{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362262943674628736.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1183/13993003.00547-2020"}},{"identifier":{"@type":"URI","@value":"https://syndication.highwire.org/content/doi/10.1183/13993003.00547-2020"}}],"dc:title":[{"@value":"Comorbidity and its impact on 1590 patients with COVID-19 in China: a nationwide analysis"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:sec>\n                    <jats:title>Background</jats:title>\n                    <jats:p>The coronavirus disease 2019 (COVID-19) outbreak is evolving rapidly worldwide.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective</jats:title>\n                    <jats:p>To evaluate the risk of serious adverse outcomes in patients with COVID-19 by stratifying the comorbidity status.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods</jats:title>\n                    <jats:p>We analysed data from 1590 laboratory confirmed hospitalised patients from 575 hospitals in 31 provinces/autonomous regions/provincial municipalities across mainland China between 11 December 2019 and 31 January 2020. We analysed the composite end-points, which consisted of admission to an intensive care unit, invasive ventilation or death. The risk of reaching the composite end-points was compared according to the presence and number of comorbidities.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Results</jats:title>\n                    <jats:p>The mean age was 48.9 years and 686 (42.7%) patients were female. Severe cases accounted for 16.0% of the study population. 131 (8.2%) patients reached the composite end-points. 399 (25.1%) reported having at least one comorbidity. The most prevalent comorbidity was hypertension (16.9%), followed by diabetes (8.2%). 130 (8.2%) patients reported having two or more comorbidities. After adjusting for age and smoking status, COPD (HR (95% CI) 2.681 (1.424–5.048)), diabetes (1.59 (1.03–2.45)), hypertension (1.58 (1.07–2.32)) and malignancy (3.50 (1.60–7.64)) were risk factors of reaching the composite end-points. The hazard ratio (95% CI) was 1.79 (1.16–2.77) among patients with at least one comorbidity and 2.59 (1.61–4.17) among patients with two or more comorbidities.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion</jats:title>\n                    <jats:p>Among laboratory confirmed cases of COVID-19, patients with any comorbidity yielded poorer clinical outcomes than those without. A greater number of comorbidities also correlated with poorer clinical outcomes.</jats:p>\n                  </jats:sec>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382262943674628736","@type":"Researcher","foaf:name":[{"@value":"Wei-jie Guan"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943674628879","@type":"Researcher","foaf:name":[{"@value":"Wen-hua Liang"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943674628995","@type":"Researcher","foaf:name":[{"@value":"Yi Zhao"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943674628872","@type":"Researcher","foaf:name":[{"@value":"Heng-rui Liang"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943674628887","@type":"Researcher","foaf:name":[{"@value":"Zi-sheng Chen"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943674628882","@type":"Researcher","foaf:name":[{"@value":"Yi-min Li"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943674628883","@type":"Researcher","foaf:name":[{"@value":"Xiao-qing Liu"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943674628742","@type":"Researcher","foaf:name":[{"@value":"Ru-chong Chen"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943674628876","@type":"Researcher","foaf:name":[{"@value":"Chun-li Tang"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943674628994","@type":"Researcher","foaf:name":[{"@value":"Tao Wang"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943674628747","@type":"Researcher","foaf:name":[{"@value":"Chun-quan Ou"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943674628865","@type":"Researcher","foaf:name":[{"@value":"Li Li"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943674628864","@type":"Researcher","foaf:name":[{"@value":"Ping-yan Chen"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943674628744","@type":"Researcher","foaf:name":[{"@value":"Ling Sang"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943674628873","@type":"Researcher","foaf:name":[{"@value":"Wei Wang"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943674628745","@type":"Researcher","foaf:name":[{"@value":"Jian-fu Li"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943674628998","@type":"Researcher","foaf:name":[{"@value":"Cai-chen Li"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943674628739","@type":"Researcher","foaf:name":[{"@value":"Li-min Ou"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943674628748","@type":"Researcher","foaf:name":[{"@value":"Bo Cheng"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943674628884","@type":"Researcher","foaf:name":[{"@value":"Shan Xiong"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943674628996","@type":"Researcher","foaf:name":[{"@value":"Zheng-yi Ni"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943674628870","@type":"Researcher","foaf:name":[{"@value":"Jie Xiang"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943674628880","@type":"Researcher","foaf:name":[{"@value":"Yu Hu"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943674628992","@type":"Researcher","foaf:name":[{"@value":"Lei Liu"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943674628743","@type":"Researcher","foaf:name":[{"@value":"Hong Shan"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943674628737","@type":"Researcher","foaf:name":[{"@value":"Chun-liang Lei"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943674628881","@type":"Researcher","foaf:name":[{"@value":"Yi-xiang Peng"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943674628886","@type":"Researcher","foaf:name":[{"@value":"Li Wei"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943674629001","@type":"Researcher","foaf:name":[{"@value":"Yong Liu"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943674628871","@type":"Researcher","foaf:name":[{"@value":"Ya-hua Hu"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943674628866","@type":"Researcher","foaf:name":[{"@value":"Peng Peng"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943674628874","@type":"Researcher","foaf:name":[{"@value":"Jian-ming Wang"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943674628740","@type":"Researcher","foaf:name":[{"@value":"Ji-yang Liu"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943674628999","@type":"Researcher","foaf:name":[{"@value":"Zhong Chen"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943674628877","@type":"Researcher","foaf:name":[{"@value":"Gang Li"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943674628741","@type":"Researcher","foaf:name":[{"@value":"Zhi-jian Zheng"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943674628867","@type":"Researcher","foaf:name":[{"@value":"Shao-qin Qiu"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943674628885","@type":"Researcher","foaf:name":[{"@value":"Jie Luo"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943674628997","@type":"Researcher","foaf:name":[{"@value":"Chang-jiang 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He"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"09031936"},{"@type":"EISSN","@value":"13993003"}],"prism:publicationName":[{"@value":"European Respiratory Journal"}],"dc:publisher":[{"@value":"European Respiratory Society (ERS)"}],"prism:publicationDate":"2020-03-26","prism:volume":"55","prism:number":"5","prism:startingPage":"2000547"},"reviewed":"false","dc:rights":["http://creativecommons.org/licenses/by-nc/4.0/"],"url":[{"@id":"https://syndication.highwire.org/content/doi/10.1183/13993003.00547-2020"}],"createdAt":"2020-03-26","modifiedAt":"2025-02-24","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360022304973695360","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"e-Learning and Web-Based Tools for Psychosocial Interventions Addressing Neuropsychiatric Symptoms of Dementia During the COVID-19 Pandemic in Tokyo, Japan: Quasi-Experimental Study 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