{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362262944914977408.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1161/circinterventions.109.910638"}},{"identifier":{"@type":"URI","@value":"https://www.ahajournals.org/doi/full/10.1161/CIRCINTERVENTIONS.109.910638"}}],"dc:title":[{"@value":"Does Safe Dosing of Iodinated Contrast Prevent Contrast-Induced Acute Kidney Injury?"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:sec>\n            <jats:title>Background—</jats:title>\n            <jats:p>Previous work on contrast-induced acute kidney injury (CI-AKI) has identified contrast volume as a risk factor and suggested that there is a maximum allowable contrast dose (MACD) above which the risk of CI-AKI is markedly increased. We hypothesized that there is a relationship between contrast volume and CI-AKI and that there might be reason to track incremental contrast volumes above and below the MACD limit.</jats:p>\n          </jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results—</jats:title>\n            <jats:p>\n              Consecutive patients undergoing percutaneous coronary intervention (PCI) were prospectively enrolled from 2000 to 2008 (n=10 065). Patients on dialysis before PCI were excluded (n=155). MACD was defined as (5 mL×body weight [kg])/baseline serum creatinine [mg/dL]) and divided into categories in which 1.0 reflects the MACD limit: ≤MACD ratios (<0.5, 0.5 to 0.75, and 0.75 to 1.0) and >MACD (1.0 to 1.5, 1.5 to 2.0, and >2.0). CI-AKI was defined as a ≥0.3 (mg/dL) or ≥50% increase in serum creatinine from baseline or new dialysis. Multivariable regression was conducted to evaluate the effect of exceeding the MACD on CI-AKI. Twenty percent of patients exceeded the MACD. Risk-adjusted CI-AKI increased by an average of 45% for each category exceeding the MACD (odds ratio, 1.45; 95% confidence interval, 1.29 to 1.62) Adjusted odds ratios for each category exceeding the MACD were 1.60 (95% confidence interval, 1.29 to 1.97), 2.02 (95% confidence interval, 1.45 to 2.81), and 2.94 (95% confidence interval, 1.93 to 4.48). CI-AKI for contrast dose <MACD showed no statistical difference (\n              <jats:italic>P</jats:italic>\n              =0.5).\n            </jats:p>\n          </jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions—</jats:title>\n            <jats:p>Contrast volume is a key risk factor for CI-AKI and matters the most in the highest-risk patient. The incremental use of contrast beyond the MACD is associated with an increased risk of CI-AKI.</jats:p>\n          </jats:sec>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382262944914977412","@type":"Researcher","foaf:name":[{"@value":"Jeremiah R. Brown"}],"jpcoar:affiliationName":[{"@value":"From the Dartmouth Institute for Health Policy and Clinical Practice (J.R.B., G.T.O., D.J.M.), Dartmouth College, Lebanon, NH; the Section of Cardiology (J.R.B., J.F.R., A.V.K., D.J.M.) and the Section of Nephrology/Hypertension (C.A.B., A.C.S.), Department of Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH; and the Department of Renal Services (R.J.S.), Fletcher Allen Health Care, Burlington, VT."}]},{"@id":"https://cir.nii.ac.jp/crid/1382262944914977409","@type":"Researcher","foaf:name":[{"@value":"John F. Robb"}],"jpcoar:affiliationName":[{"@value":"From the Dartmouth Institute for Health Policy and Clinical Practice (J.R.B., G.T.O., D.J.M.), Dartmouth College, Lebanon, NH; the Section of Cardiology (J.R.B., J.F.R., A.V.K., D.J.M.) and the Section of Nephrology/Hypertension (C.A.B., A.C.S.), Department of Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH; and the Department of Renal Services (R.J.S.), Fletcher Allen Health Care, Burlington, VT."}]},{"@id":"https://cir.nii.ac.jp/crid/1382262944914977408","@type":"Researcher","foaf:name":[{"@value":"Clay A. Block"}],"jpcoar:affiliationName":[{"@value":"From the Dartmouth Institute for Health Policy and Clinical Practice (J.R.B., G.T.O., D.J.M.), Dartmouth College, Lebanon, NH; the Section of Cardiology (J.R.B., J.F.R., A.V.K., D.J.M.) and the Section of Nephrology/Hypertension (C.A.B., A.C.S.), Department of Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH; and the Department of Renal Services (R.J.S.), Fletcher Allen Health Care, Burlington, VT."}]},{"@id":"https://cir.nii.ac.jp/crid/1382262944914977413","@type":"Researcher","foaf:name":[{"@value":"Anton C. Schoolwerth"}],"jpcoar:affiliationName":[{"@value":"From the Dartmouth Institute for Health Policy and Clinical Practice (J.R.B., G.T.O., D.J.M.), Dartmouth College, Lebanon, NH; the Section of Cardiology (J.R.B., J.F.R., A.V.K., D.J.M.) and the Section of Nephrology/Hypertension (C.A.B., A.C.S.), Department of Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH; and the Department of Renal Services (R.J.S.), Fletcher Allen Health Care, Burlington, VT."}]},{"@id":"https://cir.nii.ac.jp/crid/1382262944914977414","@type":"Researcher","foaf:name":[{"@value":"Aaron V. Kaplan"}],"jpcoar:affiliationName":[{"@value":"From the Dartmouth Institute for Health Policy and Clinical Practice (J.R.B., G.T.O., D.J.M.), Dartmouth College, Lebanon, NH; the Section of Cardiology (J.R.B., J.F.R., A.V.K., D.J.M.) and the Section of Nephrology/Hypertension (C.A.B., A.C.S.), Department of Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH; and the Department of Renal Services (R.J.S.), Fletcher Allen Health Care, Burlington, VT."