{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362262945790103552.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1007/s11064-008-9818-2"}},{"identifier":{"@type":"URI","@value":"http://link.springer.com/content/pdf/10.1007/s11064-008-9818-2.pdf"}},{"identifier":{"@type":"URI","@value":"http://link.springer.com/article/10.1007/s11064-008-9818-2/fulltext.html"}},{"identifier":{"@type":"URI","@value":"http://link.springer.com/content/pdf/10.1007/s11064-008-9818-2"}},{"identifier":{"@type":"PMID","@value":"18751896"}}],"dc:title":[{"@value":"Brain Region-Specific Effects of Short-Term Treatment with Duloxetine, Venlafaxine, Milnacipran and Sertraline on Monoamine Metabolism in Rats"}],"description":[{"notation":[{"@value":"We examined brain region-specific changes in monoamines and metabolites, and their ratios, after short-term administration of antidepressants to rats. Serotonin noradrenaline reuptake inhibitors (SNRIs; duloxetine, venlafaxine, milnacipran) and a serotonin-selective reuptake inhibitor (SSRI; sertraline) elevated serotonin (5-HT) levels in the midbrain (MB). Duloxetine and venlafaxine increased 5-HT levels in the brainstem and 5-HT terminal areas, whereas milnacipran and sertraline increased levels in the brainstem only. Significant reductions in 5-HT turnover were observed in various forebrain regions, including the hippocampus and hypothalamus, after treatment with all of the tested drugs except for milnacipran. In addition, there was reduced 5-HT turnover in the dorsolateral frontal cortex (dlFC), the medial prefrontal cortex (mPFC), and both the dlFC and the mPFC after treatment with duloxetine, sertraline, and venlafaxine, respectively. Venlafaxine significantly increased dopamine (DA) levels in the nucleus accumbens (NAc) and the substantia nigra and decreased DA turnover in the NAc. Similar changes were observed after treatment with duloxetine and sertraline in the NAc, whereas milnacipran increased DA levels in the mPFC. Limited increases in noradrenaline levels were detected after treatment with duloxetine, venlafaxine, or sertraline, but not after treatment with milnacipran. These results show that SNRIs and SSRIs induced region-specific monoaminergic changes after short-term treatment."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382262945790103554","@type":"Researcher","foaf:name":[{"@value":"Katsumasa Muneoka"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262945790103555","@type":"Researcher","foaf:name":[{"@value":"Yukihiko Shirayama"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262945790103552","@type":"Researcher","foaf:name":[{"@value":"Morikuni Takigawa"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262945790103553","@type":"Researcher","foaf:name":[{"@value":"Seiji Shioda"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"03643190"},{"@type":"EISSN","@value":"15736903"}],"prism:publicationName":[{"@value":"Neurochemical Research"}],"dc:publisher":[{"@value":"Springer Science and Business Media LLC"}],"prism:publicationDate":"2008-08-27","prism:volume":"34","prism:number":"3","prism:startingPage":"542","prism:endingPage":"555"},"reviewed":"false","dc:rights":["http://www.springer.com/tdm"],"url":[{"@id":"http://link.springer.com/content/pdf/10.1007/s11064-008-9818-2.pdf"},{"@id":"http://link.springer.com/article/10.1007/s11064-008-9818-2/fulltext.html"},{"@id":"http://link.springer.com/content/pdf/10.1007/s11064-008-9818-2"}],"createdAt":"2008-08-26","modifiedAt":"2025-01-31","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Cyclopropanes","dc:title":"Cyclopropanes"},{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Serotonin","dc:title":"Serotonin"},{"@id":"https://cir.nii.ac.jp/all?q=Time%20Factors","dc:title":"Time Factors"},{"@id":"https://cir.nii.ac.jp/all?q=Dopamine","dc:title":"Dopamine"},{"@id":"https://cir.nii.ac.jp/all?q=Thiophenes","dc:title":"Thiophenes"},{"@id":"https://cir.nii.ac.jp/all?q=Duloxetine%20Hydrochloride","dc:title":"Duloxetine Hydrochloride"},{"@id":"https://cir.nii.ac.jp/all?q=Rats,%20Sprague-Dawley","dc:title":"Rats, Sprague-Dawley"},{"@id":"https://cir.nii.ac.jp/all?q=Norepinephrine","dc:title":"Norepinephrine"},{"@id":"https://cir.nii.ac.jp/all?q=Sertraline","dc:title":"Sertraline"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Biogenic%20Monoamines","dc:title":"Biogenic Monoamines"},{"@id":"https://cir.nii.ac.jp/all?q=Milnacipran","dc:title":"Milnacipran"},{"@id":"https://cir.nii.ac.jp/all?q=Venlafaxine%20Hydrochloride","dc:title":"Venlafaxine Hydrochloride"},{"@id":"https://cir.nii.ac.jp/all?q=Brain","dc:title":"Brain"},{"@id":"https://cir.nii.ac.jp/all?q=Homovanillic%20Acid","dc:title":"Homovanillic Acid"},{"@id":"https://cir.nii.ac.jp/all?q=Cyclohexanols","dc:title":"Cyclohexanols"},{"@id":"https://cir.nii.ac.jp/all?q=Rats","dc:title":"Rats"},{"@id":"https://cir.nii.ac.jp/all?q=Organ%20Specificity","dc:title":"Organ Specificity"},{"@id":"https://cir.nii.ac.jp/all?q=3,4-Dihydroxyphenylacetic%20Acid","dc:title":"3,4-Dihydroxyphenylacetic Acid"},{"@id":"https://cir.nii.ac.jp/all?q=Selective%20Serotonin%20Reuptake%20Inhibitors","dc:title":"Selective Serotonin Reuptake Inhibitors"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360567182513916032","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Perinatal exposure to bisphenol A enhances contextual fear memory and affects the serotoninergic system in juvenile female mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848659845926528","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Distinct effects of the serotonin–noradrenaline reuptake inhibitors milnacipran and venlafaxine on rat pineal monoamines"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282681103891200","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"GIRKチャネル阻害作用を持つ薬物の新規抗うつ様作用"},{"@language":"en","@value":"A Novel Antidepressant-like Action of Drugs Possessing GIRK Channel Blocking Action in Rats"},{"@language":"ja-Kana","@value":"GIRK チャネル ソガイ サヨウ オ モツ ヤクブツ ノ シンキ コウウツ ヨウ サヨウ"}]},{"@id":"https://cir.nii.ac.jp/crid/1881146593012510080","@type":"Dataset","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"BindingDB Entry 5336: Comparative affinity of duloxetine and venlafaxine for serotonin and norepinephrine transporters in vitro and in vivo, human serotonin receptor subtypes, and other neuronal receptors."}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1007/s11064-008-9818-2"},{"@type":"OPENAIRE","@value":"doi_dedup___::01e3ad9dc0a6952422218e164951f641"},{"@type":"CROSSREF","@value":"10.1248/yakushi.130.699_references_DOI_LhymNjp2mIm5sg4SIPQ4ShitT0P"},{"@type":"CROSSREF","@value":"10.1097/wnr.0000000000000379_references_DOI_LhymNjp2mIm5sg4SIPQ4ShitT0P"},{"@type":"CROSSREF","@value":"10.1016/j.yhbeh.2013.03.016_references_DOI_LhymNjp2mIm5sg4SIPQ4ShitT0P"}]}