{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362262946333343616.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1158/2159-8290.cd-18-1522"}},{"identifier":{"@type":"URI","@value":"https://aacrjournals.org/cancerdiscovery/article-pdf/9/7/852/1846147/852.pdf"}}],"dc:title":[{"@value":"Oral Mucosal Organoids as a Potential Platform for Personalized Cancer Therapy"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title>\n                  <jats:sec>\n                    <jats:title/>\n                    <jats:p>Previous studies have described that tumor organoids can capture the diversity of defined human carcinoma types. Here, we describe conditions for long-term culture of human mucosal organoids. Using this protocol, a panel of 31 head and neck squamous cell carcinoma (HNSCC)–derived organoid lines was established. This panel recapitulates genetic and molecular characteristics previously described for HNSCC. Organoids retain their tumorigenic potential upon xenotransplantation. We observe differential responses to a panel of drugs including cisplatin, carboplatin, cetuximab, and radiotherapy in vitro. Additionally, drug screens reveal selective sensitivity to targeted drugs that are not normally used in the treatment of patients with HNSCC. These observations may inspire a personalized approach to the management of HNSCC and expand the repertoire of HNSCC drugs.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance:</jats:title>\n                    <jats:p>This work describes the culture of organoids derived from HNSCC and corresponding normal epithelium. These tumoroids recapitulate the disease genetically, histologically, and functionally. In vitro drug screening of tumoroids reveals responses to therapies both currently used in the treatment of HNSCC and those not (yet) used in clinical practice.</jats:p>\n                    <jats:p>See related commentary by Hill and D'Andrea, p. 828.</jats:p>\n                    <jats:p>This article is highlighted in the In This Issue feature, p. 813</jats:p>\n                  </jats:sec>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382262946333343619","@type":"Researcher","foaf:name":[{"@value":"Else Driehuis"}],"jpcoar:affiliationName":[{"@value":"1Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, Utrecht, the Netherlands."}]},{"@id":"https://cir.nii.ac.jp/crid/1382262946333343750","@type":"Researcher","foaf:name":[{"@value":"Sigrid Kolders"}],"jpcoar:affiliationName":[{"@value":"1Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, Utrecht, the Netherlands."}]},{"@id":"https://cir.nii.ac.jp/crid/1382262946333343746","@type":"Researcher","foaf:name":[{"@value":"Sacha Spelier"}],"jpcoar:affiliationName":[{"@value":"1Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, Utrecht, the Netherlands."}]},{"@id":"https://cir.nii.ac.jp/crid/1382262946333343621","@type":"Researcher","foaf:name":[{"@value":"Kadi Lõhmussaar"}],"jpcoar:affiliationName":[{"@value":"1Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, Utrecht, the Netherlands."}]},{"@id":"https://cir.nii.ac.jp/crid/1382262946333343625","@type":"Researcher","foaf:name":[{"@value":"Stefan M. Willems"}],"jpcoar:affiliationName":[{"@value":"2Department of Pathology, University Medical Center Utrecht, Utrecht, the Netherlands."}]},{"@id":"https://cir.nii.ac.jp/crid/1382262946333343618","@type":"Researcher","foaf:name":[{"@value":"Lot A. Devriese"}],"jpcoar:affiliationName":[{"@value":"3Department of Medical Oncology, University Medical Center Utrecht, Utrecht, the Netherlands."}]},{"@id":"https://cir.nii.ac.jp/crid/1382262946333343744","@type":"Researcher","foaf:name":[{"@value":"Remco de Bree"}],"jpcoar:affiliationName":[{"@value":"4Department of Head and Neck Surgical Oncology, University Medical Center Utrecht, Utrecht, the Netherlands."}]},{"@id":"https://cir.nii.ac.jp/crid/1382262946333343747","@type":"Researcher","foaf:name":[{"@value":"Emma J. de Ruiter"}],"jpcoar:affiliationName":[{"@value":"2Department of Pathology, University Medical Center Utrecht, Utrecht, the Netherlands."}]},{"@id":"https://cir.nii.ac.jp/crid/1382262946333343620","@type":"Researcher","foaf:name":[{"@value":"Jeroen Korving"}],"jpcoar:affiliationName":[{"@value":"1Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, Utrecht, the Netherlands."}]},{"@id":"https://cir.nii.ac.jp/crid/1382262946333343751","@type":"Researcher","foaf:name":[{"@value":"Harry Begthel"}],"jpcoar:affiliationName":[{"@value":"1Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, Utrecht, the Netherlands."