}]},{"@id":"https://cir.nii.ac.jp/crid/1382262944914977415","@type":"Researcher","foaf:name":[{"@value":"Gerald T. O'Connor"}],"jpcoar:affiliationName":[{"@value":"From the Dartmouth Institute for Health Policy and Clinical Practice (J.R.B., G.T.O., D.J.M.), Dartmouth College, Lebanon, NH; the Section of Cardiology (J.R.B., J.F.R., A.V.K., D.J.M.) and the Section of Nephrology/Hypertension (C.A.B., A.C.S.), Department of Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH; and the Department of Renal Services (R.J.S.), Fletcher Allen Health Care, Burlington, VT."}]},{"@id":"https://cir.nii.ac.jp/crid/1382262944914977411","@type":"Researcher","foaf:name":[{"@value":"Richard J. Solomon"}],"jpcoar:affiliationName":[{"@value":"From the Dartmouth Institute for Health Policy and Clinical Practice (J.R.B., G.T.O., D.J.M.), Dartmouth College, Lebanon, NH; the Section of Cardiology (J.R.B., J.F.R., A.V.K., D.J.M.) and the Section of Nephrology/Hypertension (C.A.B., A.C.S.), Department of Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH; and the Department of Renal Services (R.J.S.), Fletcher Allen Health Care, Burlington, VT."}]},{"@id":"https://cir.nii.ac.jp/crid/1382262944914977410","@type":"Researcher","foaf:name":[{"@value":"David J. Malenka"}],"jpcoar:affiliationName":[{"@value":"From the Dartmouth Institute for Health Policy and Clinical Practice (J.R.B., G.T.O., D.J.M.), Dartmouth College, Lebanon, NH; the Section of Cardiology (J.R.B., J.F.R., A.V.K., D.J.M.) and the Section of Nephrology/Hypertension (C.A.B., A.C.S.), Department of Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH; and the Department of Renal Services (R.J.S.), Fletcher Allen Health Care, Burlington, VT."}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"19417640"},{"@type":"EISSN","@value":"19417632"}],"prism:publicationName":[{"@value":"Circulation: Cardiovascular Interventions"}],"dc:publisher":[{"@value":"Ovid Technologies (Wolters Kluwer Health)"}],"prism:publicationDate":"2010-08","prism:volume":"3","prism:number":"4","prism:startingPage":"346","prism:endingPage":"350"},"reviewed":"false","url":[{"@id":"https://www.ahajournals.org/doi/full/10.1161/CIRCINTERVENTIONS.109.910638"}],"createdAt":"2010-06-30","modifiedAt":"2024-05-13","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360002215978833664","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Performance and Validation of the U.S. NCDR Acute Kidney Injury Prediction Model in Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205102151936","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Pre-Procedural Glucose Levels and the Risk for Contrast-Induced Acute Kidney Injury in Patients Undergoing Emergency Coronary Intervention"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679446766848","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Transcatheter aortic valve implantation. A new therapeutic approach for patients with severe aortic stenosis and coronary artery disease"},{"@value":"冠動脈疾患を合併した重症大動脈弁狭窄症患者に対するtranscatheter aortic valve implantation(TAVI)の適応と実際"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282752372831360","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Guideline on the Use of Iodinated Contrast Media in Patients With Kidney Disease 2018"},{"@value":"JCS GUIDELINES : Guideline on the Use of Iodinated Contrast Media in Patients With Kidney Disease 2018"}]},{"@id":"https://cir.nii.ac.jp/crid/1390854882594305024","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Clinical impact of noncontrast percutaneous coronary intervention in patients with acute coronary syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1390856893076169600","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Statin Use Influence on the Occurrence of Acute Kidney Injury in Patients with Peripheral Arterial Disease"}]},{"@id":"https://cir.nii.ac.jp/crid/2050025942143993216","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Guidelines on the use of iodinated contrast media in patients with kidney disease 2012 : digest version"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1161/circinterventions.109.910638"},{"@type":"CROSSREF","@value":"10.1253/circj.cj-19-0783_references_DOI_MJiuDEKDy93Upx1ar0xR4pTbgLY"},{"@type":"CROSSREF","@value":"10.1016/j.jacc.2016.01.049_references_DOI_MJiuDEKDy93Upx1ar0xR4pTbgLY"},{"@type":"CROSSREF","@value":"10.7793/jcoron.19.002_references_DOI_MJiuDEKDy93Upx1ar0xR4pTbgLY"},{"@type":"CROSSREF","@value":"10.1253/circj.cj-11-1248_references_DOI_MJiuDEKDy93Upx1ar0xR4pTbgLY"},{"@type":"CROSSREF","@value":"10.1007/s11604-019-00850-2_references_DOI_MJiuDEKDy93Upx1ar0xR4pTbgLY"},{"@type":"CROSSREF","@value":"10.5551/jat.63265_references_DOI_MJiuDEKDy93Upx1ar0xR4pTbgLY"},{"@type":"CROSSREF","@value":"10.2152/jmi.69.57_references_DOI_MJiuDEKDy93Upx1ar0xR4pTbgLY"},{"@type":"CROSSREF","@value":"10.1007/s11604-013-0226-4_references_DOI_MJiuDEKDy93Upx1ar0xR4pTbgLY"}]}