{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362262943841144320.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1126/science.1164440"}},{"identifier":{"@type":"URI","@value":"https://www.science.org/doi/pdf/10.1126/science.1164440"}},{"identifier":{"@type":"PMID","@value":"18927357"}}],"dc:title":[{"@value":"Structure and Molecular Mechanism of a Nucleobase–Cation–Symport-1 Family Transporter"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>\n                    The nucleobase–cation–symport-1 (NCS1) transporters are essential components of salvage pathways for nucleobases and related metabolites. Here, we report the 2.85-angstrom resolution structure of the NCS1 benzyl-hydantoin transporter, Mhp1, from\n                    <jats:italic>Microbacterium liquefaciens.</jats:italic>\n                    Mhp1 contains 12 transmembrane helices, 10 of which are arranged in two inverted repeats of five helices. The structures of the outward-facing open and substrate-bound occluded conformations were solved, showing how the outward-facing cavity closes upon binding of substrate. Comparisons with the leucine transporter LeuT\n                    <jats:sub>Aa</jats:sub>\n                    and the galactose transporter vSGLT reveal that the outward- and inward-facing cavities are symmetrically arranged on opposite sides of the membrane. The reciprocal opening and closing of these cavities is synchronized by the inverted repeat helices 3 and 8, providing the structural basis of the alternating access model for membrane transport.\n                  </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382262943841144197","@type":"Researcher","foaf:name":[{"@value":"Simone Weyand"}],"jpcoar:affiliationName":[{"@value":"Membrane Protein Laboratory, Diamond Light Source Limited, Harwell Science and Innovation Campus, Chilton, Didcot, Oxfordshire OX11 0DE, UK."},{"@value":"Division of Molecular Biosciences, Membrane Protein Crystallography Group, Imperial College, London SW7 2AZ, UK."},{"@value":"Human Receptor Crystallography Project, Exploratory Research for Advanced Technology (ERATO), Japan Science and Technology Agency, Yoshidakonoe-cho, Sakyo-ku, Kyoto 606-8501, Japan."},{"@value":"Department of Cell Biology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe, Sakyo-Ku, Kyoto 606-8501, Japan."},{"@value":"Astbury Centre for Structural Molecular Biology, Institute for Membrane and Systems Biology, University of Leeds, Leeds LS2 9JT, UK."}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943841144324","@type":"Researcher","foaf:name":[{"@value":"Tatsuro Shimamura"}],"jpcoar:affiliationName":[{"@value":"Membrane Protein Laboratory, Diamond Light Source Limited, Harwell Science and Innovation Campus, Chilton, Didcot, Oxfordshire OX11 0DE, UK."},{"@value":"Division of Molecular Biosciences, Membrane Protein Crystallography Group, Imperial College, London SW7 2AZ, UK."},{"@value":"Human Receptor Crystallography Project, Exploratory Research for Advanced Technology (ERATO), Japan Science and Technology Agency, Yoshidakonoe-cho, Sakyo-ku, Kyoto 606-8501, Japan."},{"@value":"Department of Cell Biology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe, Sakyo-Ku, Kyoto 606-8501, Japan."},{"@value":"Astbury Centre for Structural Molecular Biology, Institute for Membrane and Systems Biology, University of Leeds, Leeds LS2 9JT, UK."}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943841144195","@type":"Researcher","foaf:name":[{"@value":"Shunsuke Yajima"}],"jpcoar:affiliationName":[{"@value":"Membrane Protein Laboratory, Diamond Light Source Limited, Harwell Science and Innovation Campus, Chilton, Didcot, Oxfordshire OX11 0DE, UK."},{"@value":"Division of Molecular Biosciences, Membrane Protein Crystallography Group, Imperial College, London SW7 2AZ, UK."