}]},{"@id":"https://cir.nii.ac.jp/crid/1382262946333343626","@type":"Researcher","foaf:name":[{"@value":"Johan H. van Es"}],"jpcoar:affiliationName":[{"@value":"1Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, Utrecht, the Netherlands."}]},{"@id":"https://cir.nii.ac.jp/crid/1382262946333343616","@type":"Researcher","foaf:name":[{"@value":"Veerle Geurts"}],"jpcoar:affiliationName":[{"@value":"1Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, Utrecht, the Netherlands."}]},{"@id":"https://cir.nii.ac.jp/crid/1382262946333343623","@type":"Researcher","foaf:name":[{"@value":"Gui-Wei He"}],"jpcoar:affiliationName":[{"@value":"1Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, Utrecht, the Netherlands."}]},{"@id":"https://cir.nii.ac.jp/crid/1382262946333343754","@type":"Researcher","foaf:name":[{"@value":"Richard H. van Jaarsveld"}],"jpcoar:affiliationName":[{"@value":"1Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, Utrecht, the Netherlands."}]},{"@id":"https://cir.nii.ac.jp/crid/1382262946333343755","@type":"Researcher","foaf:name":[{"@value":"Rurika Oka"}],"jpcoar:affiliationName":[{"@value":"5Princess Maxima Center, Utrecht, the Netherlands."}]},{"@id":"https://cir.nii.ac.jp/crid/1382262946333343753","@type":"Researcher","foaf:name":[{"@value":"Mauro J. Muraro"}],"jpcoar:affiliationName":[{"@value":"1Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, Utrecht, the Netherlands."},{"@value":"6Single Cell Discoveries, Utrecht, the Netherlands."}]},{"@id":"https://cir.nii.ac.jp/crid/1382262946333343628","@type":"Researcher","foaf:name":[{"@value":"Judith Vivié"}],"jpcoar:affiliationName":[{"@value":"1Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, Utrecht, the Netherlands."},{"@value":"6Single Cell Discoveries, Utrecht, the Netherlands."}]},{"@id":"https://cir.nii.ac.jp/crid/1382262946333343617","@type":"Researcher","foaf:name":[{"@value":"Maurice M.J.M. Zandvliet"}],"jpcoar:affiliationName":[{"@value":"7Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, the Netherlands."}]},{"@id":"https://cir.nii.ac.jp/crid/1382262946333343749","@type":"Researcher","foaf:name":[{"@value":"Antoni P.A. Hendrickx"}],"jpcoar:affiliationName":[{"@value":"8Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, the Netherlands."}]},{"@id":"https://cir.nii.ac.jp/crid/1382262946333343748","@type":"Researcher","foaf:name":[{"@value":"Nino Iakobachvili"}],"jpcoar:affiliationName":[{"@value":"9M4I Division of Nanoscopy, Maastricht University, Maastricht, the Netherlands."}]},{"@id":"https://cir.nii.ac.jp/crid/1382262946333343758","@type":"Researcher","foaf:name":[{"@value":"Priya Sridevi"}],"jpcoar:affiliationName":[{"@value":"10Cold Spring Harbor Laboratory, Cold Spring Harbor, New York."}]},{"@id":"https://cir.nii.ac.jp/crid/1382262946333343624","@type":"Researcher","foaf:name":[{"@value":"Onno Kranenburg"}],"jpcoar:affiliationName":[{"@value":"11Utrecht Platform for Organoid Technology (U-PORT), Utrecht Medical Center Utrecht, Utrecht, the Netherlands."}]},{"@id":"https://cir.nii.ac.jp/crid/1382262946333343752","@type":"Researcher","foaf:name":[{"@value":"Ruben van Boxtel"}],"jpcoar:affiliationName":[{"@value":"5Princess Maxima Center, Utrecht, the Netherlands."}]},{"@id":"https://cir.nii.ac.jp/crid/1382262946333343622","@type":"Researcher","foaf:name":[{"@value":"Geert J.P.L. Kops"}],"jpcoar:affiliationName":[{"@value":"1Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, Utrecht, the Netherlands."}]},{"@id":"https://cir.nii.ac.jp/crid/1382262946333343756","@type":"Researcher","foaf:name":[{"@value":"David A. Tuveson"}],"jpcoar:affiliationName":[{"@value":"10Cold Spring Harbor Laboratory, Cold Spring Harbor, New York."}]},{"@id":"https://cir.nii.ac.jp/crid/1382262946333343757","@type":"Researcher","foaf:name":[{"@value":"Peter J. Peters"}],"jpcoar:affiliationName":[{"@value":"9M4I Division of Nanoscopy, Maastricht University, Maastricht, the Netherlands."}]},{"@id":"https://cir.nii.ac.jp/crid/1382262946333343627","@type":"Researcher","foaf:name":[{"@value":"Alexander van Oudenaarden"}],"jpcoar:affiliationName":[{"@value":"1Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, Utrecht, the Netherlands."}]},{"@id":"https://cir.nii.ac.jp/crid/1382262946333343745","@type":"Researcher","foaf:name":[{"@value":"Hans Clevers"}],"jpcoar:affiliationName":[{"@value":"1Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, Utrecht, the Netherlands."},{"@value":"5Princess Maxima Center, Utrecht, the Netherlands."}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"21598274"},{"@type":"EISSN","@value":"21598290"}],"prism:publicationName":[{"@value":"Cancer 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