{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362262943568796032.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.tetlet.2004.02.082"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0040403904004071?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0040403904004071?httpAccept=text/plain"}}],"dc:title":[{"@value":"General and practical catalytic enantioselective Strecker reaction of ketoimines: significant improvement through catalyst tuning by protic additives"}],"description":[{"notation":[{"@value":"Abstract   Significant improvement in enantioselectivity and catalyst activity was achieved for the catalytic enantioselective Strecker reaction. Using a catalyst (1–2.5 mol %) prepared from Gd(O  i  Pr) 3  and  d -glucose derived ligand   1  , and in the presence of 2,6-dimethylphenol as an additive, high enantioselectivity was obtained from a wide range of ketoimines, including heteroaromatic and cyclic ketoimines. The new method was applied to an efficient catalytic asymmetric synthesis of sorbinil, a therapeutic agent for diabetic complications."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382262943568796032","@type":"Researcher","foaf:name":[{"@value":"Nobuki Kato"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943568796033","@type":"Researcher","foaf:name":[{"@value":"Masato Suzuki"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943568796035","@type":"Researcher","foaf:name":[{"@value":"Motomu Kanai"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943568796034","@type":"Researcher","foaf:name":[{"@value":"Masakatsu Shibasaki"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00404039"}],"prism:publicationName":[{"@value":"Tetrahedron Letters"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2004-04","prism:volume":"45","prism:number":"15","prism:startingPage":"3147","prism:endingPage":"3151"},"reviewed":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","https://www.elsevier.com/legal/tdmrep-license"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S0040403904004071?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S0040403904004071?httpAccept=text/plain"}],"createdAt":"2004-03-06","modifiedAt":"2025-09-22","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050573792601759616","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Construction of chiral α-tert-amine scaffolds via amine-catalyzed asymmetric Mannich reactions of alkyl-substituted ketimines"},{"@value":"Construction of chiral α-<i>tert</i>-amine scaffolds <i>via</i> amine-catalyzed asymmetric Mannich reactions of alkyl-substituted ketimines"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285708226862848","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Chiral Lanthanum(III)-Binaphthyldisulfonate Complexes for Catalytic Enantioselective Strecker Reaction"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567179878785536","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Asymmetric Synthesis of Less Accessible α‐Tertiary Amines from Alkynyl <i>Z‐</i>Ketimines"}]},{"@id":"https://cir.nii.ac.jp/crid/1360576118821105024","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Catalytic Asymmetric Strecker Reaction of Ketoimines with Potassium Cyanide"}]},{"@id":"https://cir.nii.ac.jp/crid/2051714791998240896","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Recent advances in catalytic asymmetric C-C bond-forming reactions to ketimines promoted by metal-based catalysts"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1016/j.tetlet.2004.02.082"},{"@type":"OPENAIRE","@value":"doi_dedup___::60e1ad116be5eb52f8b0330139c702b6"},{"@type":"CROSSREF","@value":"10.1039/d0sc05269h_references_DOI_AvlbH5u7Hex3cW1A2EC6bqFXr9u"},{"@type":"CROSSREF","@value":"10.1002/anie.201710084_references_DOI_AvlbH5u7Hex3cW1A2EC6bqFXr9u"},{"@type":"CROSSREF","@value":"10.1246/bcsj.20140302_references_DOI_AvlbH5u7Hex3cW1A2EC6bqFXr9u"},{"@type":"CROSSREF","@value":"10.1002/ajoc.202100608_references_DOI_AvlbH5u7Hex3cW1A2EC6bqFXr9u"},{"@type":"CROSSREF","@value":"10.1021/ol900680f_references_DOI_AvlbH5u7Hex3cW1A2EC6bqFXr9u"}]}