},{"@value":"Human Receptor Crystallography Project, Exploratory Research for Advanced Technology (ERATO), Japan Science and Technology Agency, Yoshidakonoe-cho, Sakyo-ku, Kyoto 606-8501, Japan."},{"@value":"Department of Cell Biology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe, Sakyo-Ku, Kyoto 606-8501, Japan."},{"@value":"Astbury Centre for Structural Molecular Biology, Institute for Membrane and Systems Biology, University of Leeds, Leeds LS2 9JT, UK."}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943841144325","@type":"Researcher","foaf:name":[{"@value":"Shun'ichi Suzuki"}],"jpcoar:affiliationName":[{"@value":"Membrane Protein Laboratory, Diamond Light Source Limited, Harwell Science and Innovation Campus, Chilton, Didcot, Oxfordshire OX11 0DE, UK."},{"@value":"Division of Molecular Biosciences, Membrane Protein Crystallography Group, Imperial College, London SW7 2AZ, UK."},{"@value":"Human Receptor Crystallography Project, Exploratory Research for Advanced Technology (ERATO), Japan Science and Technology Agency, Yoshidakonoe-cho, Sakyo-ku, Kyoto 606-8501, Japan."},{"@value":"Department of Cell Biology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe, Sakyo-Ku, Kyoto 606-8501, Japan."},{"@value":"Astbury Centre for Structural Molecular Biology, Institute for Membrane and Systems Biology, University of Leeds, Leeds LS2 9JT, UK."}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943841144322","@type":"Researcher","foaf:name":[{"@value":"Osman Mirza"}],"jpcoar:affiliationName":[{"@value":"Membrane Protein Laboratory, Diamond Light Source Limited, Harwell Science and Innovation Campus, Chilton, Didcot, Oxfordshire OX11 0DE, UK."},{"@value":"Division of Molecular Biosciences, Membrane Protein Crystallography Group, Imperial College, London SW7 2AZ, UK."},{"@value":"Human Receptor Crystallography Project, Exploratory Research for Advanced Technology (ERATO), Japan Science and Technology Agency, Yoshidakonoe-cho, Sakyo-ku, Kyoto 606-8501, Japan."},{"@value":"Department of Cell Biology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe, Sakyo-Ku, Kyoto 606-8501, Japan."},{"@value":"Astbury Centre for Structural Molecular Biology, Institute for Membrane and Systems Biology, University of Leeds, Leeds LS2 9JT, UK."}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943841144199","@type":"Researcher","foaf:name":[{"@value":"Kuakarun Krusong"}],"jpcoar:affiliationName":[{"@value":"Membrane Protein Laboratory, Diamond Light Source Limited, Harwell Science and Innovation Campus, Chilton, Didcot, Oxfordshire OX11 0DE, UK."},{"@value":"Division of Molecular Biosciences, Membrane Protein Crystallography Group, Imperial College, London SW7 2AZ, UK."},{"@value":"Human Receptor Crystallography Project, Exploratory Research for Advanced Technology (ERATO), Japan Science and Technology Agency, Yoshidakonoe-cho, Sakyo-ku, Kyoto 606-8501, Japan."},{"@value":"Department of Cell Biology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe, Sakyo-Ku, Kyoto 606-8501, Japan."},{"@value":"Astbury Centre for Structural Molecular Biology, Institute for Membrane and Systems Biology, University of Leeds, Leeds LS2 9JT, UK."}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943841144326","@type":"Researcher","foaf:name":[{"@value":"Elisabeth P. Carpenter"}],"jpcoar:affiliationName":[{"@value":"Membrane Protein Laboratory, Diamond Light Source Limited, Harwell Science and Innovation Campus, Chilton, Didcot, Oxfordshire OX11 0DE, UK."},{"@value":"Division of Molecular Biosciences, Membrane Protein Crystallography Group, Imperial College, London SW7 2AZ, UK."},{"@value":"Human Receptor Crystallography Project, Exploratory Research for Advanced Technology (ERATO), Japan Science and Technology Agency, Yoshidakonoe-cho, Sakyo-ku, Kyoto 606-8501, Japan."},{"@value":"Department of Cell Biology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe, Sakyo-Ku, Kyoto 606-8501, Japan."