Prevalence and Genetic Diversity of Aichi Virus Strains in Stool Samples from Community and Hospitalized Patients

DOI Web Site 12 Citations
  • K. Ambert-Balay
    Laboratoire de Virologie, Reference Laboratory for Enteric Viruses, Centre Hospitalier Universitaire, and UFRs Médecine et Pharmacie, Dijon
  • M. Lorrot
    Service de Pédiatrie, Centre Hospitalier Saint Vincent de Paul, Paris
  • F. Bon
    Laboratoire de Virologie, Reference Laboratory for Enteric Viruses, Centre Hospitalier Universitaire, and UFRs Médecine et Pharmacie, Dijon
  • H. Giraudon
    Laboratoire de Virologie, Reference Laboratory for Enteric Viruses, Centre Hospitalier Universitaire, and UFRs Médecine et Pharmacie, Dijon
  • J. Kaplon
    Laboratoire de Virologie, Reference Laboratory for Enteric Viruses, Centre Hospitalier Universitaire, and UFRs Médecine et Pharmacie, Dijon
  • M. Wolfer
    Service de Pédiatrie, Centre Hospitalier Saint Vincent de Paul, Paris
  • P. Lebon
    Laboratoire de Virologie, Centre Hospitalier Saint Vincent de Paul, Paris, France
  • D. Gendrel
    Service de Pédiatrie, Centre Hospitalier Saint Vincent de Paul, Paris
  • P. Pothier
    Laboratoire de Virologie, Reference Laboratory for Enteric Viruses, Centre Hospitalier Universitaire, and UFRs Médecine et Pharmacie, Dijon

Bibliographic Information

Published
2008-04
Rights Information
  • https://journals.asm.org/non-commercial-tdm-license
DOI
  • 10.1128/jcm.02140-07
Publisher
American Society for Microbiology

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<jats:title>ABSTRACT</jats:title><jats:p>Aichi virus has been proposed as a causative agent of gastroenteritis. A total of 457 stool specimens from children hospitalized with acute diarrhea and 566 stool specimens from adults and children involved in 110 gastroenteritis outbreaks were screened for the presence of Aichi virus by reverse transcription-PCR (RT-PCR) amplification of the genomic region of the 3C and 3D (3CD) nonstructural proteins. Our results show a low incidence of Aichi virus in pediatric samples and the existence of mixed infections with other microbiological agents in some cases. From the outbreak survey, it appears that the presence of Aichi virus is an indicator of mixed infections causing gastroenteritis outbreaks and that it could be involved in half of the oyster-associated outbreaks. A second RT-PCR was developed to amplify a part of the VP1 gene. The phylogenetic analysis showed a good correlation between the two classifications based on 3CD and VP1 gene sequences and revealed the prevalence of genotype A in France. It also allowed us to partially describe an Aichi virus strain that could represent a new genotype, thus suggesting the existence of a certain diversity.</jats:p>

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