{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362262946092284672.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.3390/ijms19123871"}},{"identifier":{"@type":"URI","@value":"https://www.mdpi.com/1422-0067/19/12/3871/pdf"}}],"dc:title":[{"@value":"Perturbing the Dynamics and Organization of Cell Membrane Components: A New Paradigm for Cancer-Targeted Therapies"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Cancer is a multi-process disease where different mechanisms exist in parallel to ensure cell survival and constant adaptation to the extracellular environment. To adapt rapidly, cancer cells re-arrange their plasma membranes to sustain proliferation, avoid apoptosis and resist anticancer drugs. In this review, we discuss novel approaches based on the modifications and manipulations that new classes of molecules can exert in the plasma membrane lateral organization and order of cancer cells, affecting growth factor signaling, invasiveness, and drug resistance. Furthermore, we present azurin, an anticancer protein from bacterial origin, as a new approach in the development of therapeutic strategies that target the cell membrane to improve the existing standard therapies.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382262946092284672","@type":"Researcher","foaf:name":[{"@value":"Nuno Bernardes"}],"jpcoar:affiliationName":[{"@value":"iBB-Institute for Bioengineering and Biosciences, Biological Sciences Research Group, Av. Rovisco Pais 1, 1049-001 Lisbon, Portugal"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262946092284673","@type":"Researcher","foaf:name":[{"@value":"Arsenio Fialho"}],"jpcoar:affiliationName":[{"@value":"iBB-Institute for Bioengineering and Biosciences, Biological Sciences Research Group, Av. Rovisco Pais 1, 1049-001 Lisbon, Portugal"},{"@value":"Department of Bioengineering, Instituto Superior Técnico, University of Lisbon, 1049-001 Lisbon, Portugal"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"14220067"}],"prism:publicationName":[{"@value":"International Journal of Molecular Sciences"}],"dc:publisher":[{"@value":"MDPI AG"}],"prism:publicationDate":"2018-12-04","prism:volume":"19","prism:number":"12","prism:startingPage":"3871"},"reviewed":"false","dc:rights":["https://creativecommons.org/licenses/by/4.0/"],"url":[{"@id":"https://www.mdpi.com/1422-0067/19/12/3871/pdf"}],"createdAt":"2018-12-04","modifiedAt":"2025-10-11","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360290617744072320","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Gold-Etched Silver Nanowire Endoscopy: Toward a Widely Accessible Platform for Surface-Enhanced Raman Scattering-Based Analysis in Living Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298757455363072","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Oxidative Stress Pathways Linked to Apoptosis Induction by Low-Temperature Plasma Jet Activated Media in Bladder Cancer Cells: An In Vitro and In Vivo Study"}]},{"@id":"https://cir.nii.ac.jp/crid/1360584339750489344","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"A silica-based antioxidant nanoparticle for oral delivery of Camptothecin which reduces intestinal side effects while improving drug efficacy for colon cancer treatment"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420900240256","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The lipid composition affects Trastuzumab adsorption at monolayers at the air-water interface"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.3390/ijms19123871"},{"@type":"CROSSREF","@value":"10.1021/acs.analchem.0c04120_references_DOI_J5EXWAFPHgMAkL3cMHJecOyuAp1"},{"@type":"CROSSREF","@value":"10.3390/plasma5020018_references_DOI_J5EXWAFPHgMAkL3cMHJecOyuAp1"},{"@type":"CROSSREF","@value":"10.1016/j.chemphyslip.2020.104875_references_DOI_J5EXWAFPHgMAkL3cMHJecOyuAp1"},{"@type":"CROSSREF","@value":"10.1016/j.actbio.2022.02.036_references_DOI_J5EXWAFPHgMAkL3cMHJecOyuAp1"}]}