{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362262944740378624.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1073/pnas.1008155107"}},{"identifier":{"@type":"URI","@value":"https://pnas.org/doi/pdf/10.1073/pnas.1008155107"}}],"dc:title":[{"@value":"Nanoparticles activate the NLR pyrin domain containing 3 (Nlrp3) inflammasome and cause pulmonary inflammation through release of IL-1α and IL-1β"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>\n            Nanoparticles are increasingly used in various fields, including biomedicine and electronics. One application utilizes the opacifying effect of nano-TiO\n            <jats:sub>2</jats:sub>\n            , which is frequently used as pigment in cosmetics. Although TiO\n            <jats:sub>2</jats:sub>\n            is believed to be biologically inert, an emerging literature reports increased incidence of respiratory diseases in people exposed to TiO\n            <jats:sub>2</jats:sub>\n            . Here, we show that nano-TiO\n            <jats:sub>2</jats:sub>\n            and nano-SiO\n            <jats:sub>2</jats:sub>\n            , but not nano-ZnO, activate the NLR pyrin domain containing 3 (Nlrp3) inflammasome, leading to IL-1β release and in addition, induce the regulated release of IL-1α. Unlike other particulate Nlrp3 agonists, nano-TiO\n            <jats:sub>2</jats:sub>\n            –dependent-Nlrp3 activity does not require cytoskeleton-dependent phagocytosis and induces IL-1α/β secretion in nonphagocytic keratinocytes. Inhalation of nano-TiO\n            <jats:sub>2</jats:sub>\n            provokes lung inflammation which is strongly suppressed in IL-1R– and IL-1α–deficient mice. Thus, the inflammation caused by nano-TiO\n            <jats:sub>2</jats:sub>\n            in vivo is largely caused by the biological effect of IL-1α. The current use of nano-TiO\n            <jats:sub>2</jats:sub>\n            may present a health hazard due to its capacity to induce IL-1R signaling, a situation reminiscent of inflammation provoked by asbestos exposure.\n          </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380294645653429378","@type":"Researcher","foaf:name":[{"@value":"Amir S. Yazdi"}],"jpcoar:affiliationName":[{"@value":"Department of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland; and"}]},{"@id":"https://cir.nii.ac.jp/crid/1380294645653429376","@type":"Researcher","foaf:name":[{"@value":"Greta Guarda"}],"jpcoar:affiliationName":[{"@value":"Department of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland; and"}]},{"@id":"https://cir.nii.ac.jp/crid/1380294645653429381","@type":"Researcher","foaf:name":[{"@value":"Nicolas Riteau"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Molecular Immunology and Embryology, University of Orleans and Centre National de la Recherche Scientifique, F-45071 Orleans, France"}]},{"@id":"https://cir.nii.ac.jp/crid/1380294645653429248","@type":"Researcher","foaf:name":[{"@value":"Stefan K. Drexler"}],"jpcoar:affiliationName":[{"@value":"Department of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland; and"}]},{"@id":"https://cir.nii.ac.jp/crid/1380294645653429379","@type":"Researcher","foaf:name":[{"@value":"Aubry Tardivel"}],"jpcoar:affiliationName":[{"@value":"Department of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland; and"}]},{"@id":"https://cir.nii.ac.jp/crid/1380294645653429380","@type":"Researcher","foaf:name":[{"@value":"Isabelle Couillin"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Molecular Immunology and Embryology, University of Orleans and Centre National de la Recherche Scientifique, F-45071 Orleans, France"}]},{"@id":"https://cir.nii.ac.jp/crid/1380294645653429377","@type":"Researcher","foaf:name":[{"@value":"Jürg Tschopp"}],"jpcoar:affiliationName":[{"@value":"Department of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland; and"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00278424"},{"@type":"EISSN","@value":"10916490"}],"prism:publicationName":[{"@value":"Proceedings of the National Academy of Sciences"}],"dc:publisher":[{"@value":"Proceedings of the National Academy of Sciences"}],"prism:publicationDate":"2010-10-25","prism:volume":"107","prism:number":"45","prism:startingPage":"19449","prism:endingPage":"19454"},"reviewed":"false","url":[{"@id":"https://pnas.org/doi/pdf/10.1073/pnas.1008155107"}],"createdAt":"2010-10-26","modifiedAt":"2022-04-13","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360002219439630848","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Effect of Silica Particle Size on Macrophage Inflammatory Responses"}]},{"@id":"https://cir.nii.ac.jp/crid/1360002220514974720","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Nanosilica-induced placental inflammation and pregnancy complications: Different roles of the inflammasome components NLRP3 and ASC"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004230168071936","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Exogenous nanoparticles and endogenous crystalline molecules as danger signals for the NLRP3 inflammasomes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004232532501632","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Purinergic signaling via P2X7 receptor mediates IL-1β production in Kupffer cells exposed to silica nanoparticle"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004239436930560","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Human Scavenger Receptor A1-Mediated Inflammatory Response to Silica Particle Exposure Is Size Specific"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004239437383680","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Macrophage Recognition of Crystals and Nanoparticles"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004239692365952","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"NF‑κB inhibitor DHMEQ inhibits titanium dioxide nanoparticle‑induced interleukin‑1β production: Inhibition of the PM2.5‑induced inflammation model"}]},{"@id":"https://cir.nii.ac.jp/crid/1360009142620842752","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Oral intake of silica nanoparticles exacerbates intestinal 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monocytes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285707285553536","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Danger of frustrated sensors: Role of Toll-like receptors and NOD-like receptors in aseptic and septic inflammations around total hip replacements"}]},{"@id":"https://cir.nii.ac.jp/crid/1360294643771426432","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Amorphous silica nanoparticles (nSP50) exacerbate hepatic damage through the activation of acquired cell-mediated immunity"}]},{"@id":"https://cir.nii.ac.jp/crid/1360302865747779968","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Dasatinib suppresses particulate-induced pyroptosis and acute lung 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