},{"@value":"Astbury Centre for Structural Molecular Biology, Institute for Membrane and Systems Biology, University of Leeds, Leeds LS2 9JT, UK."}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943841144321","@type":"Researcher","foaf:name":[{"@value":"Nicholas G. Rutherford"}],"jpcoar:affiliationName":[{"@value":"Membrane Protein Laboratory, Diamond Light Source Limited, Harwell Science and Innovation Campus, Chilton, Didcot, Oxfordshire OX11 0DE, UK."},{"@value":"Division of Molecular Biosciences, Membrane Protein Crystallography Group, Imperial College, London SW7 2AZ, UK."},{"@value":"Human Receptor Crystallography Project, Exploratory Research for Advanced Technology (ERATO), Japan Science and Technology Agency, Yoshidakonoe-cho, Sakyo-ku, Kyoto 606-8501, Japan."},{"@value":"Department of Cell Biology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe, Sakyo-Ku, Kyoto 606-8501, Japan."},{"@value":"Astbury Centre for Structural Molecular Biology, Institute for Membrane and Systems Biology, University of Leeds, Leeds LS2 9JT, UK."}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943841144194","@type":"Researcher","foaf:name":[{"@value":"Jonathan M. Hadden"}],"jpcoar:affiliationName":[{"@value":"Membrane Protein Laboratory, Diamond Light Source Limited, Harwell Science and Innovation Campus, Chilton, Didcot, Oxfordshire OX11 0DE, UK."},{"@value":"Division of Molecular Biosciences, Membrane Protein Crystallography Group, Imperial College, London SW7 2AZ, UK."},{"@value":"Human Receptor Crystallography Project, Exploratory Research for Advanced Technology (ERATO), Japan Science and Technology Agency, Yoshidakonoe-cho, Sakyo-ku, Kyoto 606-8501, Japan."},{"@value":"Department of Cell Biology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe, Sakyo-Ku, Kyoto 606-8501, Japan."},{"@value":"Astbury Centre for Structural Molecular Biology, Institute for Membrane and Systems Biology, University of Leeds, Leeds LS2 9JT, UK."}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943841144320","@type":"Researcher","foaf:name":[{"@value":"John O'Reilly"}],"jpcoar:affiliationName":[{"@value":"Membrane Protein Laboratory, Diamond Light Source Limited, Harwell Science and Innovation Campus, Chilton, Didcot, Oxfordshire OX11 0DE, UK."},{"@value":"Division of Molecular Biosciences, Membrane Protein Crystallography Group, Imperial College, London SW7 2AZ, UK."},{"@value":"Human Receptor Crystallography Project, Exploratory Research for Advanced Technology (ERATO), Japan Science and Technology Agency, Yoshidakonoe-cho, Sakyo-ku, Kyoto 606-8501, Japan."},{"@value":"Department of Cell Biology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe, Sakyo-Ku, Kyoto 606-8501, Japan."},{"@value":"Astbury Centre for Structural Molecular Biology, Institute for Membrane and Systems Biology, University of Leeds, Leeds LS2 9JT, UK."}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943841144192","@type":"Researcher","foaf:name":[{"@value":"Pikyee Ma"}],"jpcoar:affiliationName":[{"@value":"Membrane Protein Laboratory, Diamond Light Source Limited, Harwell Science and Innovation Campus, Chilton, Didcot, Oxfordshire OX11 0DE, UK."},{"@value":"Division of Molecular Biosciences, Membrane Protein Crystallography Group, Imperial College, London SW7 2AZ, UK."},{"@value":"Human Receptor Crystallography Project, Exploratory Research for Advanced Technology (ERATO), Japan Science and Technology Agency, Yoshidakonoe-cho, Sakyo-ku, Kyoto 606-8501, Japan."},{"@value":"Department of Cell Biology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe, Sakyo-Ku, Kyoto 606-8501, Japan."},{"@value":"Astbury Centre for Structural Molecular Biology, Institute for Membrane and Systems Biology, University of Leeds, Leeds LS2 9JT, UK."}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943841144193","@type":"Researcher","foaf:name":[{"@value":"Massoud Saidijam"}],"jpcoar:affiliationName":[{"@value":"Membrane Protein Laboratory, Diamond Light Source Limited, Harwell Science and Innovation Campus, Chilton, Didcot, Oxfordshire OX11 0DE, UK."