{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362262945346505216.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1128/aac.01823-12"}},{"identifier":{"@type":"URI","@value":"https://journals.asm.org/doi/pdf/10.1128/AAC.01823-12"}}],"dc:title":[{"@value":"Emergence of Imipenem-Resistant Gram-Negative Bacilli in Intestinal Flora of Intensive Care Patients"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>ABSTRACT</jats:title>\n          <jats:p>\n            Intestinal flora contains a reservoir of Gram-negative bacilli (GNB) resistant to cephalosporins, which are potentially pathogenic for intensive care unit (ICU) patients; this has led to increasing use of carbapenems. The emergence of carbapenem resistance is a major concern for ICUs. Therefore, in this study, we aimed to assess the intestinal carriage of imipenem-resistant GNB (IR-GNB) in intensive care patients. For 6 months, 523 consecutive ICU patients were screened for rectal IR-GNB colonization upon admission and weekly thereafter. The phenotypes and genotypes of all isolates were determined, and a case control study was performed to identify risk factors for colonization. The IR-GNB colonization rate increased regularly from 5.6% after 1 week to 58.6% after 6 weeks in the ICU. In all, 56 IR-GNB strains were collected from 50 patients: 36\n            <jats:named-content xmlns:xlink=\"http://www.w3.org/1999/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Pseudomonas aeruginosa</jats:named-content>\n            strains, 12\n            <jats:named-content xmlns:xlink=\"http://www.w3.org/1999/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Stenotrophomonas maltophilia</jats:named-content>\n            strains, 6\n            <jats:named-content xmlns:xlink=\"http://www.w3.org/1999/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Enterobacteriaceae</jats:named-content>\n            strains, and 2\n            <jats:named-content xmlns:xlink=\"http://www.w3.org/1999/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Acinetobacter baumannii</jats:named-content>\n            strains. In\n            <jats:named-content xmlns:xlink=\"http://www.w3.org/1999/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">P. aeruginosa</jats:named-content>\n            , imipenem resistance was due to chromosomally encoded resistance (32 strains) or carbapenemase production (4 strains). In the\n            <jats:named-content xmlns:xlink=\"http://www.w3.org/1999/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Enterobacteriaceae</jats:named-content>\n            strains, resistance was due to AmpC cephalosporinase and/or extended-spectrum β-lactamase production with porin loss. Genomic comparison showed that the strains were highly diverse, with 8 exceptions (4 VIM-2 carbapenemase-producing\n            <jats:named-content xmlns:xlink=\"http://www.w3.org/1999/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">P. aeruginosa</jats:named-content>\n            strains, 2\n            <jats:named-content xmlns:xlink=\"http://www.w3.org/1999/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Klebsiella pneumoniae</jats:named-content>\n            strains, and 2\n            <jats:named-content xmlns:xlink=\"http://www.w3.org/1999/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">S. maltophilia</jats:named-content>\n            strains). The main risk factor for IR-GNB colonization was prior imipenem exposure. The odds ratio for colonization was already as high as 5.9 (95% confidence interval [95% CI], 1.5 to 25.7) after 1 to 3 days of exposure and increased to 7.8 (95% CI, 2.4 to 29.8) thereafter. In conclusion, even brief exposure to imipenem is a major risk factor for IR-GNB carriage.\n          </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382262945346505225","@type":"Researcher","foaf:name":[{"@value":"Laurence Armand-Lefèvre"}],"jpcoar:affiliationName":[{"@value":"French National Reference Center for Bacterial Resistance in Commensal Flora, Laboratory of Bacteriology, Bichat-Claude Bernard Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France"},{"@value":"EA 3964, Denis Diderot University, Paris, France"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262945346505224","@type":"Researcher","foaf:name":[{"@value":"Cécile Angebault"}],"jpcoar:affiliationName":[{"@value":"French National Reference Center for Bacterial Resistance in Commensal Flora, Laboratory of Bacteriology, Bichat-Claude Bernard Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France"},{"@value":"EA 3964, Denis Diderot University, Paris, France"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262945346505222","@type":"Researcher","foaf:name":[{"@value":"François Barbier"}],"jpcoar:affiliationName":[{"@value":"EA 3964, Denis Diderot University, Paris, France"},{"@value":"Medical Intensive Care Unit, Bichat-Claude Bernard Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262945346505223","@type":"Researcher","foaf:name":[{"@value":"Emilie Hamelet"}],"jpcoar:affiliationName":[{"@value":"French National Reference Center for Bacterial Resistance in Commensal