{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362262945973935232.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1073/pnas.1211150109"}},{"identifier":{"@type":"URI","@value":"https://pnas.org/doi/pdf/10.1073/pnas.1211150109"}}],"dc:title":[{"@value":"Chromosomal duplication is a transient evolutionary solution to stress"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Aneuploidy, an abnormal number of chromosomes, is a widespread phenomenon found in unicellulars such as yeast, as well as in plants and in mammalians, especially in cancer. Aneuploidy is a genome-scale aberration that imposes a severe burden on the cell, yet under stressful conditions specific aneuploidies confer a selective advantage. This dual nature of aneuploidy raises the question of whether it can serve as a stable and sustainable evolutionary adaptation. To clarify this, we conducted a set of laboratory evolution experiments in yeast and followed the long-term dynamics of aneuploidy under diverse conditions. Here we show that chromosomal duplications are first acquired as a crude solution to stress, yet only as transient solutions that are eliminated and replaced by more efficient solutions obtained at the individual gene level. These transient dynamics of aneuploidy were repeatedly observed in our laboratory evolution experiments; chromosomal duplications gained under stress were eliminated not only when the stress was relieved, but even if it persisted. Furthermore, when stress was applied gradually rather than abruptly, alternative solutions appear to have emerged, but not aneuploidy. Our findings indicate that chromosomal duplication is a first evolutionary line of defense, that retains survivability under strong and abrupt selective pressures, yet it merely serves as a “quick fix,” whereas more refined and sustainable solutions take over. Thus, in the perspective of genome evolution trajectory, aneuploidy is a useful yet short-lived intermediate that facilitates further adaptation.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380857613126358017","@type":"Researcher","foaf:name":[{"@value":"Avihu H. Yona"}],"jpcoar:affiliationName":[{"@value":"Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100 Israel; and"}]},{"@id":"https://cir.nii.ac.jp/crid/1380857613126358018","@type":"Researcher","foaf:name":[{"@value":"Yair S. Manor"}],"jpcoar:affiliationName":[{"@value":"Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100 Israel; and"}]},{"@id":"https://cir.nii.ac.jp/crid/1380857613126358022","@type":"Researcher","foaf:name":[{"@value":"Rebecca H. Herbst"}],"jpcoar:affiliationName":[{"@value":"Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100 Israel; and"}]},{"@id":"https://cir.nii.ac.jp/crid/1380857613126358019","@type":"Researcher","foaf:name":[{"@value":"Gal H. Romano"}],"jpcoar:affiliationName":[{"@value":"Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Tel-Aviv 39040, Israel"}]},{"@id":"https://cir.nii.ac.jp/crid/1380857613126358016","@type":"Researcher","foaf:name":[{"@value":"Amir Mitchell"}],"jpcoar:affiliationName":[{"@value":"Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100 Israel; and"}]},{"@id":"https://cir.nii.ac.jp/crid/1380857613126358021","@type":"Researcher","foaf:name":[{"@value":"Martin Kupiec"}],"jpcoar:affiliationName":[{"@value":"Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Tel-Aviv 39040, Israel"}]},{"@id":"https://cir.nii.ac.jp/crid/1380857613126358023","@type":"Researcher","foaf:name":[{"@value":"Yitzhak Pilpel"}],"jpcoar:affiliationName":[{"@value":"Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100 Israel; and"}]},{"@id":"https://cir.nii.ac.jp/crid/1380857613126358020","@type":"Researcher","foaf:name":[{"@value":"Orna Dahan"}],"jpcoar:affiliationName":[{"@value":"Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100 Israel; and"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00278424"},{"@type":"EISSN","@value":"10916490"}],"prism:publicationName":[{"@value":"Proceedings of the National Academy of Sciences"}],"dc:publisher":[{"@value":"Proceedings of the National Academy of Sciences"}],"prism:publicationDate":"2012-11-29","prism:volume":"109","prism:number":"51","prism:startingPage":"21010","prism:endingPage":"21015"},"reviewed":"false","url":[{"@id":"https://pnas.org/doi/pdf/10.1073/pnas.1211150109"}],"createdAt":"2012-11-30","modifiedAt":"2022-06-07","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360285712918018560","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Large-Scale Survey of Intraspecific Fitness and Cell Morphology Variation in a Protoploid Yeast Species"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848662872406784","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Comprehensive Analysis of the <i>SUL1</i> Promoter of <i>Saccharomyces cerevisiae</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1360861704780957952","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Diploid-associated adaptation to chronic low-dose UV irradiation requires homologous recombination in <i>Saccharomyces cerevisiae</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1390303932782099712","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"三重県清酒酵母の遺伝的及び醸造特性の包括的評価"},{"@language":"en","@value":"Comprehensive genetic and brewing characterization of Mie sake yeast strains"},{"@language":"ja-Kana","@value":"ミエケン セイシュ コウボ ノ イデンテキ オヨビ ジョウゾウ トクセイ ノ ホウカツテキ ヒョウカ"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1073/pnas.1211150109"},{"@type":"CROSSREF","@value":"10.6013/jbrewsocjapan.118.115_references_DOI_MCi2PpYZnvENntPBNAPQGiDmk4i"},{"@type":"CROSSREF","@value":"10.1534/g3.115.026682_references_DOI_MCi2PpYZnvENntPBNAPQGiDmk4i"},{"@type":"CROSSREF","@value":"10.1534/genetics.116.188037_references_DOI_MCi2PpYZnvENntPBNAPQGiDmk4i"},{"@type":"CROSSREF","@value":"10.1093/genetics/iyac115_references_DOI_MCi2PpYZnvENntPBNAPQGiDmk4i"}]}