{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362262943929983360.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1111/j.1365-2249.2009.03874.x"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1365-2249.2009.03874.x"}},{"identifier":{"@type":"URI","@value":"https://academic.oup.com/cei/article-pdf/156/1/149/41925888/j.1365-2249.2009.03874.x.pdf"}}],"dc:title":[{"@value":"Cell contact, prostaglandin E2 and transforming growth factor beta 1 play non-redundant roles in human mesenchymal stem cell induction of CD4+CD25Highforkhead box P3+ regulatory T cells"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Summary</jats:title><jats:p>Adult human mesenchymal stromal or stem cells (MSC) can differentiate into a variety of cell types and are candidate cellular therapeutics in regenerative medicine. Surprisingly, these cells also display multiple potent immunomodulatory capabilities, including allosuppression, making allogeneic cell therapy a possibility. The exact mechanisms involved in regulatory T cell induction by allogeneic human MSC was examined, using purified CD4+ populations and well-characterized bone marrow-derived adult human MSC. Allogeneic MSC were shown to induce forkhead box P3 (FoxP3)+ and CD25+ mRNA and protein expression in CD4+ T cells. This phenomenon required direct contact between MSC and purified T cells, although cell contact was not required for MSC induction of FoxP3 expression in an unseparated mononuclear cell population. In addition, through use of antagonists and neutralizing antibodies, MSC-derived prostaglandins and transforming growth factor (TGF)-β1 were shown to have a non-redundant role in the induction of CD4+CD25+FoxP3+ T cells. Purified CD4+CD25+ T cells induced by MSC co-culture expressed TGF-β1 and were able to suppress alloantigen-driven proliferative responses in mixed lymphocyte reaction. These data clarify the mechanisms of human MSC-mediated allosuppression, supporting a sequential process of regulatory T cell induction involving direct MSC contact with CD4+ cells followed by both prostaglandin E2 and TGF-β1 expression. Overall, this study provides a rational basis for ongoing clinical studies involving allogeneic MSC.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004230835846912","@type":"Researcher","foaf:name":[{"@value":"K English"}],"jpcoar:affiliationName":[{"@value":"Institute of Immunology, National University of Ireland Maynooth, Maynooth, Co. Kildare"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943929983363","@type":"Researcher","foaf:name":[{"@value":"J M Ryan"}],"jpcoar:affiliationName":[{"@value":"Institute of Immunology, National University of Ireland Maynooth, Maynooth, Co. Kildare"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943929983364","@type":"Researcher","foaf:name":[{"@value":"L Tobin"}],"jpcoar:affiliationName":[{"@value":"Institute of Immunology, National University of Ireland Maynooth, Maynooth, Co. Kildare"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943929983360","@type":"Researcher","foaf:name":[{"@value":"M J Murphy"}],"jpcoar:affiliationName":[{"@value":"Regenerative Medicine Institute (REMEDI), National Centre for Biomedical Engineering Science, National University of Ireland, Galway, Ireland"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943929983362","@type":"Researcher","foaf:name":[{"@value":"F P Barry"}],"jpcoar:affiliationName":[{"@value":"Regenerative Medicine Institute (REMEDI), National Centre for Biomedical Engineering Science, National University of Ireland, Galway, Ireland"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262943929983365","@type":"Researcher","foaf:name":[{"@value":"B P Mahon"}],"jpcoar:affiliationName":[{"@value":"Institute of Immunology, National University of Ireland Maynooth, Maynooth, Co. Kildare"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"13652249"},{"@type":"PISSN","@value":"00099104"}],"prism:publicationName":[{"@value":"Clinical and Experimental Immunology"}],"dc:publisher":[{"@value":"Oxford University Press (OUP)"}],"prism:publicationDate":"2009-02-03","prism:volume":"156","prism:number":"1","prism:startingPage":"149","prism:endingPage":"160"},"reviewed":"false","dc:rights":["https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1365-2249.2009.03874.x"},{"@id":"https://academic.oup.com/cei/article-pdf/156/1/149/41925888/j.1365-2249.2009.03874.x.pdf"}],"createdAt":"2009-02-03","modifiedAt":"2024-03-09","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004230835847040","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Allogeneic Transplantation of Fetal Membrane-Derived Mesenchymal Stem Cells: Therapy for Acute Myocarditis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285710794104192","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Immunomodulatory effects of stem cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360302864800447104","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Mesenchymal stem cells as therapeutic vehicles for glioma"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565170866409344","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Transplanted Bone Marrow–Derived Circulating PDGFRα+ Cells Restore Type VII Collagen in Recessive Dystrophic Epidermolysis Bullosa Mouse Skin Graft"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565170866719232","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Induction of Regulatory T Cells and Its Regulation with Insulin-like Growth Factor/Insulin-like Growth Factor Binding Protein-4 by Human Mesenchymal Stem Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567188091427712","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Serum-Starved Adipose-Derived Stromal Cells Ameliorate Crescentic GN by Promoting Immunoregulatory Macrophages"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567189641719040","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Mechanisms of the immunosuppressive effects of mouse adipose tissue-derived mesenchymal stromal cells on mouse alloreactively stimulated spleen cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360572092652405888","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The Regulatory Role of T Cell Responses in Cardiac Remodeling Following Myocardial Infarction"}]},{"@id":"https://cir.nii.ac.jp/crid/1360580230607745024","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Endogenous reparative pluripotent Muse cells with a unique immune privilege system: Hint at a new strategy for controlling acute and chronic inflammation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360584339750767744","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Biomimetic polyelectrolyte coating of stem cells suppresses thrombotic activation and enhances its survival and function"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846645443607424","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Mesenchymal stromal cells inhibit Th17 but not regulatory T-cell differentiation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360861705585606784","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Human Amniotic Fluid Stem Cells Ameliorate Thioglycollate-Induced Peritonitis by Increasing Tregs in Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1361975844245456512","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Periodontal Ligament Stem Cells: Regenerative Potency in Periodontium"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680234548608","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Defining mesenchymal stromal cells responsiveness to IFNγ as a surrogate measure of suppressive potency"},{"@value":"Defining mesenchymal stromal cells responsiveness to IFN^|^gamma; 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