{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362262943982065536.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1191/0748233701th093oa"}},{"identifier":{"@type":"URI","@value":"https://journals.sagepub.com/doi/pdf/10.1191/0748233701th093oa"}}],"dc:title":[{"@value":"Effects of butylparaben on the male reproductive system in rats"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p> Parabens are a group of compounds widely used as preservatives in foodstuffs, cosmetics, toiletries and pharmaceuticals. These compounds are known to exert a weak estrogenic activity, with butylparaben showing the most potent activity among methyl-, ethyl- and propyl esters in in vitro recombinant yeast assay and in in vivo uterotrophic assay. To account for potential reproductive effects in male animals, butylparaben was administered to 3-week- old Wistar rats divided in groups of eight subjects, at doses of 0.00%, 0.01%, 0.10% and 1.00% with the animal’s diet. After 8 weeks, the rats were killed by decapitation and the weights of the testes, epididymides, prostates, seminal vesicles and preputial glands were recorded. The absolute and relative weights of epididymides were decreased in a dose-dependent manner and the decrease was statistically significant at 0.10% and above. The cauda epididymal sperm reserve of all treated groups was significantly decreased. The sperm count of the group receiving the highest dose was 58.2% of control values. The daily sperm production (DSP) in the testis was also significantly lower in all treated groups when compared to controls. Serum testosterone concentration was lowered dose-dependently and was significant at 0.1% or more. The daily intake of butylparaben that caused these disruptions is similar to the lower level of acceptable daily intake (ADI) for parabens in the European Community (EC) and in Japan. The results of the present experiments show for the first time that exposure of a postweaning mammal to butylparaben had an adverse effect on the secretion of testosterone and in the functions of the male reproductive system. </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382262943982065536","@type":"Researcher","foaf:name":[{"@value":"Shinshi Oishi"}],"jpcoar:affiliationName":[{"@value":"Department of Toxicology, Tokyo Metropolitan Research Laboratory of Public Health, 3-24-1, Hyakunin-cho, Shinjuku-ku, Tokyo 169-0073, Japan,"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"07482337"},{"@type":"EISSN","@value":"14770393"},{"@type":"PISSN","@value":"https://id.crossref.org/issn/07482337"}],"prism:publicationName":[{"@value":"Toxicology and Industrial Health"}],"dc:publisher":[{"@value":"SAGE Publications"}],"prism:publicationDate":"2001-02","prism:volume":"17","prism:number":"1","prism:startingPage":"31","prism:endingPage":"39"},"reviewed":"false","dc:rights":["https://journals.sagepub.com/page/policies/text-and-data-mining-license"],"url":[{"@id":"https://journals.sagepub.com/doi/pdf/10.1191/0748233701th093oa"}],"createdAt":"2002-07-27","modifiedAt":"2025-01-27","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360302865729760128","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Temporal trends in exposure to parabens, benzophenones, triclosan, and triclocarban in adult females in Kyoto, Japan, from 1993 to 2016"}]},{"@id":"https://cir.nii.ac.jp/crid/1360566397225032320","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Paraben exposure and semen quality of Japanese male partners of subfertile couples"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848657407542272","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Urinary excretion of parabens in pregnant Japanese women"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204498188288","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Androgenic and Antiandrogenic Effects of Alkylphenols and Parabens Assessed Using the Reporter Gene Assay with Stably Transfected CHO-K1 Cells (AR-EcoScreen System)"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680174149504","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Parabens and Phenoxyethanol Amounts in Commercial Lipsticks and Their Daily Intake"},{"@language":"ja","@value":"市販口紅中のパラベン類およびフェノキシエタノール含有量とその摂取量の推定"},{"@language":"ja-Kana","@value":"シハン クチベニ チュウ ノ パラベンルイ オヨビ フェノキシエタノール ガンユウリョウ ト ソノ セッシュリョウ ノ スイテイ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680487132672","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Embryo- and Testicular-toxicities of Methoxyacetate and the Related: a Review on Possible Roles of One-carbon Transfer and Histone Modification"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282681405997568","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Maternal Isobutyl-Paraben Exposure decreases the Plasma Corticosterone Level in Dams and Sensitivity to Estrogen in Female Offspring Rats"},{"@value":"Physiology: Maternal isobutyl-paraben exposure decreases the plasma corticosterone level in dams and sensitivity to estrogen in female offspring rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1390293401256102912","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The effects on growth and reproductive function by parabens in <i>C. elegans</i>"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1191/0748233701th093oa"},{"@type":"CROSSREF","@value":"10.1292/jvms.71.1027_references_DOI_3Csw5nNQ6LYS8m1fvkG7zlltyF4"},{"@type":"CROSSREF","@value":"10.1007/s11356-024-33627-w_references_DOI_3Csw5nNQ6LYS8m1fvkG7zlltyF4"},{"@type":"CROSSREF","@value":"10.1186/s12199-017-0618-7_references_DOI_3Csw5nNQ6LYS8m1fvkG7zlltyF4"},{"@type":"CROSSREF","@value":"10.2740/jisdh.20.143_references_DOI_3Csw5nNQ6LYS8m1fvkG7zlltyF4"},{"@type":"CROSSREF","@value":"10.2131/fts.9.145_references_DOI_3Csw5nNQ6LYS8m1fvkG7zlltyF4"},{"@type":"CROSSREF","@value":"10.1248/jhs.51.557_references_DOI_3Csw5nNQ6LYS8m1fvkG7zlltyF4"},{"@type":"CROSSREF","@value":"10.1016/j.reprotox.2012.07.004_references_DOI_3Csw5nNQ6LYS8m1fvkG7zlltyF4"},{"@type":"CROSSREF","@value":"10.14252/foodsafetyfscj.2015013_references_DOI_3Csw5nNQ6LYS8m1fvkG7zlltyF4"}]}