{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362262943894196352.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1523/jneurosci.4592-11.2012"}},{"identifier":{"@type":"URI","@value":"https://syndication.highwire.org/content/doi/10.1523/JNEUROSCI.4592-11.2012"}}],"dc:title":[{"@value":"Functional Expansion of Sensorimotor Representation and Structural Reorganization of Callosal Connections in Lower Limb Amputees"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Previous studies have indicated that amputation or deafferentation of a limb induces functional changes in sensory (S1) and motor (M1) cortices, related to phantom limb pain. However, the extent of cortical reorganization after lower limb amputation in patients with nonpainful phantom phenomena remains uncertain. In this study, we combined functional magnetic resonance (fMRI) and diffusion tensor imaging (DTI) to investigate the existence and extent of cortical and callosal plasticity in these subjects. Nine “painless” patients with lower limb amputation and nine control subjects (sex- and age-matched) underwent a 3-T MRI protocol, including fMRI with somatosensory stimulation. In amputees, we observed an expansion of activation maps of the stump in S1 and M1 of the deafferented hemisphere, spreading to neighboring regions that represent the trunk and upper limbs. We also observed that tactile stimulation of the intact foot in amputees induced a greater activation of ipsilateral S1, when compared with controls. These results demonstrate a functional remapping of S1 in lower limb amputees. However, in contrast to previous studies, these neuroplastic changes do not appear to be dependent on phantom pain but do also occur in those who reported only the presence of phantom sensation without pain. In addition, our findings indicate that amputation of a limb also induces changes in the cortical representation of the intact limb. Finally, DTI analysis showed structural changes in the corpus callosum of amputees, compatible with the hypothesis that phantom sensations may depend on inhibitory release in the sensorimotor cortex.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380579818538245252","@type":"Researcher","foaf:name":[{"@value":"Elington L. Simões"}]},{"@id":"https://cir.nii.ac.jp/crid/1380579818538245248","@type":"Researcher","foaf:name":[{"@value":"Ivanei Bramati"}]},{"@id":"https://cir.nii.ac.jp/crid/1380579818538245253","@type":"Researcher","foaf:name":[{"@value":"Erika Rodrigues"}]},{"@id":"https://cir.nii.ac.jp/crid/1380579818538245250","@type":"Researcher","foaf:name":[{"@value":"Ana Franzoi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380579818538245254","@type":"Researcher","foaf:name":[{"@value":"Jorge Moll"}]},{"@id":"https://cir.nii.ac.jp/crid/1380579818538245251","@type":"Researcher","foaf:name":[{"@value":"Roberto Lent"}]},{"@id":"https://cir.nii.ac.jp/crid/1380579818538245249","@type":"Researcher","foaf:name":[{"@value":"Fernanda Tovar-Moll"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"02706474"},{"@type":"EISSN","@value":"15292401"}],"prism:publicationName":[{"@value":"The Journal of Neuroscience"}],"dc:publisher":[{"@value":"Society for Neuroscience"}],"prism:publicationDate":"2012-02-29","prism:volume":"32","prism:number":"9","prism:startingPage":"3211","prism:endingPage":"3220"},"reviewed":"false","dc:rights":["https://creativecommons.org/licenses/by-nc-sa/4.0/"],"url":[{"@id":"https://syndication.highwire.org/content/doi/10.1523/JNEUROSCI.4592-11.2012"}],"createdAt":"2012-03-01","modifiedAt":"2023-04-13","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004232393891840","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Maladaptive change of body representation in the brain after damage to central or peripheral nervous system"}]},{"@id":"https://cir.nii.ac.jp/crid/1360013168756997248","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Brain Reorganization and Neural Plasticity in Elite Athletes With Physical Impairments"}]},{"@id":"https://cir.nii.ac.jp/crid/1360286992143226880","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Functional plasticity of the ipsilateral primary sensorimotor cortex in an elite long jumper with below-knee amputation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565168620868224","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Motor Control and Neural Plasticity through Interhemispheric Interactions"}]},{"@id":"https://cir.nii.ac.jp/crid/1360579811539694592","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Relationship Between Body-Specific Attention to a Paretic Limb and Real-World Arm Use in Stroke Patients: A Longitudinal Study"}]},{"@id":"https://cir.nii.ac.jp/crid/1360845539113319424","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Cortical reorganization of lower-limb motor representations in an elite archery athlete with congenital amputation of both arms"}]},{"@id":"https://cir.nii.ac.jp/crid/1360857593751837568","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Body-Specific Attention to the Hands and Feet in Healthy Adults"}]},{"@id":"https://cir.nii.ac.jp/crid/1390564238098333184","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Functional and structural brain changes in patients with phantom limb pain"},{"@language":"ja","@value":"幻肢痛における脳の機能的・構造的変化"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1523/jneurosci.4592-11.2012"},{"@type":"CROSSREF","@value":"10.1016/j.nicl.2019.101847_references_DOI_Xqx1zPJUhRMkx169RTH5MMNcZQR"},{"@type":"CROSSREF","@value":"10.1155/2012/823285_references_DOI_Xqx1zPJUhRMkx169RTH5MMNcZQR"},{"@type":"CROSSREF","@value":"10.3389/fnsys.2021.806257_references_DOI_Xqx1zPJUhRMkx169RTH5MMNcZQR"},{"@type":"CROSSREF","@value":"10.1016/j.neures.2015.12.015_references_DOI_Xqx1zPJUhRMkx169RTH5MMNcZQR"},{"@type":"CROSSREF","@value":"10.11154/pain.34.1_references_DOI_Xqx1zPJUhRMkx169RTH5MMNcZQR"},{"@type":"CROSSREF","@value":"10.3389/fnsys.2021.805746_references_DOI_Xqx1zPJUhRMkx169RTH5MMNcZQR"},{"@type":"CROSSREF","@value":"10.1249/jes.0000000000000288_references_DOI_Xqx1zPJUhRMkx169RTH5MMNcZQR"},{"@type":"CROSSREF","@value":"10.1016/j.nicl.2019.102144_references_DOI_Xqx1zPJUhRMkx169RTH5MMNcZQR"}]}