{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362262943869699712.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1373/clinchem.2006.078980"}},{"identifier":{"@type":"URI","@value":"http://academic.oup.com/clinchem/article-pdf/53/1/71/32690225/clinchem0071.pdf"}},{"identifier":{"@type":"NAID","@value":"30009891588"}}],"dc:title":[{"@value":"γ-Glutamyltransferase as a Predictor of Chronic Kidney Disease in Nonhypertensive and Nondiabetic Korean Men"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:p>Background: Little research has been done to examine whether γ-glutamyltransferase (GGT) is prospectively associated with the development of chronic kidney disease (CKD). We performed a prospective study to examine the association between GGT and the risk for the development of CKD.</jats:p><jats:p>Methods: The study cohort included a total of 10 337 healthy males with normal baseline kidney functions and no proteinuria. Participants were workers in a semiconductor manufacturing company and its 13 affiliates. CKD was defined as either the presence of proteinuria or a glomerular filtration rate (GFR) of &lt;60 mL · min−1 · (1.732)−1. Cox proportional hazards models were used to calculate the adjusted hazard ratios in separate models for CKD.</jats:p><jats:p>Results: During a follow-up period of 25 774.4 person-years, 366 men developed CKD. After adjustments were made for age, baseline GFR, triglyceride, and HDL-C, the risk for CKD increased with an increasing quartile of serum GGT (p for trend &lt;0.001). The top one fourth of serum GGT vs the bottom one fourth of relative risks for CKD was 1.90 (95% confidence interval, 1.37–2.63). These associations were also apparent in participants who consumed ≤20 g/day of alcohol and those with normal weight, with values of alanine aminotransferase within reference intervals, or with C-reactive protein &lt;3.0 mg/L, and participants without metabolic syndrome.</jats:p><jats:p>Conclusions: Our findings, which were obtained from a large work-site cohort and excluded individuals with diabetes and hypertension, indicated that serum GGT may be an early predictor for the development of CKD, independent of baseline confounding factors.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382262943869699715","@type":"Researcher","foaf:name":[{"@value":"Seungho Ryu"}],"jpcoar:affiliationName":[{"@value":"Department of Occupational Medicine and Health Screening Center,"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943869699713","@type":"Researcher","foaf:name":[{"@value":"Yoosoo Chang"}],"jpcoar:affiliationName":[{"@value":"Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine. Seoul, Korea"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943869699716","@type":"Researcher","foaf:name":[{"@value":"Dong-Il Kim"}],"jpcoar:affiliationName":[{"@value":"Department of Occupational Medicine and Health Screening Center,"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943869699714","@type":"Researcher","foaf:name":[{"@value":"Won Sool Kim"}],"jpcoar:affiliationName":[{"@value":"Department of Occupational Medicine and Health Screening Center,"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943869699712","@type":"Researcher","foaf:name":[{"@value":"Byung-Seong Suh"}],"jpcoar:affiliationName":[{"@value":"Department of Occupational Medicine and Health Screening Center,"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00099147"},{"@type":"EISSN","@value":"15308561"},{"@type":"PISSN","@value":"https://id.crossref.org/issn/00099147"}],"prism:publicationName":[{"@value":"Clinical Chemistry"}],"dc:publisher":[{"@value":"Oxford University Press (OUP)"}],"prism:publicationDate":"2007-01-01","prism:volume":"53","prism:number":"1","prism:startingPage":"71","prism:endingPage":"77"},"reviewed":"false","dc:rights":["https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model"],"url":[{"@id":"http://academic.oup.com/clinchem/article-pdf/53/1/71/32690225/clinchem0071.pdf"}],"createdAt":"2006-11-17","modifiedAt":"2021-08-04","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360285711053929984","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Association between serum γ-glutamyltranspeptidase and atherosclerosis: a population-based cross-sectional study"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567185732692992","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The modest alcohol consumption reduces the incidence of fatty liver in men: a population‐based large‐scale cohort study"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848665297286784","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Elevated Serum Gamma-Glutamyltransferase (GGT) Activity and the Development of Chronic Kidney Disease (CKD) in Cigarette Smokers"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951794115243904","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Fatty liver index is independently associated with deterioration of renal function during a 10-year period in healthy subjects"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205103136896","@type":"Article","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Association Between Serum Gamma-Glutamyltransferase Level and Prehypertension Among US Adults"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679647876864","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Nonalcoholic fatty liver disease remission in men through regular exercise"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679849866624","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The Development of Chronic Kidney Disease in Japanese Patients with Non-alcoholic Fatty Liver Disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680084615936","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Relationship Between γ-Glutamyltransferase Levels and Left Ventricular Diastolic Dysfunction"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282763016084352","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Metabolically healthy obesity and risk of leukoaraiosis; 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