{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362262945274271104.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1152/japplphysiol.00463.2006"}},{"identifier":{"@type":"URI","@value":"https://www.physiology.org/doi/pdf/10.1152/japplphysiol.00463.2006"}},{"identifier":{"@type":"PMID","@value":"17916675"}}],"dc:title":[{"@value":"TGF-β<sub>1</sub>and TNF-α are involved in the transcription of type I collagen α<sub>2</sub>gene in soleus muscle atrophied by mechanical unloading"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>The aim of this study was to examine the effect of hindlimb suspension (HS) on the expressions of COL1A2 (type I collagen α<jats:sub>2</jats:sub>chain) mRNA and its regulatory factors, transforming growth factors (TGF)-β<jats:sub>1</jats:sub>, -β<jats:sub>2</jats:sub>, and -β<jats:sub>3</jats:sub>, phosphorylated Smad3, and tumor necrosis factor-α (TNF-α) in rat hindlimb muscles. Forty-eight male Wistar rats (age, 5 wk) were randomly assigned to HS for 1, 3, 7, and 14 days and control ( n = 6 for each). During the exposure to HS, COL1A2 mRNA expression decreased in the soleus muscle at day 3 and recovered to control level at day 7. The content of TNF-α, one of the negative regulatory factors for COL1A2, increased from day 3 until day 14. On the other hand, the contents of TGF-β<jats:sub>1</jats:sub>, TGF-β<jats:sub>3</jats:sub>, and Smad3, positive regulatory factors for COL1A2, increased at day 7. The in situ hybridization for COL1A2 and the immunohistochemistry of TGF-β<jats:sub>1</jats:sub>and TNF-α revealed their expressions around nerve-related tissues, including muscle spindles and connective tissue sheath. The results indicate that the transcriptional activity of COL1A2 in the soleus muscle initially decreases in response to unloading through an increase in TNF-α production; thereafter, it returns toward normal level through the activated TGF-β/Smad pathway.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382262945274271107","@type":"Researcher","foaf:name":[{"@value":"Tatsuro Hirose"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262945274271104","@type":"Researcher","foaf:name":[{"@value":"Koichi Nakazato"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262945274271106","@type":"Researcher","foaf:name":[{"@value":"Hongsun Song"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262945274271105","@type":"Researcher","foaf:name":[{"@value":"Naokata Ishii"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"87507587"},{"@type":"EISSN","@value":"15221601"}],"prism:publicationName":[{"@value":"Journal of Applied Physiology"}],"dc:publisher":[{"@value":"American Physiological Society"}],"prism:publicationDate":"2008-01","prism:volume":"104","prism:number":"1","prism:startingPage":"170","prism:endingPage":"177"},"reviewed":"false","url":[{"@id":"https://www.physiology.org/doi/pdf/10.1152/japplphysiol.00463.2006"}],"createdAt":"2007-10-05","modifiedAt":"2023-05-14","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Time%20Factors","dc:title":"Time Factors"},{"@id":"https://cir.nii.ac.jp/all?q=Transcription,%20Genetic","dc:title":"Transcription, Genetic"},{"@id":"https://cir.nii.ac.jp/all?q=Receptor,%20Transforming%20Growth%20Factor-beta%20Type%20I","dc:title":"Receptor, Transforming Growth Factor-beta Type I"},{"@id":"https://cir.nii.ac.jp/all?q=Protein%20Serine-Threonine%20Kinases","dc:title":"Protein Serine-Threonine Kinases"},{"@id":"https://cir.nii.ac.jp/all?q=Collagen%20Type%20I","dc:title":"Collagen Type I"},{"@id":"https://cir.nii.ac.jp/all?q=Transforming%20Growth%20Factor%20beta1","dc:title":"Transforming Growth Factor beta1"},{"@id":"https://cir.nii.ac.jp/all?q=Transforming%20Growth%20Factor%20beta2","dc:title":"Transforming Growth Factor beta2"},{"@id":"https://cir.nii.ac.jp/all?q=Transforming%20Growth%20Factor%20beta3","dc:title":"Transforming Growth Factor beta3"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=RNA,%20Messenger","dc:title":"RNA, Messenger"},{"@id":"https://cir.nii.ac.jp/all?q=Smad3%20Protein","dc:title":"Smad3 Protein"},{"@id":"https://cir.nii.ac.jp/all?q=Phosphorylation","dc:title":"Phosphorylation"},{"@id":"https://cir.nii.ac.jp/all?q=Rats,%20Wistar","dc:title":"Rats, Wistar"},{"@id":"https://cir.nii.ac.jp/all?q=Muscle,%20Skeletal","dc:title":"Muscle, Skeletal"},{"@id":"https://cir.nii.ac.jp/all?q=In%20Situ%20Hybridization","dc:title":"In Situ Hybridization"},{"@id":"https://cir.nii.ac.jp/all?q=Tumor%20Necrosis%20Factor-alpha","dc:title":"Tumor Necrosis Factor-alpha"},{"@id":"https://cir.nii.ac.jp/all?q=Body%20Weight","dc:title":"Body Weight"},{"@id":"https://cir.nii.ac.jp/all?q=Organ%20Size","dc:title":"Organ Size"},{"@id":"https://cir.nii.ac.jp/all?q=Immunohistochemistry","dc:title":"Immunohistochemistry"},{"@id":"https://cir.nii.ac.jp/all?q=Rats","dc:title":"Rats"},{"@id":"https://cir.nii.ac.jp/all?q=Disease%20Models,%20Animal","dc:title":"Disease Models, Animal"},{"@id":"https://cir.nii.ac.jp/all?q=Muscular%20Atrophy","dc:title":"Muscular Atrophy"},{"@id":"https://cir.nii.ac.jp/all?q=Hindlimb%20Suspension","dc:title":"Hindlimb Suspension"},{"@id":"https://cir.nii.ac.jp/all?q=Collagen","dc:title":"Collagen"},{"@id":"https://cir.nii.ac.jp/all?q=Activin%20Receptors,%20Type%20I","dc:title":"Activin Receptors, Type I"},{"@id":"https://cir.nii.ac.jp/all?q=Receptors,%20Transforming%20Growth%20Factor%20beta","dc:title":"Receptors, Transforming Growth Factor beta"},{"@id":"https://cir.nii.ac.jp/all?q=Signal%20Transduction","dc:title":"Signal Transduction"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050294020604874752","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Involvement of receptor for advanced glycation end products in microgravity-induced skeletal muscle atrophy in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004237596979328","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Pleiotropic Functions of High Fat Diet in the Etiology of Osteoarthritis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285711762312960","@type":"Article","resourceType":"学術雑誌論文(journal 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