{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362262943805563648.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1080/10641960902977908"}},{"identifier":{"@type":"URI","@value":"http://www.tandfonline.com/doi/pdf/10.1080/10641960902977908"}},{"identifier":{"@type":"PMID","@value":"19811362"}}],"dc:title":[{"@value":"Anti-Hypertensive Effect of γ-Aminobutyric Acid (GABA)-Rich<i>Chlorella</i>on High-Normal Blood Pressure and Borderline Hypertension in Placebo-Controlled Double Blind Study"}],"description":[{"notation":[{"@value":"The anti-hypertensive effect of GABA-rich Chlorella was studied after oral administration for 12 weeks in the subjects with high-normal blood pressure and borderline hypertension in the placebo-controlled, double-blind manner in order to investigate if GABA-rich Chlorella, a dietary supplement, is useful in control of blood pressure. Eighty subjects with Systolic blood pressure (SBP) 130-159 mmHg or diastolic blood pressure (DBP) 85-99 mmHg (40 subjects/group) took the blinded substance of GABA-rich Chlorella (20 mg as gamma-aminobutyric acid) or placebo twice daily for 12 weeks, and had follow-up observation for an additional 4 weeks. Systolic blood pressure in the subjects given GABA-rich Chlorella significantly decreased compared with placebo (p0.01). Diastolic blood pressure had the tendency to decrease after intake of GABA-rich Chlorella. Neither adverse events nor abnormal laboratory findings were reported throughout the study period. Reduction of SBP in the subjects with borderline hypertension was higher than those in the subjects with high-normal blood pressure. These results suggest that GABA-rich Chlorella significantly decreased high-normal blood pressure and borderline hypertension, and is a beneficial dietary supplement for prevention of the development of hypertension."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382262943805563652","@type":"Researcher","foaf:name":[{"@value":"Morio Shimada"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943805563648","@type":"Researcher","foaf:name":[{"@value":"Takashi Hasegawa"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943805563649","@type":"Researcher","foaf:name":[{"@value":"Chiaki Nishimura"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943805563654","@type":"Researcher","foaf:name":[{"@value":"Hiroko Kan"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943805563650","@type":"Researcher","foaf:name":[{"@value":"Toshihiro Kanno"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943805563651","@type":"Researcher","foaf:name":[{"@value":"Toshio Nakamura"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943805563653","@type":"Researcher","foaf:name":[{"@value":"Tsuneo Matsubayashi"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"10641963"},{"@type":"EISSN","@value":"15256006"}],"prism:publicationName":[{"@value":"Clinical and Experimental Hypertension"}],"dc:publisher":[{"@value":"Informa UK Limited"}],"prism:publicationDate":"2009-01","prism:volume":"31","prism:number":"4","prism:startingPage":"342","prism:endingPage":"354"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"http://www.tandfonline.com/doi/pdf/10.1080/10641960902977908"}],"createdAt":"2009-08-13","modifiedAt":"2025-02-11","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Adult","dc:title":"Adult"},{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Dose-Response%20Relationship,%20Drug","dc:title":"Dose-Response Relationship, Drug"},{"@id":"https://cir.nii.ac.jp/all?q=Plant%20Extracts","dc:title":"Plant Extracts"},{"@id":"https://cir.nii.ac.jp/all?q=Blood%20Pressure","dc:title":"Blood Pressure"},{"@id":"https://cir.nii.ac.jp/all?q=Chlorella","dc:title":"Chlorella"},{"@id":"https://cir.nii.ac.jp/all?q=Middle%20Aged","dc:title":"Middle Aged"},{"@id":"https://cir.nii.ac.jp/all?q=Body%20Mass%20Index","dc:title":"Body Mass Index"},{"@id":"https://cir.nii.ac.jp/all?q=Treatment%20Outcome","dc:title":"Treatment Outcome"},{"@id":"https://cir.nii.ac.jp/all?q=Double-Blind%20Method","dc:title":"Double-Blind Method"},{"@id":"https://cir.nii.ac.jp/all?q=Heart%20Rate","dc:title":"Heart Rate"},{"@id":"https://cir.nii.ac.jp/all?q=Hypertension","dc:title":"Hypertension"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Female","dc:title":"Female"},{"@id":"https://cir.nii.ac.jp/all?q=Antihypertensive%20Agents","dc:title":"Antihypertensive Agents"},{"@id":"https://cir.nii.ac.jp/all?q=gamma-Aminobutyric%20Acid","dc:title":"gamma-Aminobutyric Acid"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360869856056371840","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Is hepatic GABA transaminase a promising target for obesity and epilepsy treatments?"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282681301929600","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Effects of Intake of Pickles Containing <i>Lactobacillus brevis</i> on Immune Activity and Bowel Symptoms in Female Students"},{"@value":"Effects of Intake of Pickles Containing Lactobacillus brevis on Immune Activity and Bowel Symptoms in Female Students"}]},{"@id":"https://cir.nii.ac.jp/crid/1390295259244732672","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Chlorella improves inflammatory profiles and quality of life of prediabetes and diabetes patients"}]},{"@id":"https://cir.nii.ac.jp/crid/1390305278750819968","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"九州産モリンガの機能性と活用"},{"@language":"en","@value":"Functionality and Use of Kyushu Moringa"},{"@language":"ja-Kana","@value":"キュウシュウサン モリンガ ノ キノウセイ ト カツヨウ"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1080/10641960902977908"},{"@type":"OPENAIRE","@value":"doi_dedup___::d166bac3aac5814026ac988e3889ac81"},{"@type":"CROSSREF","@value":"10.3177/jnsv.59.402_references_DOI_8estLXMOhGktTQ4a7GnjgEHx9D9"},{"@type":"CROSSREF","@value":"10.4327/jsnfs.78.221_references_DOI_8estLXMOhGktTQ4a7GnjgEHx9D9"},{"@type":"CROSSREF","@value":"10.2131/fts.10.31_references_DOI_8estLXMOhGktTQ4a7GnjgEHx9D9"},{"@type":"CROSSREF","@value":"10.1093/bbb/zbae066_references_DOI_8estLXMOhGktTQ4a7GnjgEHx9D9"}]}