{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362262946167490688.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1038/s41598-018-29808-6"}},{"identifier":{"@type":"URI","@value":"https://www.nature.com/articles/s41598-018-29808-6.pdf"}},{"identifier":{"@type":"URI","@value":"https://www.nature.com/articles/s41598-018-29808-6"}},{"identifier":{"@type":"PMID","@value":"30068907"}}],"dc:title":[{"@value":"A sarcopenia index based on serum creatinine and cystatin C cannot accurately detect either low muscle mass or sarcopenia in urban community-dwelling older people"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:p>The aim of this study was to evaluate the diagnostic value of the sarcopenia index (serum creatinine [mg/dl]/cystatin C [mg/dl] × 100) for estimating low muscle mass and sarcopenia in community-dwelling older adults. We included 371 older adults (≥60 years) with normal kidney function. Four common diagnostic criteria (the European Working Group on Sarcopenia in Older People (EWGSOP), Asia Working Group for Sarcopenia (AWGS), International Working Group on Sarcopenia (IWGS), and Foundation for the National Institutes of Health (FNIH) criteria) were separately applied as the “gold standard”. The receiver operating characteristic (ROC) curves and the area under the ROC curves (AUC) were applied to evaluate the overall diagnostic accuracy. For identifying low muscle mass, the AUC ranged from 0.505 (95% confidence interval [CI] 0.453–0.557) to 0.558 (95% CI 0.506–0.609). For identifying sarcopenia, the AUC ranged from 0.555 (95% CI 0.503–0.606) to 0.618 (95% CI 0.566–0.668). Subgroup analyses according to gender showed similar results. In conclusion, the sarcopenia index based on serum creatinine and cystatin C may not serve as biomarkers of either low muscle mass or sarcopenia in urban community-dwelling older people with normal kidney function.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382262946167490689","@type":"Researcher","foaf:name":[{"@value":"Qian He"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262946167490690","@type":"Researcher","foaf:name":[{"@value":"Jiaojiao Jiang"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262946167490692","@type":"Researcher","foaf:name":[{"@value":"Lingling Xie"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262946167490688","@type":"Researcher","foaf:name":[{"@value":"Luoying Zhang"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262946167490691","@type":"Researcher","foaf:name":[{"@value":"Ming Yang"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"20452322"}],"prism:publicationName":[{"@value":"Scientific Reports"}],"dc:publisher":[{"@value":"Springer Science and Business Media LLC"}],"prism:publicationDate":"2018-08-01","prism:volume":"8","prism:number":"1","prism:startingPage":"11534"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://creativecommons.org/licenses/by/4.0","https://creativecommons.org/licenses/by/4.0"],"url":[{"@id":"https://www.nature.com/articles/s41598-018-29808-6.pdf"},{"@id":"https://www.nature.com/articles/s41598-018-29808-6"}],"createdAt":"2018-07-26","modifiedAt":"2022-12-21","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Aged,%2080%20and%20over","dc:title":"Aged, 80 and over"},{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Serum","dc:title":"Serum"},{"@id":"https://cir.nii.ac.jp/all?q=China","dc:title":"China"},{"@id":"https://cir.nii.ac.jp/all?q=Sarcopenia","dc:title":"Sarcopenia"},{"@id":"https://cir.nii.ac.jp/all?q=Urban%20Population","dc:title":"Urban Population"},{"@id":"https://cir.nii.ac.jp/all?q=Diagnostic%20Tests,%20Routine","dc:title":"Diagnostic Tests, Routine"},{"@id":"https://cir.nii.ac.jp/all?q=Middle%20Aged","dc:title":"Middle Aged"},{"@id":"https://cir.nii.ac.jp/all?q=Article","dc:title":"Article"},{"@id":"https://cir.nii.ac.jp/all?q=ROC%20Curve","dc:title":"ROC Curve"},{"@id":"https://cir.nii.ac.jp/all?q=Creatinine","dc:title":"Creatinine"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Female","dc:title":"Female"},{"@id":"https://cir.nii.ac.jp/all?q=Cystatin%20C","dc:title":"Cystatin C"},{"@id":"https://cir.nii.ac.jp/all?q=Aged","dc:title":"Aged"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360025430196240640","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Oral Frailty and Its Relationship with Physical Frailty in Older Adults: A Longitudinal Study Using the Oral Frailty Five-Item Checklist"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298757422544640","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Association between oral frailty and cystatin C-related indices—A questionnaire (OFI-8) study in general internal medicine practice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360302864784316160","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Serum Creatinine–Cystatin C Based Screening of Sarcopenia in Community Dwelling Older Adults: A Cross-Sectional Analysis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360857593748459904","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Estimation of Muscle Mass Using Creatinine/Cystatin C Ratio in Japanese Community-Dwelling Older People"}]},{"@id":"https://cir.nii.ac.jp/crid/2050588892104605312","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Relationships between cystatin C- and creatinine-based eGFR in Japanese rural community- dwelling older adults with sarcopenia"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1038/s41598-018-29808-6"},{"@type":"OPENAIRE","@value":"doi_dedup___::0f6a619e854d971b9ad56957c636c3b1"},{"@type":"CROSSREF","@value":"10.3390/nu17010017_references_DOI_S8Rhrvz9QdeReMAVq0bXjYSIGl3"},{"@type":"CROSSREF","@value":"10.1371/journal.pone.0283803_references_DOI_S8Rhrvz9QdeReMAVq0bXjYSIGl3"},{"@type":"CROSSREF","@value":"10.1007/s10157-020-01981-x_references_DOI_S8Rhrvz9QdeReMAVq0bXjYSIGl3"},{"@type":"CROSSREF","@value":"10.1016/j.jamda.2021.07.029_references_DOI_S8Rhrvz9QdeReMAVq0bXjYSIGl3"},{"@type":"CROSSREF","@value":"10.14283/jfa.2024.13_references_DOI_S8Rhrvz9QdeReMAVq0bXjYSIGl3"}]}