{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362262945528622720.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1002/anie.201411931"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fanie.201411931"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/anie.201411931"}}],"dc:title":[{"@value":"A Highly Stabilizing Silver(I)‐Mediated Base Pair in Parallel‐Stranded DNA"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:p>The first parallel‐stranded DNA duplex with Hoogsteen base pairing that readily incorporates an Ag<jats:sup>+</jats:sup>ion into an internal mispair to form a metal‐mediated base pair has been created. Towards this end, the highly stabilizing<jats:bold>6 FP</jats:bold>‐Ag<jats:sup>+</jats:sup>‐<jats:bold>6 FP</jats:bold>base pair comprising the artificial nucleobase 6‐furylpurine (<jats:bold>6 FP</jats:bold>) was devised. A combination of temperature‐dependent UV spectroscopy, CD spectroscopy, and DFT calculations was used to confirm the formation of this base pair. The nucleobase<jats:bold>6 FP</jats:bold>is capable of forming metal‐mediated base pairs both by the Watson–Crick edge (i.e. in regular antiparallel‐stranded DNA) and by the Hoogsteen edge (i.e. in parallel‐stranded DNA), depending on the oligonucleotide sequence and the experimental conditions. The<jats:bold>6 FP</jats:bold>‐Ag<jats:sup>+</jats:sup>‐<jats:bold>6 FP</jats:bold>base pair within parallel‐stranded DNA is the most strongly stabilizing Ag<jats:sup>+</jats:sup>‐mediated base pair reported to date for any type of nucleic acid, with an increase in melting temperature of almost 15 °C upon the binding of one Ag<jats:sup>+</jats:sup>ion.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382262945528622721","@type":"Researcher","foaf:name":[{"@value":"Indranil Sinha"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262945528622720","@type":"Researcher","foaf:name":[{"@value":"Célia Fonseca Guerra"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262945528622722","@type":"Researcher","foaf:name":[{"@value":"Jens Müller"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"14337851"},{"@type":"EISSN","@value":"15213773"}],"prism:publicationName":[{"@value":"Angewandte Chemie International Edition"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2015-01-28","prism:volume":"54","prism:number":"12","prism:startingPage":"3603","prism:endingPage":"3606"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fanie.201411931"},{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/anie.201411931"}],"createdAt":"2015-01-28","modifiedAt":"2024-06-06","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004232183790592","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The effect of chemical modification of DNA base on binding of HgII and AgI in metal-mediated base pairs"}]},{"@id":"https://cir.nii.ac.jp/crid/1360005514549904000","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Silver(I)‐Ion‐Mediated Cytosine‐Containing Base Pairs: Metal Ion Specificity for Duplex Stabilization and Susceptibility toward DNA Polymerases"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565164378562816","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"High‐Resolution Crystal Structure of a Silver(I)–RNA Hybrid Duplex Containing Watson–Crick‐like CSilver(I)C Metallo‐Base Pairs"}]},{"@id":"https://cir.nii.ac.jp/crid/2050025942141186048","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Artificial DNA base pairing mediated by diverse metal ions"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1002/anie.201411931"},{"@type":"CROSSREF","@value":"10.1002/cbic.201900450_references_DOI_VxAWDJkUPFAzFw3Fdga3VIorJTP"},{"@type":"CROSSREF","@value":"10.1246/cl.160985_references_DOI_VxAWDJkUPFAzFw3Fdga3VIorJTP"},{"@type":"CROSSREF","@value":"10.1002/anie.201507894_references_DOI_VxAWDJkUPFAzFw3Fdga3VIorJTP"},{"@type":"CROSSREF","@value":"10.1016/j.ica.2016.03.007_references_DOI_VxAWDJkUPFAzFw3Fdga3VIorJTP"}]}