{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362262946286708352.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1038/365340a0"}},{"identifier":{"@type":"URI","@value":"http://www.nature.com/articles/365340a0"}},{"identifier":{"@type":"URI","@value":"http://www.nature.com/articles/365340a0.pdf"}},{"identifier":{"@type":"PMID","@value":"7690905"}},{"identifier":{"@type":"NAID","@value":"80007261070"}}],"dc:title":[{"@value":"Induction of human IgE synthesis in B cells by mast cells and basophils"}],"description":[{"notation":[{"@value":"Immunoglobulin E (IgE) is central to the induction of allergic diseases through its binding to the high-affinity receptor (Fc epsilon R1) on mast cells and basophils. Crosslinking by allergens of the bound IgE leads to the release of various inflammatory mediators. IgE production by B cells requires a physical interaction with T cells, involving a number of surface adhesion molecules, as well as the soluble factors interleukin-4 (IL-4) and IL-13 (ref. 5) produced by T cells, basophils and mast cells. Here we report that, in the presence of IL-4, mast and basophilic cell lines can provide the cell contact signals that are required for IgE synthesis. The human cell lines HMC-1 (mast) and KU812 (basophilic) both express the ligand for CD40 (CD40L) which is shown to be responsible for the IgE production. Moreover, freshly isolated purified human lung mast cells and blood basophils are also shown to express CD40L and to induce IgE production. This evidence suggests that mast cells and basophils may therefore play a key role in allergy not only by producing inflammatory mediators, but also by directly regulating IgE production independently of T cells."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382262946286708357","@type":"Researcher","foaf:name":[{"@value":"Jean-François Gauchat"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262946286708483","@type":"Researcher","foaf:name":[{"@value":"Sybille Henchoz"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262946286708359","@type":"Researcher","foaf:name":[{"@value":"Gonzalo Mazzei"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262946286708358","@type":"Researcher","foaf:name":[{"@value":"Jean-Pierre Aubry"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262946286708356","@type":"Researcher","foaf:name":[{"@value":"Thomas Brunner"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262946286708481","@type":"Researcher","foaf:name":[{"@value":"Horst Blasey"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262946286708361","@type":"Researcher","foaf:name":[{"@value":"Paul Life"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262946286708482","@type":"Researcher","foaf:name":[{"@value":"Dominique Talabot"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262946286708352","@type":"Researcher","foaf:name":[{"@value":"Leopoldo Flores-Romo"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262946286708360","@type":"Researcher","foaf:name":[{"@value":"Jeff Thompson"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262946286708354","@type":"Researcher","foaf:name":[{"@value":"Kenji Kishi"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262946286708480","@type":"Researcher","foaf:name":[{"@value":"Joseph Butterfield"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262946286708355","@type":"Researcher","foaf:name":[{"@value":"Clemens Dahinden"}]},{"@id":"https://cir.nii.ac.jp/crid/1382262946286708353","@type":"Researcher","foaf:name":[{"@value":"Jean-Yves Bonnefoy"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00280836"},{"@type":"EISSN","@value":"14764687"}],"prism:publicationName":[{"@value":"Nature"}],"dc:publisher":[{"@value":"Springer Science and Business Media LLC"}],"prism:publicationDate":"1993-09","prism:volume":"365","prism:number":"6444","prism:startingPage":"340","prism:endingPage":"343"},"reviewed":"false","dc:rights":["http://www.springer.com/tdm"],"url":[{"@id":"http://www.nature.com/articles/365340a0"},{"@id":"http://www.nature.com/articles/365340a0.pdf"}],"createdAt":"2003-08-12","modifiedAt":"2023-05-17","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=T-Lymphocytes","dc:title":"T-Lymphocytes"},{"@id":"https://cir.nii.ac.jp/all?q=CD40%20Ligand","dc:title":"CD40 Ligand"},{"@id":"https://cir.nii.ac.jp/all?q=Molecular%20Sequence%20Data","dc:title":"Molecular Sequence Data"},{"@id":"https://cir.nii.ac.jp/all?q=Palatine%20Tonsil","dc:title":"Palatine Tonsil"},{"@id":"https://cir.nii.ac.jp/all?q=DNA,%20Single-Stranded","dc:title":"DNA, Single-Stranded"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Communication","dc:title":"Cell Communication"},{"@id":"https://cir.nii.ac.jp/all?q=Ligands","dc:title":"Ligands"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Line","dc:title":"Cell