{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362262943927060352.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1158/0008-5472.can-04-1476"}},{"identifier":{"@type":"URI","@value":"https://aacrjournals.org/cancerres/article-pdf/64/19/6919/2518434/zch01904006919.pdf"}},{"identifier":{"@type":"PMID","@value":"15466182"}}],"dc:title":[{"@value":"Spontaneous Mutations in Digestive Tract of Old Mice Show Tissue-Specific Patterns of Genomic Instability"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title>\n               <jats:p>In an attempt to evaluate the possible role of mutations in the age-dependent increase of tumor incidence, we studied the mutational burden that accumulates in the aging process in different parts of the digestive tract in mice. The mutations were monitored in lacZ genes integrated in the mouse genome. The digestive tract was divided into the esophagus, stomach, proximal, medial, and distal part of the small intestine, and the colon. Epithelial tissues were separated from these tissues with the exception of the esophagus, in which case the whole tissue was examined. At a young age, the mutant frequencies as well as the molecular nature of the mutations were similar among the tissues examined. In old age, on the other hand, mutant frequencies were elevated to different degrees among the tissues; they were high in the small intestine and colon, intermediate in the stomach, and low in the esophagus. The molecular characteristics of the mutations also revealed distinct tissue-specificity; there were elevated rates of a small deletion mutation in the esophagus, G:C to T:A transversion in the proximal small intestine, and multiple mutations in the distal small intestine and colon. The results indicate that different parts of the digestive tract suffer from different kinds of mutational stress in the aging process. The nature of the multiple mutations suggests the presence of a mutator phenotype based on an imbalance in deoxyribonucleotide pools.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382262943927060352","@type":"Researcher","foaf:name":[{"@value":"Tetsuya Ono"}],"jpcoar:affiliationName":[{"@value":"1Genome and Radiation Biology and Divisions of"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943927060358","@type":"Researcher","foaf:name":[{"@value":"Hironobu Ikehata"}],"jpcoar:affiliationName":[{"@value":"1Genome and Radiation Biology and Divisions of"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943927060355","@type":"Researcher","foaf:name":[{"@value":"Vishnu Priya Pithani"}],"jpcoar:affiliationName":[{"@value":"1Genome and Radiation Biology and Divisions of"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943927060359","@type":"Researcher","foaf:name":[{"@value":"Yoshihiko Uehara"}],"jpcoar:affiliationName":[{"@value":"1Genome and Radiation Biology and Divisions of"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943927060357","@type":"Researcher","foaf:name":[{"@value":"Yali Chen"}],"jpcoar:affiliationName":[{"@value":"1Genome and Radiation Biology and Divisions of"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943927060354","@type":"Researcher","foaf:name":[{"@value":"Yoshitaka Kinouchi"}],"jpcoar:affiliationName":[{"@value":"2Gastroenterology, Graduate School of Medicine, Tohoku University, Sendai, Japan; and"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943927060356","@type":"Researcher","foaf:name":[{"@value":"Toru Shimosegawa"}],"jpcoar:affiliationName":[{"@value":"2Gastroenterology, Graduate School of Medicine, Tohoku University, Sendai, Japan; and"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943927060353","@type":"Researcher","foaf:name":[{"@value":"Yoshio Hosoi"}],"jpcoar:affiliationName":[{"@value":"3Department of Radiation Research, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00085472"},{"@type":"EISSN","@value":"15387445"}],"prism:publicationName":[{"@value":"Cancer Research"}],"dc:publisher":[{"@value":"American Association for Cancer Research (AACR)"}],"prism:publicationDate":"2004-10-01","prism:volume":"64","prism:number":"19","prism:startingPage":"6919","prism:endingPage":"6923"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"https://aacrjournals.org/cancerres/article-pdf/64/19/6919/2518434/zch01904006919.pdf"}],"createdAt":"2005-09-20","modifiedAt":"2022-06-16","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Aging","dc:title":"Aging"},{"@id":"https://cir.nii.ac.jp/all?q=Colon","dc:title":"Colon"},{"@id":"https://cir.nii.ac.jp/all?q=Stomach","dc:title":"Stomach"},{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Transgenic","dc:title":"Mice, Transgenic"},{"@id":"https://cir.nii.ac.jp/all?q=DNA","dc:title":"DNA"},{"@id":"https://cir.nii.ac.jp/all?q=Digestive%20System%20Neoplasms","dc:title":"Digestive System Neoplasms"},{"@id":"https://cir.nii.ac.jp/all?q=Genomic%20Instability","dc:title":"Genomic Instability"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Esophagus","dc:title":"Esophagus"},{"@id":"https://cir.nii.ac.jp/all?q=Digestive%20System%20Physiological%20Phenomena","dc:title":"Digestive System Physiological Phenomena"},{"@id":"https://cir.nii.ac.jp/all?q=Intestine,%20Small","dc:title":"Intestine, Small"},{"@id":"https://cir.nii.ac.jp/all?q=Mutation","dc:title":"Mutation"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360005520490992640","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Interstitial chromosomal deletion of the tuberous sclerosis complex 2 locus is a signature for radiation‐associated renal tumors in Eker rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285707328572800","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Effects of calorie restriction on the age-dependent accumulation of mutations in the small intestine of lacZ-transgenic mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567180090988160","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Cancer prevention by adult‐onset calorie restriction after infant exposure to ionizing radiation in B6C3F1 male mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205257945600","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The Maintenance of Genome Integrity is Tissue-Specific"},{"@language":"ja-Kana","@value":"Maintenance of Genome Integrity is Tissue Specific"}]},{"@id":"https://cir.nii.ac.jp/crid/2051433316888967936","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Alterations in the mutagenicity and mutation spectrum induced by benzo[a]pyrene instilled in the lungs of gpt delta mice of various ages"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1158/0008-5472.can-04-1476"},{"@type":"OPENAIRE","@value":"doi_dedup___::057d75249a27998002ab894efddac2b5"},{"@type":"CROSSREF","@value":"10.1111/cas.14307_references_DOI_YPBrgkptC0rvtzsxD73F8CLCqN9"},{"@type":"CROSSREF","@value":"10.1002/ijc.28751_references_DOI_YPBrgkptC0rvtzsxD73F8CLCqN9"},{"@type":"CROSSREF","@value":"10.1186/s41021-015-0004-x_references_DOI_YPBrgkptC0rvtzsxD73F8CLCqN9"},{"@type":"CROSSREF","@value":"10.3123/jemsge.28.16_references_DOI_YPBrgkptC0rvtzsxD73F8CLCqN9"},{"@type":"CROSSREF","@value":"10.1016/j.mad.2011.01.004_references_DOI_YPBrgkptC0rvtzsxD73F8CLCqN9"}]}