{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362262943666209792.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.3233/jae-2002-403"}},{"identifier":{"@type":"URI","@value":"https://journals.sagepub.com/doi/pdf/10.3233/JAE-2002-403"}}],"dc:title":[{"@value":"Effect of magnetic field on nitric oxide synthesis of cultured endothelial cells"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p> The effect of magnetic field on nitric oxide (NO) production of cultured human umbilical vein endothelial cells (HUVECs) was investigated. Static magnetic fields (30 mT, 300 mT) and an oscillating magnetic field (30 mT, 20 Hz) were applied to HUVECs for 0.5, 1 and 6 hours and intracellular NO was observed using a fluorescent indicator. There was no effect of the static magnetic field on the NO production of the HUVECs. In contrast, the NO production increased with applying the oscillating magnetic field for 0.5 hour. However, such an increase of NO production was not observed for 1 and 6 hours. We performed a separate experiment to clarify the mechanism of NO synthesis by using an inhibitor of calcium-independent activation of NO synthase. The inhibitor suppressed the increase of NO production caused by the oscillating magnetic field. It can be concluded that oscillating magnetic field may activate calcium-independent pathway of activation for NO synthase. </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382262943666209793","@type":"Researcher","foaf:name":[{"@value":"Naoya Sakamoto"}],"jpcoar:affiliationName":[{"@value":"Graduate School of Mechanical Engineering, Tohoku University, Aramaki-Aoba 01, Sendai 980-8579, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943666209664","@type":"Researcher","foaf:name":[{"@value":"Toshiro Ohashi"}],"jpcoar:affiliationName":[{"@value":"Graduate School of Mechanical Engineering, Tohoku University, Aramaki-Aoba 01, Sendai 980-8579, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943666209792","@type":"Researcher","foaf:name":[{"@value":"Masaaki Sato"}],"jpcoar:affiliationName":[{"@value":"Graduate School of Mechanical Engineering, Tohoku University, Aramaki-Aoba 01, Sendai 980-8579, Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"13835416"},{"@type":"EISSN","@value":"18758800"}],"prism:publicationName":[{"@value":"International Journal of Applied Electromagnetics and Mechanics"}],"dc:publisher":[{"@value":"SAGE Publications"}],"prism:publicationDate":"2001-05","prism:volume":"14","prism:number":"1-4","prism:startingPage":"317","prism:endingPage":"322"},"reviewed":"false","dc:rights":["https://journals.sagepub.com/page/policies/text-and-data-mining-license"],"url":[{"@id":"https://journals.sagepub.com/doi/pdf/10.3233/JAE-2002-403"}],"createdAt":"2018-12-21","modifiedAt":"2025-03-11","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360002215823020800","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Role of paxillin in the early phase of orientation of the vascular endothelial cells exposed to cyclic stretching"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283692436915200","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The effect of a 50-Hz sinusoidal magnetic field on nitric oxide (NO) production by human umbilical vein endothelial cells (HUVECs)"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567181475783680","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Effect of Initial Orientation of Vascular Endothelial Cells on Activation of RhoGTPases Induced by Fluid Shear Stress"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567181953431424","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Direct measurement of shear strain in adherent vascular endothelial cells exposed to fluid shear stress"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846640372853376","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Morphological Responses of Vascular Endothelial Cells Induced by Local Stretch Transmitted Through Intercellular Junctions"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.3233/jae-2002-403"},{"@type":"OPENAIRE","@value":"doi_dedup___::c19c91abb44707f5844097267e4f6163"},{"@type":"CROSSREF","@value":"10.1016/j.bbrc.2010.02.115_references_DOI_6UJDpyJJ6bBUpoZEjMa1J594VFF"},{"@type":"CROSSREF","@value":"10.1088/1742-6596/344/1/012006_references_DOI_6UJDpyJJ6bBUpoZEjMa1J594VFF"},{"@type":"CROSSREF","@value":"10.1007/s12195-011-0173-z_references_DOI_6UJDpyJJ6bBUpoZEjMa1J594VFF"},{"@type":"CROSSREF","@value":"10.1007/s11340-008-9143-3_references_DOI_6UJDpyJJ6bBUpoZEjMa1J594VFF"},{"@type":"CROSSREF","@value":"10.1016/j.bbrc.2012.01.083_references_DOI_6UJDpyJJ6bBUpoZEjMa1J594VFF"}]}