Line"},{"@id":"https://cir.nii.ac.jp/all?q=Antigens,%20CD","dc:title":"Antigens, CD"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Mast%20Cells","dc:title":"Mast Cells"},{"@id":"https://cir.nii.ac.jp/all?q=CD40%20Antigens","dc:title":"CD40 Antigens"},{"@id":"https://cir.nii.ac.jp/all?q=Lung","dc:title":"Lung"},{"@id":"https://cir.nii.ac.jp/all?q=Skin","dc:title":"Skin"},{"@id":"https://cir.nii.ac.jp/all?q=B-Lymphocytes","dc:title":"B-Lymphocytes"},{"@id":"https://cir.nii.ac.jp/all?q=Membrane%20Glycoproteins","dc:title":"Membrane Glycoproteins"},{"@id":"https://cir.nii.ac.jp/all?q=Base%20Sequence","dc:title":"Base Sequence"},{"@id":"https://cir.nii.ac.jp/all?q=Immunoglobulin%20E","dc:title":"Immunoglobulin E"},{"@id":"https://cir.nii.ac.jp/all?q=Basophils","dc:title":"Basophils"},{"@id":"https://cir.nii.ac.jp/all?q=Antigens,%20Differentiation,%20B-Lymphocyte","dc:title":"Antigens, Differentiation, B-Lymphocyte"},{"@id":"https://cir.nii.ac.jp/all?q=Blood","dc:title":"Blood"},{"@id":"https://cir.nii.ac.jp/all?q=Cyclosporine","dc:title":"Cyclosporine"},{"@id":"https://cir.nii.ac.jp/all?q=Interleukin-4","dc:title":"Interleukin-4"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050282677702094848","@type":"Article","resourceType":"紀要論文(departmental bulletin paper)","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@value":"アレルギー疾患にみられる好酸球活性化・好塩基球IgE結合状態のフローサイトメトリー法による臨床的評価(II)　アレルギー疾患における末梢血好塩基球IgE結合状態とその臨床的意義"}]},{"@id":"https://cir.nii.ac.jp/crid/1360021391876841216","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Editorial: The fundamental biology of basophils in health and disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285707523774848","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Basophils help establish protective immunity induced by irradiated larval vaccination for filariasis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565168590907904","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Nonredundant Roles of Basophils in Immunity"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846640794760064","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Potentiation of TLR9 responses for human naïve B-cell growth through RP105 signaling"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848658341952896","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"IL-21 Reduces Immediate Hypersensitivity Reactions in Mouse Skin by Suppressing Mast Cell Activation or IgE Production"}]},{"@id":"https://cir.nii.ac.jp/crid/1360857593781939072","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The role of Sp140 revealed in IgE and mast cell responses in Collaborative Cross mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205740314496","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"アトピー性皮膚炎モデルマウスのマスト細胞におけるIL-3およびIL-4に対する増殖活性に関する検討"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679247861888","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"アレルギー性炎症治療戦略の最前線　　基礎から臨床まで　　３　　アレルギー性炎症における肥満細胞の役割―肥満細胞の引き起こす炎症を自然免疫の観点から考える―"},{"@language":"en","@value":"The role of mast cells in allergic inflammation"},{"@value":"アレルギー性炎症における肥満細胞の役割--肥満細胞の引き起こす炎症を自然免疫の観点から考える"},{"@language":"ja-Kana","@value":"アレルギーセイ エンショウ ニ オケル ヒマン サイボウ ノ ヤクワリ ヒマン サイボウ ノ ヒキオコス エンショウ オ シゼン メンエキ ノ カンテン カラ カンガエル"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679275108480","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Atopic dermatitis/keyword and the approach (1).  IgE antibody and atopic dermatitis."},{"@language":"ja","@value":"アトピー性皮膚炎・キーワードとその考え方（１）　　ＩｇＥ抗体とアトピー性皮膚炎"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679435412608","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Inhibitory Effects of Traditional Okinawan Vegetable Methanol Extracts and Their Primary Constituents on Histamine Release from Human Basophilic KU812 cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679608747904","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Mast cell function modulating IgE-mediated allergy."}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679609265408","@type":"Article","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Basophils: A Potential Liaison between Innate and Adaptive Immunity"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679610046976","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Flavonoids and Related Compounds as Anti-Allergic Substances"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679610987648","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Molecular regulation of human IgE synthesis."}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679754547584","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Drug Allergy and Histamine. A Study on the Allergic Response to the Carboxymethylcellulose Sodium in Barium Meal."