{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362262943783561600.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1155/2014/249856"}},{"identifier":{"@type":"URI","@value":"http://downloads.hindawi.com/journals/bmri/2014/249856.pdf"}},{"identifier":{"@type":"URI","@value":"http://downloads.hindawi.com/journals/bmri/2014/249856.xml"}}],"dc:title":[{"@value":"Worldwide Dissemination of the NDM-Type Carbapenemases in Gram-Negative Bacteria"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>The emergence of one of the most recently described carbapenemases, namely, the New Delhi metallo-lactamase (NDM-1), constitutes a critical and growingly important medical issue. This resistance trait compromises the efficacy of almost all lactams (except aztreonam), including the last resort carbapenems. Therapeutical options may remain limited mostly to colistin, tigecycline, and fosfomycin. The main known reservoir of NDM producers is the Indian subcontinent whereas a secondary reservoir seems to have established the Balkans regions and the Middle East. Although the spread of<mml:math xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" id=\"M1\"><mml:mi>b</mml:mi><mml:mi>l</mml:mi><mml:msub><mml:mrow><mml:mi>a</mml:mi></mml:mrow><mml:mrow><mml:mtext>NDM</mml:mtext></mml:mrow></mml:msub></mml:math>-like genes (several variants) is derived mostly by conjugative plasmids in Enterobacteriaceae, this carbapenemase has also been identified in<jats:italic>P. aeruginosa</jats:italic>and<jats:italic>Acinetobacter</jats:italic>spp.<jats:italic>Acinetobacter</jats:italic>sp. may play a pivotal role for spreading<mml:math xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" id=\"M2\"><mml:mi>b</mml:mi><mml:mi>l</mml:mi><mml:msub><mml:mrow><mml:mi>a</mml:mi></mml:mrow><mml:mrow><mml:mtext>NDM</mml:mtext></mml:mrow></mml:msub></mml:math>genes for its natural reservoir to Enterobacteriaceae. Rapid diagnostic techniques (Carba NP test) and screening of carriers are the cornerstone to try to contain this outbreak which threatens the efficacy of the modern medicine.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382262943783561600","@type":"Researcher","foaf:name":[{"@value":"Laurent Dortet"}],"jpcoar:affiliationName":[{"@value":"INSERM U914 “Emerging Resistance to Antibiotics”, 78 Avenue du Général Leclerc, 94270 Le Kremlin-Bicêtre, France"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943783561601","@type":"Researcher","foaf:name":[{"@value":"Laurent Poirel"}],"jpcoar:affiliationName":[{"@value":"INSERM U914 “Emerging Resistance to Antibiotics”, 78 Avenue du Général Leclerc, 94270 Le Kremlin-Bicêtre, France"},{"@value":"Medical and Molecular Microbiology Unit, Department of Medicine, Faculty of Science, University of Fribourg, 3 Rue Albert Gockel, 1700 Fribourg, Switzerland"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943783561472","@type":"Researcher","foaf:name":[{"@value":"Patrice Nordmann"}],"jpcoar:affiliationName":[{"@value":"INSERM U914 “Emerging Resistance to Antibiotics”, 78 Avenue du Général Leclerc, 94270 Le Kremlin-Bicêtre, France"},{"@value":"Medical and Molecular Microbiology Unit, Department of Medicine, Faculty of Science, University of Fribourg, 3 Rue Albert Gockel, 1700 Fribourg, Switzerland"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"23146133"},{"@type":"EISSN","@value":"23146141"}],"prism:publicationName":[{"@value":"BioMed Research International"}],"dc:publisher":[{"@value":"Hindawi Limited"}],"prism:publicationDate":"2014","prism:volume":"2014","prism:startingPage":"1","prism:endingPage":"12"},"reviewed":"false","dc:rights":["http://creativecommons.org/licenses/by/3.0/"],"url":[{"@id":"http://downloads.hindawi.com/journals/bmri/2014/249856.pdf"},{"@id":"http://downloads.hindawi.com/journals/bmri/2014/249856.xml"}],"createdAt":"2014-03-26","modifiedAt":"2022-03-31","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004234481869184","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Prevalence and Molecular Epidemiology of Clinical Isolates of\n                    <i>Escherichia coli</i>\n                    and\n                    <i>Klebsiella pneumoniae</i>\n                    Harboring Extended-Spectrum Beta-Lactamase and Carbapenemase Genes in Bangladesh"}]},{"@id":"https://cir.nii.ac.jp/crid/1360005520973997568","@type":"Article","resourceType":"学術雑誌論文(journal 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article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Prevalence of Extended-Spectrum Beta-Lactamase and Carbapenemase Genes in Clinical Isolates of\n                    <i>Escherichia coli</i>\n                    in Myanmar: Dominance of\n                    <i>bla</i>\n                    <sub>NDM-5</sub>\n                    and Emergence of\n                    <i>bla</i>\n                    <sub>OXA-181</sub>"}]},{"@id":"https://cir.nii.ac.jp/crid/1360861705581841408","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"A Nationwide Plasmidome Surveillance in Thailand Reveals a Limited Variety of New Delhi Metallo-β-Lactamase-Producing Carbapenem-Resistant\n            <i>Enterobacteriaceae</i>\n            Clones and Spreading Plasmids"}]},{"@id":"https://cir.nii.ac.jp/crid/1361412896755350144","@type":"Article","resourceType":"学術雑誌論文(journal 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a Hospital Sink"},{"@value":"Occurrence of bla[NDM-1] in a Clinical Isolate of Acinetobacter lwoffii in Japan : Comparison of bla[NDM-1]-Harboring Plasmids between A. lwoffii and A. pittii Originated from a Hospital 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