{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362262943576231808.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.3390/biom5020808"}},{"identifier":{"@type":"URI","@value":"https://www.mdpi.com/2218-273X/5/2/808/pdf"}}],"dc:title":[{"@value":"Oxidative Stress and the Homeodynamics of Iron Metabolism"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Iron and oxygen share a delicate partnership since both are indispensable for survival, but if the partnership becomes inadequate, this may rapidly terminate life. Virtually all cell components are directly or indirectly affected by cellular iron metabolism, which represents a complex, redox-based machinery that is controlled by, and essential to, metabolic requirements. Under conditions of increased oxidative stress—i.e., enhanced formation of reactive oxygen species (ROS)—however, this machinery may turn into a potential threat, the continued requirement for iron promoting adverse reactions such as the iron/H2O2-based formation of hydroxyl radicals, which exacerbate the initial pro-oxidant condition. This review will discuss the multifaceted homeodynamics of cellular iron management under normal conditions as well as in the context of oxidative stress.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382262943576231809","@type":"Researcher","foaf:name":[{"@value":"Nikolaus Bresgen"}],"jpcoar:affiliationName":[{"@value":"Department of Cell Biology, University of Salzburg, Hellbrunnerstrasse 34, 5020 Salzburg, Austria"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943576231808","@type":"Researcher","foaf:name":[{"@value":"Peter Eckl"}],"jpcoar:affiliationName":[{"@value":"Department of Cell Biology, University of Salzburg, Hellbrunnerstrasse 34, 5020 Salzburg, Austria"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"2218273X"}],"prism:publicationName":[{"@value":"Biomolecules"}],"dc:publisher":[{"@value":"MDPI AG"}],"prism:publicationDate":"2015-05-11","prism:volume":"5","prism:number":"2","prism:startingPage":"808","prism:endingPage":"847"},"reviewed":"false","dc:rights":["https://creativecommons.org/licenses/by/4.0/"],"url":[{"@id":"https://www.mdpi.com/2218-273X/5/2/808/pdf"}],"createdAt":"2015-05-11","modifiedAt":"2025-10-11","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360009142685986688","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"NRF2 pathway activation by KEAP1 inhibition attenuates the manifestation of aging phenotypes in salivary glands"}]},{"@id":"https://cir.nii.ac.jp/crid/1360570166571760384","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Air pollution and children’s health—a review of adverse effects associated with prenatal exposure from fine to ultrafine particulate matter"}]},{"@id":"https://cir.nii.ac.jp/crid/1360849941519486080","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"How iron is handled in the course of heme catabolism: Integration of heme oxygenase with intracellular iron transport mechanisms mediated by poly (rC)-binding protein-2"}]},{"@id":"https://cir.nii.ac.jp/crid/1390007050485785728","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Immunohistochemical Study of Mitochondrial Ferritin in the Midbrain of Patients with Progressive Supranuclear Palsy"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.3390/biom5020808"},{"@type":"CROSSREF","@value":"10.1016/j.redox.2020.101603_references_DOI_6ZYCcbhQVkHusFe3zyYtDT1qWqS"},{"@type":"CROSSREF","@value":"10.1267/ahc.21-00019_references_DOI_6ZYCcbhQVkHusFe3zyYtDT1qWqS"},{"@type":"CROSSREF","@value":"10.1186/s12199-021-00995-5_references_DOI_6ZYCcbhQVkHusFe3zyYtDT1qWqS"},{"@type":"CROSSREF","@value":"10.1016/j.abb.2019.108071_references_DOI_6ZYCcbhQVkHusFe3zyYtDT1qWqS"}]}