{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362262945168056064.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1152/physrev.1999.79.2.387"}},{"identifier":{"@type":"URI","@value":"https://www.physiology.org/doi/pdf/10.1152/physrev.1999.79.2.387"}}],"dc:title":[{"@value":"Signaling Mechanisms Underlying the Vascular Myogenic Response"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>The vascular myogenic response refers to the acute reaction of a blood vessel to a change in transmural pressure. This response is critically important for the development of resting vascular tone, upon which other control mechanisms exert vasodilator and vasoconstrictor influences. The purpose of this review is to summarize and synthesize information regarding the cellular mechanism(s) underlying the myogenic response in blood vessels, with particular emphasis on arterioles. When necessary, experiments performed on larger blood vessels, visceral smooth muscle, and even striated muscle are cited. Mechanical aspects of myogenic behavior are discussed first, followed by electromechanical coupling mechanisms. Next, mechanotransduction by membrane-bound enzymes and involvement of second messengers, including calcium, are discussed. After this, the roles of the extracellular matrix, integrins, and the smooth muscle cytoskeleton are reviewed, with emphasis on short-term signaling mechanisms. Finally, suggestions are offered for possible future studies.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382262945168056064","@type":"Researcher","foaf:name":[{"@value":"Michael J. Davis"}],"jpcoar:affiliationName":[{"@value":"Department of Medical Physiology, Microcirculation Research Institute, Texas A&M University, College Station, Texas; and Microvascular Biology Group, Department of Human Biology and Movement Science, RMIT University, Bundoora, Victoria, Australia"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262945168056065","@type":"Researcher","foaf:name":[{"@value":"Michael A. Hill"}],"jpcoar:affiliationName":[{"@value":"Department of Medical Physiology, Microcirculation Research Institute, Texas A&M University, College Station, Texas; and Microvascular Biology Group, Department of Human Biology and Movement Science, RMIT University, Bundoora, Victoria, Australia"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00319333"},{"@type":"EISSN","@value":"15221210"},{"@type":"PISSN","@value":"http://id.crossref.org/issn/00319333"}],"prism:publicationName":[{"@value":"Physiological Reviews"}],"dc:publisher":[{"@value":"American Physiological Society"}],"prism:publicationDate":"1999-04-01","prism:volume":"79","prism:number":"2","prism:startingPage":"387","prism:endingPage":"423"},"reviewed":"false","url":[{"@id":"https://www.physiology.org/doi/pdf/10.1152/physrev.1999.79.2.387"}],"createdAt":"2017-12-24","modifiedAt":"2025-06-29","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360002218139169664","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Myogenic tone is impaired at low arterial pressure in mice deficient in the low‐voltage‐activated<scp>C</scp>a<sub>V</sub>3.1<scp>T</scp>‐type<scp>C</scp>a<sup>2+</sup>channel"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004231218196096","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Cell membrane stretch activates intermediate-conductance Ca2+-activated K+ channels in arterial smooth muscle 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Arteries"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001206126681472","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"食塩負荷から血管トーヌス亢進へのメカニズム：Na<sup>+</sup>ポンプ・Na<sup>+</sup>/Ca<sup>2+</sup>交換体共役系の役割"},{"@language":"en","@value":"Mechanisms for Linking High Salt Intake to Vascular Tone: Role of Na<sup>+</sup> Pump and Na<sup>+</sup>/Ca<sup>2+</sup> Exchanger Coupling"},{"@value":"食塩負荷から血管トーヌス亢進へのメカニズム--Na[+]ポンプ・Na[+]/Ca[2+]交換体共役系の役割"},{"@language":"ja-Kana","@value":"ショクエン フカ カラ ケッカン トーヌス コウシン エ ノ メカニズム Na ポンプ Na Ca 2 コウカンタイ キョウヤクケイ ノ ヤクワリ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679251026432","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Chemical-mechanical synergism for cardiovascular TRPC6 channel activation via PLC/diacylglycerol and PLA2/.OMEGA.-hydroxylase/20-HETE 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