats:styled-content> as add‐on treatment for <jats:styled-content style=\"fixed-case\">HDM</jats:styled-content>‐driven allergic asthma. This guideline was developed by a multi‐disciplinary working group using the Grading of Recommendations Assessment, Development and Evaluation (<jats:styled-content style=\"fixed-case\">GRADE</jats:styled-content>) approach. <jats:styled-content style=\"fixed-case\">HDM AIT</jats:styled-content> was separately evaluated by route of administration and children and adults: subcutaneous (<jats:styled-content style=\"fixed-case\">SCIT</jats:styled-content>) and sublingual <jats:styled-content style=\"fixed-case\">AIT</jats:styled-content> (<jats:styled-content style=\"fixed-case\">SLIT</jats:styled-content>), drops, and tablets. Recommendations were formulated for each. The important prerequisites for successful treatment with <jats:styled-content style=\"fixed-case\">HDM AIT</jats:styled-content> are (a) selection of patients most likely to respond to <jats:styled-content style=\"fixed-case\">AIT</jats:styled-content> and (b) use of allergen extracts and desensitization protocols of proven efficacy. To date, only <jats:styled-content style=\"fixed-case\">AIT</jats:styled-content> with <jats:styled-content style=\"fixed-case\">HDM SLIT</jats:styled-content>‐tablet has demonstrated a robust effect in adults for critical end points (exacerbations, asthma control, and safety). Thus, it is recommended as an add‐on to regular asthma therapy for adults with controlled or partially controlled <jats:styled-content style=\"fixed-case\">HDM</jats:styled-content>‐driven allergic asthma (conditional recommendation, moderate‐quality evidence). <jats:styled-content style=\"fixed-case\">HDM SCIT</jats:styled-content> is recommended for adults and children, and <jats:styled-content style=\"fixed-case\">SLIT</jats:styled-content> drops are recommended for children with controlled <jats:styled-content style=\"fixed-case\">HDM</jats:styled-content>‐driven allergic asthma as the add‐on to regular asthma therapy to decrease symptoms and medication needs (conditional recommendation, low‐quality evidence).</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382262943501531779","@type":"Researcher","foaf:name":[{"@value":"Ioana Agache"}],"jpcoar:affiliationName":[{"@value":"Faculty of Medicine Department of Allergy and Clinical Immunology Transylvania University Brasov Brasov Romania"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943501531785","@type":"Researcher","foaf:name":[{"@value":"Susanne Lau"}],"jpcoar:affiliationName":[{"@value":"Department for Pediatric Pneumology, Immunology and Intensive Care Charité Universität Medizin Berlin Germany"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943501531654","@type":"Researcher","foaf:name":[{"@value":"Cezmi A. Akdis"}],"jpcoar:affiliationName":[{"@value":"University of Zürich Swiss Institute of Allergy and Asthma Research (SIAF) Davos Switzerland"},{"@value":"Christine Kühne‐Center for Allergy Research and Education (CK‐CARE) Davos Switzerland"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943501531648","@type":"Researcher","foaf:name":[{"@value":"Sylwia Smolinska"}],"jpcoar:affiliationName":[{"@value":"Department of Clinical Immunology Wroclaw Medical University Wroclaw Poland"},{"@value":"“ALL‐MED” Medical Research Institute Wroclaw Poland"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943501531656","@type":"Researcher","foaf:name":[{"@value":"Matteo Bonini"}],"jpcoar:affiliationName":[{"@value":"National Heart and Lung Institute (NHLI) Royal Brompton Hospital & Imperial College London UK"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943501531649","@type":"Researcher","foaf:name":[{"@value":"Ozlem Cavkaytar"}],"jpcoar:affiliationName":[{"@value":"Faculty of Medicine Department of Pediatric Allergy Istanbul Medeniyet University Goztepe Training and Research Hospital Istanbul Turkey"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943501531784","@type":"Researcher","foaf:name":[{"@value":"Breda Flood"}],"jpcoar:affiliationName":[{"@value":"European Federation of Allergy and Airways Diseases, Patients Association Brussels Belgium"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943501531776","@type":"Researcher","foaf:name":[{"@value":"Pawe Gajdanowicz"}],"jpcoar:affiliationName":[{"@value":"Department of Clinical Immunology Wroclaw Medical University Wroclaw Poland"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943501531787","@type":"Researcher","foaf:name":[{"@value":"Kenji Izuhara"}],"jpcoar:affiliationName":[{"@value":"Saga Medical School Saga Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943501531651","@type":"Researcher","foaf:name":[{"@value":"Omer Kalayci"}],"jpcoar:affiliationName":[{"@value":"Hacettepe University School of Medicine Ankara Turkey"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943501531786","@type":"Researcher","foaf:name":[{"@value":"Ralph