{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362262944339443328.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1002/hbm.20889"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fhbm.20889"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/hbm.20889"}}],"dc:title":[{"@value":"Neuronal network pharmacodynamics of GABAergic modulation in the human cortex determined using pharmaco‐magnetoencephalography"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:p>Neuronal network oscillations are a unifying phenomenon in neuroscience research, with comparable measurements across scales and species. Cortical oscillations are of central importance in the characterization of neuronal network function in health and disease and are influential in effective drug development. Whilst animal in vitro and in vivo electrophysiology is able to characterize pharmacologically induced modulations in neuronal activity, present human counterparts have spatial and temporal limitations. Consequently, the potential applications for a human equivalent are extensive. Here, we demonstrate a novel implementation of contemporary neuroimaging methods called pharmaco‐magnetoencephalography. This approach determines the spatial profile of neuronal network oscillatory power change across the cortex following drug administration and reconstructs the time course of these modulations at focal regions of interest. As a proof of concept, we characterize the nonspecific GABAergic modulator diazepam, which has a broad range of therapeutic applications. We demonstrate that diazepam variously modulates θ (4–7 Hz), α (7–14 Hz), β (15–25 Hz), and γ (30–80 Hz) frequency oscillations in specific regions of the cortex, with a pharmacodynamic profile consistent with that of drug uptake. We examine the relevance of these results with regard to the spatial and temporal observations from other modalities and the various therapeutic consequences of diazepam and discuss the potential applications of such an approach in terms of drug development and translational neuroscience. Hum Brain Mapp, 2010. © 2009 Wiley‐Liss, Inc.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382262944339443331","@type":"Researcher","foaf:name":[{"@value":"Stephen D. Hall"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262944339443330","@type":"Researcher","foaf:name":[{"@value":"Gareth R. Barnes"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262944339443328","@type":"Researcher","foaf:name":[{"@value":"Paul L. Furlong"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262944339443332","@type":"Researcher","foaf:name":[{"@value":"Stefano Seri"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262944339443329","@type":"Researcher","foaf:name":[{"@value":"Arjan Hillebrand"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"10659471"},{"@type":"EISSN","@value":"10970193"}],"prism:publicationName":[{"@value":"Human Brain Mapping"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2010-03-10","prism:volume":"31","prism:number":"4","prism:startingPage":"581","prism:endingPage":"594"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fhbm.20889"},{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/hbm.20889"}],"createdAt":"2009-11-23","modifiedAt":"2023-10-10","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004239452100224","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Repetitive Passive Finger Movement Modulates Primary Somatosensory Cortex Excitability"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567182348928768","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The inhibition/excitation ratio related to task-induced oscillatory modulations during a working memory task: A multtimodal-imaging study using MEG and MRS"}]},{"@id":"https://cir.nii.ac.jp/crid/1360588379365878400","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Neural mechanisms underlying the after-effects of repetitive paired-pulse TMS with β tACS on the human primary motor cortex"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848656262063360","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Variability and Reliability of Paired-Pulse Depression and Cortical Oscillation Induced by Median Nerve Stimulation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360853567764118784","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Menstrual Cycle Modulates Motor Learning and Memory Consolidation in Humans"}]},{"@id":"https://cir.nii.ac.jp/crid/1360865814756177408","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Does 20 Hz Transcranial Alternating Current Stimulation over the Human Primary Motor Cortex Modulate Beta Rebound Following Voluntary Movement?"}]},{"@id":"https://cir.nii.ac.jp/crid/1360865815514064384","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Motor-Related Mu/Beta Rhythm in Older Adults: A Comprehensive Review"}]},{"@id":"https://cir.nii.ac.jp/crid/1361412892042254464","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Transcranial static magnetic stimulation —From bench to bedside and beyond—"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1002/hbm.20889"},{"@type":"CROSSREF","@value":"10.3389/fnhum.2018.00332_references_DOI_GGCmpnRpSAnLpIZ3fKjoEJ7PNG9"},{"@type":"CROSSREF","@value":"10.1016/j.neuroimage.2015.12.057_references_DOI_GGCmpnRpSAnLpIZ3fKjoEJ7PNG9"},{"@type":"CROSSREF","@value":"10.1016/j.neures.2019.12.005_references_DOI_GGCmpnRpSAnLpIZ3fKjoEJ7PNG9"},{"@type":"CROSSREF","@value":"10.1038/s41598-025-92444-4_references_DOI_GGCmpnRpSAnLpIZ3fKjoEJ7PNG9"},{"@type":"CROSSREF","@value":"10.1007/s10548-018-0648-5_references_DOI_GGCmpnRpSAnLpIZ3fKjoEJ7PNG9"},{"@type":"CROSSREF","@value":"10.3390/brainsci10100696_references_DOI_GGCmpnRpSAnLpIZ3fKjoEJ7PNG9"},{"@type":"CROSSREF","@value":"10.3390/brainsci14010074_references_DOI_GGCmpnRpSAnLpIZ3fKjoEJ7PNG9"},{"@type":"CROSSREF","@value":"10.3390/brainsci13050751_references_DOI_GGCmpnRpSAnLpIZ3fKjoEJ7PNG9"}]}