{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362262945764316544.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1073/pnas.1300981110"}},{"identifier":{"@type":"URI","@value":"https://pnas.org/doi/pdf/10.1073/pnas.1300981110"}}],"dc:title":[{"@value":"<i>Shigella</i>\n            impairs T lymphocyte dynamics in vivo"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>\n            The Gram-negative enteroinvasive bacterium\n            <jats:italic>Shigella flexneri</jats:italic>\n            is responsible for the endemic form of bacillary dysentery, an acute rectocolitis in humans.\n            <jats:italic>S. flexneri</jats:italic>\n            uses a type III secretion system to inject effector proteins into host cells, thus diverting cellular functions to its own benefit. Protective immunity to reinfection requires several rounds of infection to be elicited and is short-lasting, suggesting that\n            <jats:italic>S. flexneri</jats:italic>\n            interferes with the priming of specific immunity. Considering the key role played by T-lymphocyte trafficking in priming of adaptive immunity, we investigated the impact of\n            <jats:italic>S. flexneri</jats:italic>\n            on T-cell dynamics in vivo. By using two-photon microscopy to visualize bacterium–T-cell cross-talks in the lymph nodes, where the adaptive immunity is initiated, we provide evidence that\n            <jats:italic>S. flexneri</jats:italic>\n            , via its type III secretion system, impairs the migration pattern of CD4\n            <jats:sup>+</jats:sup>\n            T cells independently of cognate recognition of bacterial antigens. We show that bacterial invasion of CD4\n            <jats:sup>+</jats:sup>\n            T lymphocytes occurs in vivo, and results in cell migration arrest. In the absence of invasion, CD4\n            <jats:sup>+</jats:sup>\n            T-cell migration parameters are also dramatically altered. Signals resulting from\n            <jats:italic>S. flexneri</jats:italic>\n            interactions with subcapsular sinus macrophages and dendritic cells, and recruitment of polymorphonuclear cells are likely to contribute to this phenomenon. These findings indicate that\n            <jats:italic>S. flexneri</jats:italic>\n            targets T lymphocytes in vivo and highlight the role of type III effector secretion in modulating host adaptive immune responses.\n          </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380013247260193281","@type":"Researcher","foaf:name":[{"@value":"Wilmara Salgado-Pabón"}],"jpcoar:affiliationName":[{"@value":"Molecular Microbial Pathogenesis Unit, Department Cell Biology and Infection,"},{"@value":"Institut National de la Santé et de la Recherche Médicale U786,"}]},{"@id":"https://cir.nii.ac.jp/crid/1380013247260193288","@type":"Researcher","foaf:name":[{"@value":"Susanna Celli"}],"jpcoar:affiliationName":[{"@value":"Dynamics of Immune Responses Unit, Department of Immunology, Institut Pasteur, 75724 Paris Cedex 15, France"}]},{"@id":"https://cir.nii.ac.jp/crid/1380013247260193286","@type":"Researcher","foaf:name":[{"@value":"Ellen T. Arena"}],"jpcoar:affiliationName":[{"@value":"Molecular Microbial Pathogenesis Unit, Department Cell Biology and Infection,"},{"@value":"Institut National de la Santé et de la Recherche Médicale U786,"}]},{"@id":"https://cir.nii.ac.jp/crid/1380013247260193285","@type":"Researcher","foaf:name":[{"@value":"Katharina Nothelfer"}],"jpcoar:affiliationName":[{"@value":"Molecular Microbial Pathogenesis Unit, Department Cell Biology and Infection,"},{"@value":"Institut National de la Santé et de la Recherche Médicale U786,"}]},{"@id":"https://cir.nii.ac.jp/crid/1380013247260193280","@type":"Researcher","foaf:name":[{"@value":"Pascal Roux"}],"jpcoar:affiliationName":[{"@value":"Platform for Dynamic Imaging Studies, and"}]},{"@id":"https://cir.nii.ac.jp/crid/1380013247260193282","@type":"Researcher","foaf:name":[{"@value":"Gernot Sellge"}],"jpcoar:affiliationName":[{"@value":"Molecular Microbial Pathogenesis Unit, Department Cell Biology and Infection,"},{"@value":"Institut National de la Santé et de la Recherche Médicale U786,"}]},{"@id":"https://cir.nii.ac.jp/crid/1380013247260193283","@type":"Researcher","foaf:name":[{"@value":"Elisabetta Frigimelica"}],"jpcoar:affiliationName":[{"@value":"Molecular Microbial Pathogenesis Unit, Department Cell Biology and Infection,"},{"@value":"Institut National de la Santé et de la Recherche Médicale U786,"}]},{"@id":"https://cir.nii.ac.jp/crid/1380013247260193289","@type":"Researcher","foaf:name":[{"@value":"Philippe Bousso"}],"jpcoar:affiliationName":[{"@value":"Dynamics of Immune Responses Unit, Department of Immunology, Institut Pasteur, 75724 Paris Cedex 15, France"}]},{"@id":"https://cir.nii.ac.jp/crid/1380013247260193284","@type":"Researcher","foaf:name":[{"@value":"Philippe J. Sansonetti"}],"jpcoar:affiliationName":[{"@value":"Molecular Microbial Pathogenesis Unit, Department Cell Biology and Infection,"},{"@value":"Institut National de la Santé et de la Recherche Médicale U786,"}]},{"@id":"https://cir.nii.ac.jp/crid/1380013247260193287","@type":"Researcher","foaf:name":[{"@value":"Armelle Phalipon"}],"jpcoar:affiliationName":[{"@value":"Molecular Microbial Pathogenesis Unit, Department Cell Biology and Infection,"},{"@value":"Institut National de la Santé et de la Recherche Médicale U786,"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00278424"},{"@type":"EISSN","@value":"10916490"}],"prism:publicationName":[{"@value":"Proceedings of the National Academy of Sciences"}],"dc:publisher":[{"@value":"Proceedings of the National Academy of Sciences"}],"prism:publicationDate":"2013-01-24","prism:volume":"110","prism:number":"12","prism:startingPage":"4458","prism:endingPage":"4463"},"reviewed":"false","url":[{"@id":"https://pnas.org/doi/pdf/10.1073/pnas.1300981110"}],"createdAt":"2013-02-16","modifiedAt":"2022-04-13","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360565170602578688","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Shigella Manipulates Host Immune Responses by Delivering Effector Proteins with Specific Roles"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1073/pnas.1300981110"},{"@type":"CROSSREF","@value":"10.3389/fimmu.2015.00219_references_DOI_WoZ9yFDS6k12Gax0O6AvsQ4JtZA"}]}