},{"@value":"Division of Molecular Biosciences, Membrane Protein Crystallography Group, Imperial College, London SW7 2AZ, UK."},{"@value":"Human Receptor Crystallography Project, Exploratory Research for Advanced Technology (ERATO), Japan Science and Technology Agency, Yoshidakonoe-cho, Sakyo-ku, Kyoto 606-8501, Japan."},{"@value":"Department of Cell Biology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe, Sakyo-Ku, Kyoto 606-8501, Japan."},{"@value":"Astbury Centre for Structural Molecular Biology, Institute for Membrane and Systems Biology, University of Leeds, Leeds LS2 9JT, UK."}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943841144202","@type":"Researcher","foaf:name":[{"@value":"Simon G. Patching"}],"jpcoar:affiliationName":[{"@value":"Membrane Protein Laboratory, Diamond Light Source Limited, Harwell Science and Innovation Campus, Chilton, Didcot, Oxfordshire OX11 0DE, UK."},{"@value":"Division of Molecular Biosciences, Membrane Protein Crystallography Group, Imperial College, London SW7 2AZ, UK."},{"@value":"Human Receptor Crystallography Project, Exploratory Research for Advanced Technology (ERATO), Japan Science and Technology Agency, Yoshidakonoe-cho, Sakyo-ku, Kyoto 606-8501, Japan."},{"@value":"Department of Cell Biology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe, Sakyo-Ku, Kyoto 606-8501, Japan."},{"@value":"Astbury Centre for Structural Molecular Biology, Institute for Membrane and Systems Biology, University of Leeds, Leeds LS2 9JT, UK."}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943841144196","@type":"Researcher","foaf:name":[{"@value":"Ryan J. Hope"}],"jpcoar:affiliationName":[{"@value":"Membrane Protein Laboratory, Diamond Light Source Limited, Harwell Science and Innovation Campus, Chilton, Didcot, Oxfordshire OX11 0DE, UK."},{"@value":"Division of Molecular Biosciences, Membrane Protein Crystallography Group, Imperial College, London SW7 2AZ, UK."},{"@value":"Human Receptor Crystallography Project, Exploratory Research for Advanced Technology (ERATO), Japan Science and Technology Agency, Yoshidakonoe-cho, Sakyo-ku, Kyoto 606-8501, Japan."},{"@value":"Department of Cell Biology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe, Sakyo-Ku, Kyoto 606-8501, Japan."},{"@value":"Astbury Centre for Structural Molecular Biology, Institute for Membrane and Systems Biology, University of Leeds, Leeds LS2 9JT, UK."}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943841144198","@type":"Researcher","foaf:name":[{"@value":"Halina T. Norbertczak"}],"jpcoar:affiliationName":[{"@value":"Membrane Protein Laboratory, Diamond Light Source Limited, Harwell Science and Innovation Campus, Chilton, Didcot, Oxfordshire OX11 0DE, UK."},{"@value":"Division of Molecular Biosciences, Membrane Protein Crystallography Group, Imperial College, London SW7 2AZ, UK."},{"@value":"Human Receptor Crystallography Project, Exploratory Research for Advanced Technology (ERATO), Japan Science and Technology Agency, Yoshidakonoe-cho, Sakyo-ku, Kyoto 606-8501, Japan."},{"@value":"Department of Cell Biology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe, Sakyo-Ku, Kyoto 606-8501, Japan."},{"@value":"Astbury Centre for Structural Molecular Biology, Institute for Membrane and Systems Biology, University of Leeds, Leeds LS2 9JT, UK."}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943841144323","@type":"Researcher","foaf:name":[{"@value":"Peter C. J. Roach"}],"jpcoar:affiliationName":[{"@value":"Membrane Protein Laboratory, Diamond Light Source Limited, Harwell Science and Innovation Campus, Chilton, Didcot, Oxfordshire OX11 0DE, UK."},{"@value":"Division of Molecular Biosciences, Membrane Protein Crystallography Group, Imperial College, London SW7 2AZ, UK."