{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362262945177956864.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1155/2011/317852"}},{"identifier":{"@type":"URI","@value":"http://downloads.hindawi.com/archive/2011/317852.pdf"}},{"identifier":{"@type":"URI","@value":"http://downloads.hindawi.com/archive/2011/317852.xml"}},{"identifier":{"@type":"PMID","@value":"21776384"}}],"dc:title":[{"@value":"Tyrosine Kinase Signaling in Kidney Glomerular Podocytes"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>During the last decade, several key molecules have been identified as essential components for the filtration barrier function of kidney glomerular podocytes. Mutations in genes encoding these molecules severely impair the podocyte architecture in the affected patients, leading to the development of proteinuria. Extensive investigations have been performed on the function of these molecules, which highlights the importance of tyrosine kinase signaling in the podocytes. An Src family tyrosine kinase, Fyn, plays a major role in this signaling pathway. Here, we review the current understanding of this important signal transduction system and its role in the development and the maintenance of podocytes.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382262945177956865","@type":"Researcher","foaf:name":[{"@value":"Seisuke Hattori"}],"jpcoar:affiliationName":[{"@value":"Division of Biochemistry, School of Pharmaceutical Science, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262945177956864","@type":"Researcher","foaf:name":[{"@value":"Shoichiro Kanda"}],"jpcoar:affiliationName":[{"@value":"Department of Pediatrics, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1420564276170747008","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"10451866"},{"@type":"NRID","@value":"1000010451866"},{"@type":"NRID","@value":"9000006165823"},{"@type":"NRID","@value":"9000414844239"},{"@type":"NRID","@value":"9000020184376"},{"@type":"NRID","@value":"9000014227307"},{"@type":"NRID","@value":"9000021742564"},{"@type":"NRID","@value":"9000409848589"},{"@type":"NRID","@value":"9000410743344"},{"@type":"NRID","@value":"9000253561407"},{"@type":"NRID","@value":"9000414086181"},{"@type":"NRID","@value":"9000024188613"},{"@type":"NRID","@value":"9000414940213"},{"@type":"NRID","@value":"9000021740839"},{"@type":"NRID","@value":"9000010463824"},{"@type":"NRID","@value":"9000335563795"},{"@type":"NRID","@value":"9000024202325"},{"@type":"NRID","@value":"9000413902896"},{"@type":"NRID","@value":"9000010000132"},{"@type":"NRID","@value":"9000017384720"},{"@type":"NRID","@value":"9000310331845"},{"@type":"NRID","@value":"9000024230977"},{"@type":"NRID","@value":"9000403411724"},{"@type":"NRID","@value":"9000024264816"},{"@type":"NRID","@value":"9000259294546"},{"@type":"NRID","@value":"9000356660090"},{"@type":"NRID","@value":"9000314806582"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/haritay"}],"foaf:name":[{"@value":"Yutaka Harita"}],"jpcoar:affiliationName":[{"@value":"Department of Pediatrics, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan"},{"@value":"Department of Molecular Biology, Yokohama City University School of Medicine, Kanazawa-ku, Yokohama 236-0004, Japan"},{"@value":"Division of Functional Proteomics, Graduate School of Nanobioscience, Yokohama City University Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"20901739"},{"@type":"EISSN","@value":"20901747"}],"prism:publicationName":[{"@value":"Journal of Signal Transduction"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2011-05-30","prism:volume":"2011","prism:startingPage":"1","prism:endingPage":"10"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["http://creativecommons.org/licenses/by/3.0/"],"url":[{"@id":"http://downloads.hindawi.com/archive/2011/317852.pdf"},{"@id":"http://downloads.hindawi.com/archive/2011/317852.xml"}],"createdAt":"2011-05-30","modifiedAt":"2020-12-09","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Review%20Article","dc:title":"Review Article"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360846645897002624","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The struggle for energy in podocytes leads to nephrotic syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1884242817356506240","@type":"Dataset","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Faculty Opinions recommendation of The murine nephrin gene is specifically expressed in kidney, brain and pancreas: inactivation of the gene leads to massive proteinuria and neonatal death."}]},{"@id":"https://cir.nii.ac.jp/crid/2051714792006384512","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Application of next-generation sequencing technology to diagnosis and treatment of focal segmental glomerulosclerosis"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1155/2011/317852"},{"@type":"OPENAIRE","@value":"doi_dedup___::82365c7b91b5f73184cd1639bb84f00b"},{"@type":"CROSSREF","@value":"10.1007/s10157-017-1449-y_references_DOI_XKg29KHtktMelHUTEZg2uUjVQWC"},{"@type":"CROSSREF","@value":"10.4161/cc.19825_references_DOI_XKg29KHtktMelHUTEZg2uUjVQWC"}]}