Mosges"}],"jpcoar:affiliationName":[{"@value":"Universität zu Koln Institute of Medical Statistics, Informatics and Epidemiology (IMSIE) Koln Germany"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943501531778","@type":"Researcher","foaf:name":[{"@value":"Oscar Palomares"}],"jpcoar:affiliationName":[{"@value":"Department of Biochemistry and Molecular Biology Complutense University of Madrid Madrid Spain"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943501531782","@type":"Researcher","foaf:name":[{"@value":"Nikolaos G. Papadopoulos"}],"jpcoar:affiliationName":[{"@value":"Division of Infection, Immunity and respiratory medicine University of Manchester Manchester UK"},{"@value":"Allergy Department 2nd Pediatric Clinic University of Athens Athens Greece"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943501531781","@type":"Researcher","foaf:name":[{"@value":"Milena Sokolowska"}],"jpcoar:affiliationName":[{"@value":"University of Zürich Swiss Institute of Allergy and Asthma Research (SIAF) Davos Switzerland"},{"@value":"Christine Kühne‐Center for Allergy Research and Education (CK‐CARE) Davos Switzerland"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943501531655","@type":"Researcher","foaf:name":[{"@value":"Elisabeth Angier"}],"jpcoar:affiliationName":[{"@value":"Faculty of Medicine University of Southampton Southampton UK"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943501531661","@type":"Researcher","foaf:name":[{"@value":"Montserrat Fernandez‐Rivas"}],"jpcoar:affiliationName":[{"@value":"Allergy Department Hospital Clinico San Carlos, IdISSC Madrid Spain"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943501531650","@type":"Researcher","foaf:name":[{"@value":"Giovanni Pajno"}],"jpcoar:affiliationName":[{"@value":"Allergy Unit Department of Pediatrics University of Messina Messina Italy"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943501531783","@type":"Researcher","foaf:name":[{"@value":"Oliver Pfaar"}],"jpcoar:affiliationName":[{"@value":"Department of Otorhinolaryngology, Head and Neck Surgery Section of Rhinology and Allergy University Hospital Marburg Philipps‐Universität Marburg Marburg Germany"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943501531652","@type":"Researcher","foaf:name":[{"@value":"Graham C. Roberts"}],"jpcoar:affiliationName":[{"@value":"The David Hide Asthma and Allergy Research Centre St Mary's Hospital Newport Isle of Wight UK"},{"@value":"NIHR Biomedical Research Centre University Hospital Southampton NHS Foundation Trust Southampton UK"},{"@value":"Faculty of Medicine University of Southampton Southampton UK"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943501531657","@type":"Researcher","foaf:name":[{"@value":"Dermot Ryan"}],"jpcoar:affiliationName":[{"@value":"Usher Institute of Population Health Sciences and Informatics University of Edinburgh Edinburgh UK"},{"@value":"Asthma UK Centre for Applied Research The University of Edinburgh Edinburgh UK"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943501531659","@type":"Researcher","foaf:name":[{"@value":"Gunter J. Sturm"}],"jpcoar:affiliationName":[{"@value":"Department of Dermatology and Venerology Medical University of Graz Graz Austria"},{"@value":"Outpatient Allergy Clinic Reumannplaz Vienna Austria"}]},{"@id":"https://cir.nii.ac.jp/crid/1380298341498982912","@type":"Researcher","foaf:name":[{"@value":"Ronald van Ree"}],"jpcoar:affiliationName":[{"@value":"Department of Experimental Immunology Academic Medical Center University of Amsterdam Amsterdam The Netherlands"},{"@value":"Department of Otorhinolaryngology Academic Medical Center University of Amsterdam Amsterdam The Netherlands"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943501531780","@type":"Researcher","foaf:name":[{"@value":"Eva M. Varga"}],"jpcoar:affiliationName":[{"@value":"Department of Pediatric and Adolescent Medicine Respiratory and Allergic Disease Division Medical University of Graz Graz Austria"}]},{"@id":"https://cir.nii.ac.jp/crid/1380298341498982913","@type":"Researcher","foaf:name":[{"@value":"Roy Gerth van Wijk"}],"jpcoar:affiliationName":[{"@value":"Section of Allergology Department of Internal Medicine Erasmus Medical Center Rotterdam The Netherlands"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943501531653","@type":"Researcher","foaf:name":[{"@value":"Juan José Yepes‐Nuñez"}],"jpcoar:affiliationName":[{"@value":"School of Medicine Universidad de Los Andes Bogotá Colombia"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943501531660","@type":"Researcher","foaf:name":[{"@value":"Marek Jutel"}],"jpcoar:affiliationName":[{"@value":"Department of Clinical Immunology Wroclaw Medical University Wroclaw Poland"},{"@value":"“ALL‐MED” Medical Research Institute Wroclaw