},{"@value":"医薬品アレルギーとヒスタミン　　医薬品添加物カルボキシメチルセルロースナトリウムによるアレルギー反応に関する研究"},{"@language":"ja-Kana","@value":"イヤクヒン アレルギー ト ヒスタミン イヤクヒン テンカブツ カルボキシメチル セルロース ナトリウム ニヨル アレルギー ハンノウ ニ カンスル ケンキュウ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679957798400","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"気管支喘息患者における気道粘膜へのアゼラスチンの作用 : 特にサイトカインmRNAの発現の抑制について"},{"@language":"en","@value":"THE EFFECT OF AZELASTINE ON BRONCHIAL MUCOSA IN BRONCHIAL ASTHMA : Suppression of Cytokine mRNA"}]},{"@id":"https://cir.nii.ac.jp/crid/1390578160855081728","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Chronic urticaria and the pathogenic role of mast cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1570291224434511872","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"CD40 expressed on human melanoma cells mediates T cell co-stimulation and tumor cell growth"}]},{"@id":"https://cir.nii.ac.jp/crid/1570291224985503232","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"アトピー性皮膚炎患者におけるTh1-Th2バランス制御機構の解析"}]},{"@id":"https://cir.nii.ac.jp/crid/1570572699769100160","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Molecular regulation of human IgE synthesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1571698599647585664","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"アトピー性皮膚炎の炎症抑制"},{"@language":"en","@value":"Control of inflammation in atopic dermatitis"}]},{"@id":"https://cir.nii.ac.jp/crid/1571980075455676672","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Mucosal immunology of the upper airway : Reassessing the role of mast cells and T cells in the pathogenesis of allergic rhinitis"}]},{"@id":"https://cir.nii.ac.jp/crid/1572261549251894272","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"IL-4 production by allergen-stimulated primary cultures: identification of basophils as the major IL-4-producing cell type"}]},{"@id":"https://cir.nii.ac.jp/crid/1572543024532726272","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"CD40-mediated signaling in monocytic cells: up-regulation of tumor necrosis factor receptor-associated factor mRNAs and activation of mitogen-activated protein kinase signaling pathways"}]},{"@id":"https://cir.nii.ac.jp/crid/1572543024606140800","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Mast cell function modulating IgE-mediated allergy"}]},{"@id":"https://cir.nii.ac.jp/crid/1572824499776046976","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"サイトカインのレギュレーション"}]},{"@id":"https://cir.nii.ac.jp/crid/1572824500442463616","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"IL-33 amplifies both T_h1-and T_h2-type responses through its activity on human basophils, allergen-reactive T_h2 cells, iNKT and NK Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1573105975288782464","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"アトピー性皮膚炎・キーワードとその考え方(1) : IgE抗体とアトピー性皮膚炎"}]},{"@id":"https://cir.nii.ac.jp/crid/1573668924706112896","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"高親和性IgEレセプター(FcεRI)とI型アレルギー"}]},{"@id":"https://cir.nii.ac.jp/crid/1574231874970050048","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Analyzing the Roles of Mast Cells and Basophils in Host Defense and Other Biological Responses"}]},{"@id":"https://cir.nii.ac.jp/crid/1574231875757462528","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"ヒトB細胞におけるクラススイッチング"},{"@language":"en","@value":"Class Switching on Human B cell"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1038/365340a0"},{"@type":"CIA","@value":"80007261070"},{"@type":"OPENAIRE","@value":"doi_dedup___::cd9bb3f81381c1edf9cdeaa5bd571aef"},{"@type":"CROSSREF","@value":"10.1146/annurev-immunol-031210-101257_references_DOI_BTB7f7LhC4YWUKpuIKw97XhoDEc"},{"@type":"CROSSREF","@value":"10.3389/fimmu.2023.1292279_references_DOI_BTB7f7LhC4YWUKpuIKw97XhoDEc"},{"@type":"CROSSREF","@value":"10.2332/allergolint.r-06-135_references_DOI_BTB7f7LhC4YWUKpuIKw97XhoDEc"},{"@type":"CROSSREF","@value":"10.1046/j.1440-1592.1999.00138.x_references_DOI_BTB7f7LhC4YWUKpuIKw97XhoDEc"},{"@type":"CROSSREF","@value":"10.1038/jid.2011.73_references_DOI_BTB7f7LhC4YWUKpuIKw97XhoDEc"},{"@type":"CROSSREF","@value":"10.2336/nishinihonhifu.60.514_references_DOI_BTB7f7LhC4YWUKpuIKw97XhoDEc"},{"@type":"CROSSREF","@value":"10.1254/fpj.125.259_references_DOI_BTB7f7LhC4YWUKpuIKw97XhoDEc"},{"@type":"CROSSREF","@value":"10.1172/jci.insight.146572_references_DOI_BTB7f7LhC4YWUKpuIKw97XhoDEc"},{"@type":"CROSSREF","@value":"10.1016/j.alit.2023.05.003_references_DOI_BTB7f7LhC4YWUKpuIKw97XhoDEc"},{"@type":"CROSSREF","@value":"10.1016/j.clim.2009.12.013_references_DOI_BTB7f7LhC4YWUKpuIKw97XhoDEc"},{"@type":"CROSSREF","@value":"10.3136/fstr.24.321_references_DOI_BTB7f7LhC4YWUKpuIKw97XhoDEc"},{"@type":"CROSSREF","@value":"10.1046/j.1440-1592.1999.00124.x_references_DOI_BTB7f7LhC4YWUKpuIKw97XhoDEc"},{"@type":"CROSSREF","@value":"10.1016/j.vaccine.2013.06.010_references_DOI_BTB7f7LhC4YWUKpuIKw97XhoDEc"},{"@type":"CROSSREF","@value":"10.2332/allergolint.55.99_references_DOI_BTB7f7LhC4YWUKpuIKw97XhoDEc"}]}