{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362262943893344896.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.lfs.2009.07.017"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0024320509003282?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0024320509003282?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"19683013"}}],"dc:title":[{"@value":"Dose dependent development of diabetes mellitus and non-alcoholic steatohepatitis in monosodium glutamate-induced obese mice"}],"description":[{"notation":[{"@value":"We have recently reported that monosodium glutamate (MSG) induces severe obesity with diabetes mellitus and/or non-alcoholic fatty liver disease (NAFLD)/non-alcoholic steatohepatitis (NASH) in Crj:CD-1(ICR) neonatal mice. In this study, we investigated the effects of varying the dose of MSG on the resulting obesity and diabetes mellitus.Crj:CD-1(ICR) neonatal mice were administered MSG in one of several courses: once-daily subcutaneous injections of 2mg/g for 5 consecutive days (2 mg/g x 5 group), a single subcutaneous injection of 4 mg/g (4 mg/g x 1 group) and once-daily subcutaneous injections of 4 mg/g for 5 consecutive days (4 mg/g x 5 group).In all the MSG treatment groups, severe obesity developed by 29 weeks of age. The onset of diabetes mellitus and liver lesions (resembling those of human NAFLD/NASH) were observed before 54 weeks of age. The obesity, diabetes mellitus and liver lesions were most severe in the 4 mg/g x 1 group. In the 4 mg/g x 5 group, increases in body weight and body length were inhibited by MSG's severe toxicity.A single 4 mg/g dose of MSG is the most suitable as the obese model and induces not only severe obesity and diabetes mellitus, but also liver changes resembling human NAFLD/NASH. A small amount of MSG in the newborn develops obesity and the other complications without hyperphagia after a long term."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382262943893344905","@type":"Researcher","foaf:name":[{"@value":"Yoshiyuki Sasaki"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943893344903","@type":"Researcher","foaf:name":[{"@value":"Wataru Suzuki"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943893344901","@type":"Researcher","foaf:name":[{"@value":"Tsutomu Shimada"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943893344900","@type":"Researcher","foaf:name":[{"@value":"Seiichi Iizuka"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943893344906","@type":"Researcher","foaf:name":[{"@value":"Satoko Nakamura"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943893344902","@type":"Researcher","foaf:name":[{"@value":"Mitsunobu Nagata"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943893344896","@type":"Researcher","foaf:name":[{"@value":"Makoto 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