{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362262943567088128.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.4049/jimmunol.168.3.1484"}},{"identifier":{"@type":"URI","@value":"https://academic.oup.com/jimmunol/article-pdf/168/3/1484/62548066/1484.pdf"}},{"identifier":{"@type":"PMID","@value":"11801693"}}],"dc:title":[{"@value":"Lack of CD27−CD45RA−Vγ9Vδ2+ T Cell Effectors in Immunocompromised Hosts and During Active Pulmonary Tuberculosis"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title>\n                  <jats:p>In humans, the circulating pool of mycobacteria-reactive Vγ9Vδ2+ T cells is expanded with age and may contribute to Mycobacterium tuberculosis immunosurveillance. We observed that two subsets of Vγ9Vδ2+ T cells could be identified on the basis of CD27 expression in immunocompetent adults, showing that functionally differentiated γδ T cells have lost CD27 expression. In contrast, the CD27−CD45RA−Vγ9Vδ2+ T cell subset of effector cells was absent in cord blood cells from healthy newborns and lacking in the peripheral blood from HIV-infected patients. Moreover, circulating Vγ9Vδ2+ T cell effectors were significantly reduced in patients with acute pulmonary tuberculosis, resulting in a reduced frequency of IFN-γ-producing cells after stimulation with nonpeptidic mycobacterial ligands. These observations indicate that monitoring and boosting γδ T cell effectors could be clinically relevant both in immunocompromised hosts and during active tuberculosis disease.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382262943567088128","@type":"Researcher","foaf:name":[{"@value":"Cristiana Gioia"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Clinical Pathology-Immunopathology, “Padiglione Del Vecchio,” National Institute for Infectious Diseases, “Lazzaro Spallanzani,” Istituto di Ricerca e Cura a Carattere Scientifico , Rome ,"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943567088131","@type":"Researcher","foaf:name":[{"@value":"Chiara Agrati"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Clinical Pathology-Immunopathology, “Padiglione Del Vecchio,” National Institute for Infectious Diseases, “Lazzaro Spallanzani,” Istituto di Ricerca e Cura a Carattere Scientifico , Rome ,"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943567088129","@type":"Researcher","foaf:name":[{"@value":"Rita Casetti"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Clinical Pathology-Immunopathology, “Padiglione Del Vecchio,” National Institute for Infectious Diseases, “Lazzaro Spallanzani,” Istituto di Ricerca e Cura a Carattere Scientifico , Rome ,"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943567088138","@type":"Researcher","foaf:name":[{"@value":"Cristiana Cairo"}],"jpcoar:affiliationName":[{"@value":"Research Center, “San Pietro-Fatebenefratelli” , Rome ,"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943567088130","@type":"Researcher","foaf:name":[{"@value":"Giovanna Borsellino"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Neuroimmunology, “Santa Lucia Foundation,” Istituto di Ricerca e Cura a Carattere Scientifico , Rome ,"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943567088132","@type":"Researcher","foaf:name":[{"@value":"Luca Battistini"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Neuroimmunology, “Santa Lucia Foundation,” Istituto di Ricerca e Cura a Carattere Scientifico , Rome ,"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943567088136","@type":"Researcher","foaf:name":[{"@value":"Giorgio Mancino"}],"jpcoar:affiliationName":[{"@value":"Research Center, “San Pietro-Fatebenefratelli” , Rome ,"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943567088134","@type":"Researcher","foaf:name":[{"@value":"Delia Goletti"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Clinical Pathology-Immunopathology, “Padiglione Del Vecchio,” National Institute for Infectious Diseases, “Lazzaro Spallanzani,” Istituto di Ricerca e Cura a Carattere Scientifico , Rome ,"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943567088133","@type":"Researcher","foaf:name":[{"@value":"Vittorio Colizzi"}],"jpcoar:affiliationName":[{"@value":"Department of Biology, University of Rome, “Tor Vergata” , Rome ,"}]},{"@id":"https://cir.nii.ac.jp/crid/1380307543016916224","@type":"Researcher","foaf:name":[{"@value":"Leopoldo P Pucillo"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Clinical Pathology-Immunopathology, “Padiglione Del Vecchio,” National Institute for Infectious Diseases, “Lazzaro Spallanzani,” Istituto di Ricerca e Cura a Carattere Scientifico , Rome ,"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943567088135","@type":"Researcher","foaf:name":[{"@value":"Fabrizio Poccia"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Clinical Pathology-Immunopathology, “Padiglione Del Vecchio,” National Institute for Infectious Diseases, “Lazzaro Spallanzani,” Istituto di Ricerca e Cura a Carattere Scientifico , Rome ,"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00221767"},{"@type":"EISSN","@value":"15506606"},{"@type":"PISSN","@value":"http://id.crossref.org/issn/00221767"}],"prism:publicationName":[{"@value":"The Journal of Immunology"}],"dc:publisher":[{"@value":"Oxford University Press (OUP)"}],"prism:publicationDate":"2002-02-01","prism:volume":"168","prism:number":"3","prism:startingPage":"1484","prism:endingPage":"1489"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://academic.oup.com/pages/standard-publication-reuse-rights"],"url":[{"@id":"https://academic.oup.com/jimmunol/article-pdf/168/3/1484/62548066/1484.pdf"}],"createdAt":"2014-04-20","modifiedAt":"2026-02-02","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Adult","dc:title":"Adult"},{"@id":"https://cir.nii.ac.jp/all?q=Infant,%20Newborn","dc:title":"Infant, Newborn"},{"@id":"https://cir.nii.ac.jp/all?q=HIV%20Infections","dc:title":"HIV Infections"},{"@id":"https://cir.nii.ac.jp/all?q=Receptors,%20Antigen,%20T-Cell,%20gamma-delta","dc:title":"Receptors, Antigen, T-Cell, gamma-delta"},{"@id":"https://cir.nii.ac.jp/all?q=Fetal%20Blood","dc:title":"Fetal Blood"},{"@id":"https://cir.nii.ac.jp/all?q=Immunophenotyping","dc:title":"Immunophenotyping"},{"@id":"https://cir.nii.ac.jp/all?q=Tumor%20Necrosis%20Factor%20Receptor%20Superfamily,%20Member%207","dc:title":"Tumor Necrosis Factor Receptor Superfamily, Member 7"},{"@id":"https://cir.nii.ac.jp/all?q=Immunocompromised%20Host","dc:title":"Immunocompromised Host"},{"@id":"https://cir.nii.ac.jp/all?q=Interferon-gamma","dc:title":"Interferon-gamma"},{"@id":"https://cir.nii.ac.jp/all?q=T-Lymphocyte%20Subsets","dc:title":"T-Lymphocyte Subsets"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Leukocyte%20Common%20Antigens","dc:title":"Leukocyte Common Antigens"},{"@id":"https://cir.nii.ac.jp/all?q=Immunologic%20Memory","dc:title":"Immunologic Memory"},{"@id":"https://cir.nii.ac.jp/all?q=Interphase","dc:title":"Interphase"},{"@id":"https://cir.nii.ac.jp/all?q=Tuberculosis,%20Pulmonary","dc:title":"Tuberculosis, Pulmonary"},{"@id":"https://cir.nii.ac.jp/all?q=Cells,%20Cultured","dc:title":"Cells, Cultured"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360567185487190144","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"V<i>γ</i>2V<i>δ</i>2 T‐cell co‐stimulation increases natural killer cell killing of monocyte‐derived dendritic cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679877865216","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Orally administrated risedronate can commit V.GAMMA.2V.DELTA.2 T cells to IFN-.GAMMA. secreting effectors in patients with 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