{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362262945331237888.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1139/v73-032"}},{"identifier":{"@type":"URI","@value":"https://cdnsciencepub.com/doi/pdf/10.1139/v73-032"}}],"dc:title":[{"@value":"The 2,2,2-Trichloroethyl Group for Carboxyl Protection During Peptide Synthesis"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p> The 2,2,2-trichloroethyl esters of several N-carbobenzoxy-amino acids were prepared by reacting the corresponding acid chlorides with trichloroethanol and the carbobenzoxy groups were selectively removed by HBr–AcOH. The resulting esters were then coupled with various N-carbobenzoxy-amino acids or peptides using dicyclohexylcarbodiimide in acetonitrile to give N-carbobenzoxy-peptide trichloroethyl esters. The selective removal of the trichloroethyl protecting group was effected by reduction using zinc in acetic acid. The optical activity of the N-carbobenzoxy-peptides so obtained agreed well with the values reported in the literature. The overall results suggest that the 2,2,2-trichloroethyl group could be useful for carboxyl protection during peptide synthesis. </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382262945331237890","@type":"Researcher","foaf:name":[{"@value":"Bernard Marinier"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262945331237889","@type":"Researcher","foaf:name":[{"@value":"Yoon C. Kim"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262945331237888","@type":"Researcher","foaf:name":[{"@value":"Jean-Marie Navarre"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00084042"},{"@type":"EISSN","@value":"14803291"}],"prism:publicationName":[{"@value":"Canadian Journal of Chemistry"}],"dc:publisher":[{"@value":"Canadian Science Publishing"}],"prism:publicationDate":"1973-01-15","prism:volume":"51","prism:number":"2","prism:startingPage":"208","prism:endingPage":"214"},"reviewed":"false","dc:rights":["http://www.nrcresearchpress.com/page/about/CorporateTextAndDataMining"],"url":[{"@id":"https://cdnsciencepub.com/doi/pdf/10.1139/v73-032"}],"createdAt":"2006-05-04","modifiedAt":"2025-07-02","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1390282679096697600","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Synthetic studies on quinoxaline antibiotics. II. Synthesis of triostin A."}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1139/v73-032"},{"@type":"CROSSREF","@value":"10.1246/bcsj.57.2203_references_DOI_A9KsqJNLrX9P6d25ABhTDEOa3Zw"}]}