{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362262944185879936.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1007/s00198-006-0077-2"}},{"identifier":{"@type":"URI","@value":"http://link.springer.com/content/pdf/10.1007/s00198-006-0077-2.pdf"}},{"identifier":{"@type":"URI","@value":"http://link.springer.com/article/10.1007/s00198-006-0077-2/fulltext.html"}},{"identifier":{"@type":"URI","@value":"http://link.springer.com/content/pdf/10.1007/s00198-006-0077-2"}},{"identifier":{"@type":"PMID","@value":"16520888"}}],"dc:title":[{"@value":"ALDH2 polymorphisms and bone mineral density in an elderly Japanese population"}],"description":[{"notation":[{"@value":"Osteoporosis is a multifactorial genetic disease which greatly increases the risk of bone fracture in elderly persons.Four hundred and three recipients of a community health screening program were examined for the presence/absence of osteoporosis and 11 kinds of gene polymorphisms as a means of determining the relation between these gene polymorphisms and osteoporosis. The gene polymorphisms screened were: alcohol sensitivity-associated polymorphisms of alcohol dehydrogenase (ADH2) Arg47His, aldehyde dehydrogenase (ALDH2) Glu487Lys, smoking sensitivity-associated polymorphisms of glutathione S transferase (GST) M1, (GST)T1, NAD(P)H quinone oxidoreductase 1 (NQO1) C609T, inflammation-associated polymorphisms of interleukin-1beta (IL-1B)T-31C, tumor necrosis factor alpha (TNF-alpha) T-1031C, endothelial constitutive nitric oxide synthase (ecNOS) Glu298Asp, longevity-associated polymorphism of mitochondrial DNA (mtDNA) 5178 A/C, allergy-associated polymorphism of interleukin-4 (IL-4), and immunity-associated polymorphism of CD14.A significant association was found between the ALDH2Glu478Lys gene polymorphisms and osteoporosis. In the osteoporosis group of patients, a significant difference was noted between the Lys/Lys group and the group comprising Glu/Lys and Glu/Glu groups (namely, the genotypes including Glu alleles). In the Lys/Lys group, after age, sex, BMI, smoking history and alcohol consumption history had been adjusted for, the morbidity rate was significantly elevated [odds ratio (OR): 3.33; 95% confidence interval (95% CI): 1.28-8.71; p=0.014], and the effect was even more evident in the sub-group of women with osteoporosis (OR: 4.31; 95% CI: 1.24-14.92; p=0.021).The present results suggest that active prophylactic interventions such as dietary, exercise, and pharmacological therapies should be offered to non-carriers of the Glu allele (Lys/Lys)."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004231180912392","@type":"Researcher","foaf:name":[{"@value":"J. Yamaguchi"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262944185879936","@type":"Researcher","foaf:name":[{"@value":"Y. Hasegawa"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262944185879938","@type":"Researcher","foaf:name":[{"@value":"M. Kawasaki"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262944185879937","@type":"Researcher","foaf:name":[{"@value":"T. Masui"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262944185879941","@type":"Researcher","foaf:name":[{"@value":"T. Kanoh"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262944185879939","@type":"Researcher","foaf:name":[{"@value":"N. Ishiguro"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262944185879942","@type":"Researcher","foaf:name":[{"@value":"N. Hamajima"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"0937941X"},{"@type":"EISSN","@value":"14332965"}],"prism:publicationName":[{"@value":"Osteoporosis International"}],"dc:publisher":[{"@value":"Springer Science and Business Media LLC"}],"prism:publicationDate":"2006-03-07","prism:volume":"17","prism:number":"6","prism:startingPage":"908","prism:endingPage":"913"},"reviewed":"false","dc:rights":["http://www.springer.com/tdm"],"url":[{"@id":"http://link.springer.com/content/pdf/10.1007/s00198-006-0077-2.pdf"},{"@id":"http://link.springer.com/article/10.1007/s00198-006-0077-2/fulltext.html"},{"@id":"http://link.springer.com/content/pdf/10.1007/s00198-006-0077-2"}],"createdAt":"2006-03-06","modifiedAt":"2019-05-23","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Aged,%2080%20and%20over","dc:title":"Aged, 80 and over"},{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Polymorphism,%20Genetic","dc:title":"Polymorphism, Genetic"},{"@id":"https://cir.nii.ac.jp/all?q=Aldehyde%20Dehydrogenase","dc:title":"Aldehyde Dehydrogenase"},{"@id":"https://cir.nii.ac.jp/all?q=Middle%20Aged","dc:title":"Middle Aged"},{"@id":"https://cir.nii.ac.jp/all?q=Cohort%20Studies","dc:title":"Cohort Studies"},{"@id":"https://cir.nii.ac.jp/all?q=Calcaneus","dc:title":"Calcaneus"},{"@id":"https://cir.nii.ac.jp/all?q=Asian%20People","dc:title":"Asian People"},{"@id":"https://cir.nii.ac.jp/all?q=Japan","dc:title":"Japan"},{"@id":"https://cir.nii.ac.jp/all?q=Bone%20Density","dc:title":"Bone Density"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Osteoporosis","dc:title":"Osteoporosis"},{"@id":"https://cir.nii.ac.jp/all?q=Female","dc:title":"Female"},{"@id":"https://cir.nii.ac.jp/all?q=Genetic%20Predisposition%20to%20Disease","dc:title":"Genetic Predisposition to Disease"},{"@id":"https://cir.nii.ac.jp/all?q=Aged","dc:title":"Aged"},{"@id":"https://cir.nii.ac.jp/all?q=Ultrasonography","dc:title":"Ultrasonography"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004231180912256","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Disruption of the Aldehyde Dehydrogenase 2 Gene Results in No Increase in Trabecular Bone Mass Due to Skeletal Loading in Association with Impaired Cell Cycle Regulation Through p21 Expression in the Bone Marrow Cells of 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