{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362262945694580608.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1146/annurev.cellbio.17.1.615"}},{"identifier":{"@type":"URI","@value":"https://www.annualreviews.org/doi/pdf/10.1146/annurev.cellbio.17.1.615"}},{"identifier":{"@type":"NAID","@value":"30022117434"}}],"dc:title":[{"@value":"Cellular Function of Phosphoinositide 3-Kinases: Implications for Development, Immunity, Homeostasis, and Cancer"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>▪ Abstract  The phosphoinositide 3-kinase (PI3K) family of enzymes is recruited upon growth factor receptor activation and produces 3′ phosphoinositide lipids. The lipid products of PI3K act as second messengers by binding to and activating diverse cellular target proteins. These events constitute the start of a complex signaling cascade, which ultimately results in the mediation of cellular activities such as proliferation, differentiation, chemotaxis, survival, trafficking, and glucose homeostasis. Therefore, PI3Ks play a central role in many cellular functions. The factors that determine which cellular function is mediated are complex and may be partly attributed to the diversity that exists at each level of the PI3K signaling cascade, such as the type of stimulus, the isoform of PI3K, or the nature of the second messenger lipids. Numerous studies have helped to elucidate some of the key factors that determine cell fate in the context of PI3K signaling. For example, the past two years has seen the publication of many transgenic and knockout mouse studies where either PI3K or its signaling components are deregulated. These models have helped to build a picture of the role of PI3K in physiology and indeed there have been a number of surprises. This review uses such models as a framework to build a profile of PI3K function within both the cell and the organism and focuses, in particular, on the role of PI3K in cell regulation, immunity, and development. The evidence for the role of deregulated PI3K signaling in diseases such as cancer and diabetes is reviewed.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382262945694580612","@type":"Researcher","foaf:name":[{"@value":"Roy Katso"}],"jpcoar:affiliationName":[{"@value":"Ludwig Institute for Cancer Research, 91 Riding House Street, London, W1W 7BS, England;"},{"@value":"Department of Biochemistry and Molecular Biology, Gower Street, London WC1E 6BT, England;"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262945694580608","@type":"Researcher","foaf:name":[{"@value":"Klaus Okkenhaug"}],"jpcoar:affiliationName":[{"@value":"Ludwig Institute for Cancer Research, 91 Riding House Street, London, W1W 7BS, England;"},{"@value":"Department of Biochemistry and Molecular Biology, Gower Street, London WC1E 6BT, England;"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262945694580611","@type":"Researcher","foaf:name":[{"@value":"Khatereh Ahmadi"}],"jpcoar:affiliationName":[{"@value":"Ludwig Institute for Cancer Research, 91 Riding House Street, London, W1W 7BS, England;"},{"@value":"Department of Biochemistry and Molecular Biology, Gower Street, London WC1E 6BT, England;"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262945694580613","@type":"Researcher","foaf:name":[{"@value":"Sarah White"}],"jpcoar:affiliationName":[{"@value":"Ludwig Institute for Cancer Research, 91 Riding House Street, London, W1W 7BS, England;"},{"@value":"Department of Biochemistry and Molecular Biology, Gower Street, London WC1E 6BT, England;"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262945694580609","@type":"Researcher","foaf:name":[{"@value":"John Timms"}],"jpcoar:affiliationName":[{"@value":"Ludwig Institute for Cancer Research, 91 Riding House Street, London, W1W 7BS, England;"},{"@value":"Department of Biochemistry and Molecular Biology, Gower Street, London WC1E 6BT, England;"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262945694580610","@type":"Researcher","foaf:name":[{"@value":"Michael D. Waterfield"}],"jpcoar:affiliationName":[{"@value":"Ludwig Institute for Cancer Research, 91 Riding House Street, London, W1W 7BS, England;"},{"@value":"Department of Biochemistry and Molecular Biology, Gower Street, London WC1E 6BT, England;"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"10810706"},{"@type":"EISSN","@value":"15308995"},{"@type":"PISSN","@value":"http://id.crossref.org/issn/07434634"}],"prism:publicationName":[{"@value":"Annual Review of Cell and Developmental Biology"}],"dc:publisher":[{"@value":"Annual Reviews"}],"prism:publicationDate":"2001-11","prism:volume":"17","prism:number":"1","prism:startingPage":"615","prism:endingPage":"675"},"reviewed":"false","url":[{"@id":"https://www.annualreviews.org/doi/pdf/10.1146/annurev.cellbio.17.1.615"}],"createdAt":"2002-07-27","modifiedAt":"2023-04-23","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050294045369175424","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Phosphoinositide phosphatases in cancer cell dynamics-Beyond PI3K and PTEN"},{"@value":"Phosphoinositide phosphatases in cancer cell dynamics—Beyond PI3K and PTEN"}]},{"@id":"https://cir.nii.ac.jp/crid/1050845760743713792","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Fluorescence resonance energy transfer based quantitative analysis of feedforward and feedback loops in epidermal growth factor receptor signaling and the sensitivity to molecular targeting drugs."}]},{"@id":"https://cir.nii.ac.jp/crid/1360002217131807360","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Role for B-cell adapter for PI3K (BCAP) as a signaling adapter linking Toll-like receptors (TLRs) to serine/threonine kinases PI3K/Akt"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004235783119104","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Role of Class III phosphoinositide 3‐kinase in the brain development: possible involvement in specific learning disorders"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004237864327680","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Does autophagy work in synaptic plasticity and memory?"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004239512457984","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"RNAi Therapeutic Platforms for Lung Diseases"}]},{"@id":"https://cir.nii.ac.jp/crid/1360017282201083520","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Functional and Molecular Characters of Cancer Stem Cells Through Development to Establishment"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285707146872448","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Expression pattern of class I phosphoinositide 3-kinase and distribution of its product, phosphatidylinositol-3,4,5-trisphosphate, during Drosophila embryogenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360294643803014400","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"How can we turn the PI3K/AKT/mTOR pathway down? 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