Poland"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"01054538"},{"@type":"EISSN","@value":"13989995"}],"prism:publicationName":[{"@value":"Allergy"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2019-05","prism:volume":"74","prism:number":"5","prism:startingPage":"855","prism:endingPage":"873"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/all.13749"},{"@id":"https://onlinelibrary.wiley.com/doi/full-xml/10.1111/all.13749"}],"createdAt":"2019-05-16","modifiedAt":"2023-09-10","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Pyroglyphidae","dc:title":"Pyroglyphidae"},{"@id":"https://cir.nii.ac.jp/all?q=610","dc:title":"610"},{"@id":"https://cir.nii.ac.jp/all?q=lung%20function","dc:title":"lung function"},{"@id":"https://cir.nii.ac.jp/all?q=ddc:no","dc:title":"ddc:no"},{"@id":"https://cir.nii.ac.jp/all?q=asthma","dc:title":"asthma"},{"@id":"https://cir.nii.ac.jp/all?q=Allergens","dc:title":"Allergens"},{"@id":"https://cir.nii.ac.jp/all?q=allergy","dc:title":"allergy"},{"@id":"https://cir.nii.ac.jp/all?q=Asthma","dc:title":"Asthma"},{"@id":"https://cir.nii.ac.jp/all?q=asthma%20control","dc:title":"asthma control"},{"@id":"https://cir.nii.ac.jp/all?q=GRADE","dc:title":"GRADE"},{"@id":"https://cir.nii.ac.jp/all?q=Desensitization,%20Immunologic","dc:title":"Desensitization, Immunologic"},{"@id":"https://cir.nii.ac.jp/all?q=asthma%20exacerbations","dc:title":"asthma exacerbations"},{"@id":"https://cir.nii.ac.jp/all?q=allergen%20immunotherapy,%20allergy,%20asthma,%20asthma%20control,%20asthma%20exacerbations,%20GRADE,%20house%20dust%20mites,%20lung%20function","dc:title":"allergen immunotherapy, allergy, asthma, asthma control, asthma exacerbations, GRADE, house dust mites, lung function"},{"@id":"https://cir.nii.ac.jp/all?q=allergen%20immunotherapy","dc:title":"allergen immunotherapy"},{"@id":"https://cir.nii.ac.jp/all?q=EMC%20OR-01-39-07","dc:title":"EMC OR-01-39-07"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Antigens,%20Dermatophagoides","dc:title":"Antigens, Dermatophagoides"},{"@id":"https://cir.nii.ac.jp/all?q=ResearchInstitutes_Networks_Beacons/lydia_becker_institute_of_immunology_and_inflammation;%20name%3DLydia%20Becker%20Institute","dc:title":"ResearchInstitutes_Networks_Beacons/lydia_becker_institute_of_immunology_and_inflammation; name=Lydia Becker Institute"},{"@id":"https://cir.nii.ac.jp/all?q=house%20dust%20mites","dc:title":"house dust mites"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360294643805197056","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Allergic Rhinitis: What Do We Know About Allergen-Specific Immunotherapy?"}]},{"@id":"https://cir.nii.ac.jp/crid/1360302865549877504","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Circulating T follicular helper 2 cells, T follicular regulatory cells and regulatory B cells are effective biomarkers for predicting the response to house dust mite sublingual immunotherapy in patients with allergic respiratory diseases"}]},{"@id":"https://cir.nii.ac.jp/crid/1360584340527048192","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Clinical characteristics in Japanese patients with chronic rhinosinusitis who underwent endoscopic sinus surgery"}]},{"@id":"https://cir.nii.ac.jp/crid/1390301861421198720","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Allergen immunotherapy in asthma"}]},{"@id":"https://cir.nii.ac.jp/crid/1390565134838930304","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Is environmental adjustment effective in the prevention and treatment of airway allergy?: Cons"},{"@language":"ja","@value":"環境調整は気道アレルギーの予防・治療に有用か？"}]},{"@id":"https://cir.nii.ac.jp/crid/1390856660868720512","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Efficacy of a house dust mite sublingual immunotherapy tablet as add-on dupilumab in asthma with rhinitis"}]},{"@id":"https://cir.nii.ac.jp/crid/1391412326421675904","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Mechanisms of allergen-specific immunotherapy and allergen tolerance"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1111/all.13749"},{"@type":"OPENAIRE","@value":"doi_dedup___::42d4dc3980e11d8e86070af7397d5a0b"},{"@type":"CROSSREF","@value":"10.3388/jspaci.34.138_references_DOI_IWI6Jw97FTxORzutSjFdkJiiUmr"},{"@type":"CROSSREF","@value":"10.3390/pathogens10111406_references_DOI_IWI6Jw97FTxORzutSjFdkJiiUmr"},{"@type":"CROSSREF","@value":"10.3389/falgy.2021.747323_references_DOI_IWI6Jw97FTxORzutSjFdkJiiUmr"},{"@type":"CROSSREF","@value":"10.3389/fimmu.2023.1284205_references_DOI_IWI6Jw97FTxORzutSjFdkJiiUmr"},{"@type":"CROSSREF","@value":"10.1016/j.alit.2022.05.010_references_DOI_IWI6Jw97FTxORzutSjFdkJiiUmr"},{"@type":"CROSSREF","@value":"10.1016/j.alit.2024.05.005_references_DOI_IWI6Jw97FTxORzutSjFdkJiiUmr"},{"@type":"CROSSREF","@value":"10.1016/j.anl.2023.09.007_references_DOI_IWI6Jw97FTxORzutSjFdkJiiUmr"},{"@type":"CROSSREF","@value":"10.1016/j.alit.2020.08.002_references_DOI_IWI6Jw97FTxORzutSjFdkJiiUmr"}]}