},{"@value":"Human Receptor Crystallography Project, Exploratory Research for Advanced Technology (ERATO), Japan Science and Technology Agency, Yoshidakonoe-cho, Sakyo-ku, Kyoto 606-8501, Japan."},{"@value":"Department of Cell Biology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe, Sakyo-Ku, Kyoto 606-8501, Japan."},{"@value":"Astbury Centre for Structural Molecular Biology, Institute for Membrane and Systems Biology, University of Leeds, Leeds LS2 9JT, UK."}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943841144201","@type":"Researcher","foaf:name":[{"@value":"So Iwata"}],"jpcoar:affiliationName":[{"@value":"Membrane Protein Laboratory, Diamond Light Source Limited, Harwell Science and Innovation Campus, Chilton, Didcot, Oxfordshire OX11 0DE, UK."},{"@value":"Division of Molecular Biosciences, Membrane Protein Crystallography Group, Imperial College, London SW7 2AZ, UK."},{"@value":"Human Receptor Crystallography Project, Exploratory Research for Advanced Technology (ERATO), Japan Science and Technology Agency, Yoshidakonoe-cho, Sakyo-ku, Kyoto 606-8501, Japan."},{"@value":"Department of Cell Biology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe, Sakyo-Ku, Kyoto 606-8501, Japan."},{"@value":"Astbury Centre for Structural Molecular Biology, Institute for Membrane and Systems Biology, University of Leeds, Leeds LS2 9JT, UK."}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943841144200","@type":"Researcher","foaf:name":[{"@value":"Peter J. F. Henderson"}],"jpcoar:affiliationName":[{"@value":"Membrane Protein Laboratory, Diamond Light Source Limited, Harwell Science and Innovation Campus, Chilton, Didcot, Oxfordshire OX11 0DE, UK."},{"@value":"Division of Molecular Biosciences, Membrane Protein Crystallography Group, Imperial College, London SW7 2AZ, UK."},{"@value":"Human Receptor Crystallography Project, Exploratory Research for Advanced Technology (ERATO), Japan Science and Technology Agency, Yoshidakonoe-cho, Sakyo-ku, Kyoto 606-8501, Japan."},{"@value":"Department of Cell Biology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe, Sakyo-Ku, Kyoto 606-8501, Japan."},{"@value":"Astbury Centre for Structural Molecular Biology, Institute for Membrane and Systems Biology, University of Leeds, Leeds LS2 9JT, UK."}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943841144327","@type":"Researcher","foaf:name":[{"@value":"Alexander D. Cameron"}],"jpcoar:affiliationName":[{"@value":"Membrane Protein Laboratory, Diamond Light Source Limited, Harwell Science and Innovation Campus, Chilton, Didcot, Oxfordshire OX11 0DE, UK."},{"@value":"Division of Molecular Biosciences, Membrane Protein Crystallography Group, Imperial College, London SW7 2AZ, UK."},{"@value":"Human Receptor Crystallography Project, Exploratory Research for Advanced Technology (ERATO), Japan Science and Technology Agency, Yoshidakonoe-cho, Sakyo-ku, Kyoto 606-8501, Japan."},{"@value":"Department of Cell Biology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe, Sakyo-Ku, Kyoto 606-8501, Japan."},{"@value":"Astbury Centre for Structural Molecular Biology, Institute for Membrane and Systems Biology, University of Leeds, Leeds LS2 9JT, UK."}]}],"contributor":[{"@id":"https://cir.nii.ac.jp/crid/1890020692765304714","@type":"Researcher","foaf:name":[{"@value":"University of Leeds"}]},{"@id":"https://cir.nii.ac.jp/crid/1890020692765304835","@type":"Researcher","foaf:name":[{"@value":"Department of Information and Image Science ; Chiba University"}]},{"@id":"https://cir.nii.ac.jp/crid/1890020692765304716","@type":"Researcher","foaf:name":[{"@value":"The Astbury Centre for Structural Molecular Biology ; University of Leeds"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00368075"},{"@type":"EISSN","@value":"10959203"}],"prism:publicationName":[{"@value":"Science"}],"dc:publisher":[{"@value":"American Association for the Advancement of Science 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