{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362262944953060992.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1002/gene.10092"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fgene.10092"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/gene.10092"}}],"dc:title":[{"@value":"Expression of Cre recombinase in the developing mouse limb bud driven by a <i>Prxl</i> enhancer"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:p>Summary: We have used a <jats:italic>Prx1</jats:italic> limb enhancer to drive expression of Cre Recombinase in transgenic mice. This regulatory element leads to Cre expression throughout the early limb bud mesenchyme and in a subset of craniofacial mesenchyme. Crossing a murine line carrying this transgene to a reporter mouse harboring a floxed Cre‐reporter cassette revealed that recombinase activity is first observed in the earliest limb bud at 9.5 dpc. By early to mid bud stages at 10.5 dpc recombination is essentially complete in all mesenchymal cells in the limb. Expression of the Cre recombinase was never detected in the limb bud ectoderm. The use of <jats:italic>Prx1</jats:italic>–<jats:italic>Cre</jats:italic> mice should facilitate analysis of gene function in the developing limb. genesis 33:77–80, 2002. © 2002 Wiley‐Liss, Inc.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382262944953060994","@type":"Researcher","foaf:name":[{"@value":"Malcolm Logan"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262944953060992","@type":"Researcher","foaf:name":[{"@value":"James F. Martin"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262944953060996","@type":"Researcher","foaf:name":[{"@value":"Andras Nagy"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262944953060995","@type":"Researcher","foaf:name":[{"@value":"Corrinne Lobe"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262944953060993","@type":"Researcher","foaf:name":[{"@value":"Eric N. Olson"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262944953060997","@type":"Researcher","foaf:name":[{"@value":"Clifford J. Tabin"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"1526954X"},{"@type":"EISSN","@value":"1526968X"}],"prism:publicationName":[{"@value":"genesis"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2002-05-08","prism:volume":"33","prism:number":"2","prism:startingPage":"77","prism:endingPage":"80"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fgene.10092"},{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/gene.10092"}],"createdAt":"2002-10-06","modifiedAt":"2023-11-19","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050020596872949760","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Semaphorin 6D tunes amygdalar circuits for emotional, metabolic, and inflammatory 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