Flora, Laboratory of Bacteriology, Bichat-Claude Bernard Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262945346505216","@type":"Researcher","foaf:name":[{"@value":"Gilles Defrance"}],"jpcoar:affiliationName":[{"@value":"French National Reference Center for Bacterial Resistance in Commensal Flora, Laboratory of Bacteriology, Bichat-Claude Bernard Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262945346505218","@type":"Researcher","foaf:name":[{"@value":"Etienne Ruppé"}],"jpcoar:affiliationName":[{"@value":"French National Reference Center for Bacterial Resistance in Commensal Flora, Laboratory of Bacteriology, Bichat-Claude Bernard Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France"},{"@value":"EA 3964, Denis Diderot University, Paris, France"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262945346505226","@type":"Researcher","foaf:name":[{"@value":"Régis Bronchard"}],"jpcoar:affiliationName":[{"@value":"Surgical Intensive Care Unit, Bichat-Claude Bernard Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262945346505219","@type":"Researcher","foaf:name":[{"@value":"Raphaël Lepeule"}],"jpcoar:affiliationName":[{"@value":"EA 3964, Denis Diderot University, Paris, France"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262945346505227","@type":"Researcher","foaf:name":[{"@value":"Jean-Christophe Lucet"}],"jpcoar:affiliationName":[{"@value":"Infection Control Unit, Bichat-Claude Bernard Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262945346505220","@type":"Researcher","foaf:name":[{"@value":"Assiya El Mniai"}],"jpcoar:affiliationName":[{"@value":"French National Reference Center for Bacterial Resistance in Commensal Flora, Laboratory of Bacteriology, Bichat-Claude Bernard Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262945346505229","@type":"Researcher","foaf:name":[{"@value":"Michel Wolff"}],"jpcoar:affiliationName":[{"@value":"Medical Intensive Care Unit, Bichat-Claude Bernard Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262945346505228","@type":"Researcher","foaf:name":[{"@value":"Philippe Montravers"}],"jpcoar:affiliationName":[{"@value":"Surgical Intensive Care Unit, Bichat-Claude Bernard Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262945346505217","@type":"Researcher","foaf:name":[{"@value":"Patrick Plésiat"}],"jpcoar:affiliationName":[{"@value":"French National Reference Center for Pseudomonas Resistance, Jean Minjoz Hospital, EA 3186, Besançon, France"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262945346505221","@type":"Researcher","foaf:name":[{"@value":"Antoine Andremont"}],"jpcoar:affiliationName":[{"@value":"French National Reference Center for Bacterial Resistance in Commensal Flora, Laboratory of Bacteriology, Bichat-Claude Bernard Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France"},{"@value":"EA 3964, Denis Diderot University, Paris, France"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00664804"},{"@type":"EISSN","@value":"10986596"}],"prism:publicationName":[{"@value":"Antimicrobial Agents and Chemotherapy"}],"dc:publisher":[{"@value":"American Society for Microbiology"}],"prism:publicationDate":"2013-03","prism:volume":"57","prism:number":"3","prism:startingPage":"1488","prism:endingPage":"1495"},"reviewed":"false","dc:rights":["https://journals.asm.org/non-commercial-tdm-license"],"url":[{"@id":"https://journals.asm.org/doi/pdf/10.1128/AAC.01823-12"}],"createdAt":"2013-01-15","modifiedAt":"2022-02-21","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360298757452148480","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Use of broad-spectrum antimicrobials for more than 72 h and the detection of multidrug-resistant bacteria in Japanese intensive care units: a multicenter retrospective cohort study"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001288140014336","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Does Quick Sepsis-Related Organ Failure Assessment Suggest the Use of Initial Empirical Carbapenem Therapy in Bacteremia Caused by Extended-Spectrum β-Lactamase-Producing Bacteria? :A Multicenter Case-Control Study"}]},{"@id":"https://cir.nii.ac.jp/crid/1390295181711406208","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Cases of Pediatric Pyelonephritis: A Single-Center Retrospective Study from an Extended-Spectrum β-Lactamase-Producing Escherichia coli Endemic Area in Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1390587351212080512","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Retrospective evaluation of the effectiveness of flomoxef against infections with extended-spectrum β-lactamase-producing <i>Enterobacterales</i>"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1128/aac.01823-12"},{"@type":"CROSSREF","@value":"10.7883/yoken.jjid.2018.272_references_DOI_6wywE8k9UGin1944p4AvNJpfavm"},{"@type":"CROSSREF","@value":"10.1186/s13756-022-01146-3_references_DOI_6wywE8k9UGin1944p4AvNJpfavm"},{"@type":"CROSSREF","@value":"10.35772/ghmo.2025.01005_references_DOI_6wywE8k9UGin1944p4AvNJpfavm"},{"@type":"CROSSREF","@value":"10.33160/yam.2023.02.013_references_DOI_6wywE8k9UGin1944p4AvNJpfavm"}]}